Abstract
Most, perhaps all cells in epithelial sheets are polarized in the plane of the sheet. This type of polarity, referred to as planar cell polarity (PCP), can be expressed in the orientation of cilia and stereocilia, in oriented outgrowths such as hairs, in the plane of cell division, in directed cell movement and possibly in the orientation of axon extension1,2. Another popular area in current research is growth: there is an attempt to find systems that fix the shape and size of organs. Although both polarity and growth are subject to overall control by morphogen gradients3, the mechanisms of this control are almost completely unknown. Here we discuss recent evidence for a 'steepness hypothesis' that links these two apparently disconnected features of animal development.
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References
Wang, Y. & Nathans, J. Development 134, 647–658 (2007).
Zallen, J.A. Cell 129, 1051–1063 (2007).
Zecca, M., Basler, K. & Struhl, G. Development 121, 2265–2278 (1995).
Lawrence, P.A. Adv. Insect Physiol. 7, 197–266 (1970).
Lawrence, P.A. J. Exp. Biol. 44, 607–620 (1966).
Struhl, G., Barbash, D.A. & Lawrence, P.A. Development 124, 2155–2165 (1997).
Yang, C., Axelrod, J.D. & Simon, M.A. Cell 108, 675–688 (2002).
Casal, J., Lawrence, P.A. & Struhl, G. Development 133, 4561–4572 (2006).
Day, S.J. & Lawrence, P.A. Development 127, 2977–2987 (2000).
Lawrence, P.A. Nature 429, 247 (2004).
Lawrence, P.A., Struhl, G. & Casal, J. Nature Rev. Genet. 8, 555–563 (2007).
Rogulja, D. & Irvine, K.D. Cell 123, 449–461 (2005).
Casal, J., Struhl, G. & Lawrence, P.A. Curr. Biol. 12, 1189–1198 (2002).
Reddy, B.V. & Irvine, K.D. Development 135, 2827–2838 (2008).
Bryant, P.J., Huettner, B., Held, L.I., Jr., Ryerse, J. & Szidonya, J. Dev. Biol. 129, 541–554 (1988).
Bennett, F.C. & Harvey, K.F. Curr. Biol. 16, 2101–2110 (2006).
Cho, E. et al. Nature Genet. 38, 1142–1150 (2006).
Silva, E., Tsatskis, Y., Gardano, L., Tapon, N. & McNeill, H. Curr. Biol. 16, 2081–2089 (2006).
Willecke, M. et al. Curr. Biol. 16, 2090–2100 (2006).
Hariharan, I.K. & Bilder, D. Annu. Rev. Genet. 40, 335–361 (2006).
Mahoney, P.A. et al. Cell 67, 853–868 (1991).
Ishikawa, H.O., Takeuchi, H., Haltiwanger, R.S. & Irvine, K.D. Science 321, 401–404 (2008).
Ma, D., Yang, C.H., McNeill, H., Simon, M.A. & Axelrod, J.D. Nature (2003).
Strutt, H. & Strutt, D. Dev Cell 3, 851–863 (2002).
Rogulja, D., Rauskolb, C. & Irvine, K.D. Dev. Cell 15, 309–321 (2008).
Willecke, M., Hamaratoglu, F., Sansores-Garcia, L., Tao, C. & Halder, G. Proc. Natl Acad. Sci. USA 195, 14897–14902 (2008).
Strutt, H., Mundy, J., Hofstra, K. & Strutt, D. Development 131, 881–890 (2004).
Zeidler, M.P., Perrimon, N. & Strutt, D.I. Dev. Biol. 228, 181–196. (2000).
Mao, Y. et al. Development 133, 2539–2551 (2006).
Matakatsu, H. & Blair, S.S. Development (2006).
Simon, M.A. Development 131, 6175–6184 (2004).
Zecca, M. & Struhl, G. Development 134, 3001–3010 (2007).
Zecca, M. & Struhl, G. Development 134, 3011–3020 (2007).
Lawrence, P.A., Crick, F.H.C. & Munro, M. J. Cell Sci. 11, 815–853 (1972).
Saucedo, L.J. & Edgar, B.A. Nature Rev. Mol. Cell Biol. 8, 613–621 (2007).
Thompson, D. W. Growth and Form (Cambridge University Press, 1917).
Huxley, J. S. Problems of Relative Growth (Methuen, London, 1932).
Acknowledgements
We thank the Wellcome Trust and the Medical Research Council, UK for support. G.S. is a Howard Hughes Medical Institute Investigator.
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Lawrence, P., Struhl, G. & Casal, J. Do the protocadherins Fat and Dachsous link up to determine both planar cell polarity and the dimensions of organs?. Nat Cell Biol 10, 1379–1382 (2008). https://doi.org/10.1038/ncb1208-1379
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DOI: https://doi.org/10.1038/ncb1208-1379
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