Article abstract
Focus on Membrane Traffic abstract
Nature Cell Biology 1, 362 - 368 (1999)
Published online: 16 September 1999 | doi:10.1038/14058
Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells
Ana Rodriguez1, Armelle Regnault1, Monique Kleijmeer2, Paola Ricciardi-Castagnoli3 & Sebastian Amigorena1
Abstract
In order for cytotoxic T cells to initiate immune responses, peptides derived from internalized antigens must be presented to the cytotoxic T cells on major histocompatibility complex (MHC) class I molecules. Here we show that dendritic cells, the only antigen-presenting cells that initiate immune responses efficiently, have developed a unique membrane transport pathway linking the lumen of endocytic compartments and the cytosol. Endosome-to-cytosol transport is restricted to dendritic cells, specific to internalized antigens and selective for the size of the transported molecules. Thus, in dendritic cells, internalized antigens gain access to the cytosolic antigen-processing machinery and to the conventional MHC class I antigen-presentation pathway.
-
Institut National de la Santé et de la Recherche
Médicale U520, Institut Curie, Section de Recherche,
75005 Paris, France
e-mail: sebastian.amigorena@curie.fr - Department of Cell Biology, UMC, Institute of Biomembranes , 3584 CX Utrecht, The Netherlands
- University of Milano-Bicocca, Department of Biotechnology and Bioscience, via L. Emmanuli 12 bis, 20126 Milan, Italy
