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Nature Cell Biology 10, 16–18 (1 January 2008) | doi:10.1038/ncb0108-16

Getting invasive with GEP100 and Arf6

Ferran Valderrama & Anne J. Ridley

Tumours become malignant when cancer cells migrate into neighbouring tissues and survive at these ectopic sites. Invasion and metastasis are the hallmarks of cancer malignancy, although invasion is not unique to cancer: cells invade tissues during embryonic development, in immune surveillance and in non-cancerous diseases.