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Nature Cell Biology 10, 1385–1387 (1 December 2008) | doi:10.1038/ncb1208-1385
Under arrest in mitosis: Cdc20 dies twice
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Abstract
When somatic cells enter mitosis, they reorganize their microtubule cytoskeleton to form a bipolar structure called the mitotic spindle on which duplicated chromosomes are segregated. Not surprisingly, this is a highly complex biomechanical process that is vital for the genetic integrity of dividing cells, with errors leading to aneuploidy and chromosome instability phenotypes typical of many cancers.
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