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Ma et al. show that exposure of Caenorhabditis elegans to mitochondrial stress triggers stress adaptation in offspring, which is mediated by 6mA DNA modification at mitochondrial unfolded-protein-response genes.
Xin et al. track stem cells in live mice to show that fate determination is a flexible process during homeostatic hair follicle growth, and progenitor cells can change differentiation outcomes as a consequence of dynamic relocation.
di Ronza et al. identify CLN8 as a cargo receptor for lysosomal enzymes required for their endoplasmic-reticulum-to-Golgi transport, linking Batten disease caused by CLN8 mutations to defects in organelle biogenesis.
Opposing kinesin-2 and dynein-1b motors drive IFT bidirectionally along microtubules. Using cryo-electron tomography, Jordan et al. uncover mechanisms of dynein-1 inhibition to promote unidirectional IFT to the ciliary tip.
Using super-resolution microscopy, tracking of single particle trajectories of endoplasmic reticulum (ER) luminal proteins traversing tubular ER, and measuring ER dynamics, Holcman et al. show that ER content is propelled by active luminal flow.
Studying early Drosophila wing epithelium development, Singh et al. find that individual cells are mechanically autonomous, and that their elongation along the proximal–distal axis is driven by polarized microtubule-mediated pushing forces.
Chan Wah Hak et al. show how plasma membrane patches are primed for fast endophilin-mediated endocytosis and disassembly, in the absence of receptor stimulation, through FBP17 and CIP4 binding to SHIP2 and lamellipodin.
Beumer et al. show that intestinal enteroendocrine cells adjust their hormonal profile during migration from the crypt to the villus, depending on region-specific BMP signalling.
Using a heterokaryon system, Mai et al. demonstrate that NKX3-1 is downstream of IL-6–STAT3, regulates endogenous OCT4 expression during human iPSC reprogramming, and can also substitute for exogenous OCT4 in the reprogramming cocktail.
Garcia-Bermudez et al. and Sullivan et al. show that endogenous aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours, and that metformin depletes aspartate to limit tumour growth.
Garcia-Bermudez et al. and Sullivan et al. show that endogenous aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours, and that metformin depletes aspartate to limit tumour growth.
Monitoring growing epithelial cells through the cell cycle, Uroz et al. find that cell–cell tension and cell–matrix traction forces differ across the cell cycle and affect cell cycle duration, the G1–S transition and mitotic rounding.
Zhang et al. report that tRNA methyltransferase Dnmt2 is required for sperm small-non-coding-RNA-mediated transmission of paternal metabolic disorders to the offspring.
Using super-resolution microscopy and cryo-electron microscopy, Stoldt et al. show that mitochondrial transcript translation and OXPHOS complex assembly are spatially partitioned within the mitochondrial membrane.
Ghose et al. show that EFF-1 fusogen generates a sealed phagosome during engulfment of cells with long processes in Caenorhabditis elegans, and different mechanisms are required for soma, distal and proximal process clearance.
Floros et al. show that mtDNA copy number is reduced and non-synonymous mtDNA mutations are eliminated to prevent mtDNA mutation accumulation in germ cells during human primordial germ cell development.
Ibarra-Soria et al. study cellular diversity, transcriptional signatures, lineage specification and somitogenesis on a single-cell level in E8.25 mouse embryos, and reveal the regulation of blood progenitor formation by the leukotriene pathway.