Volume 33 Issue 10, October 2015

Editorial

Standing up for science

Smear campaigns against those speaking out against scaremongering on genetically modified (GM) crops highlight why support for scientists involved in public outreach is so important.

Editorial 08 Oct 2015

Advertisement
No sample left behind

Maximizing the clinical impact of immune profiling will require dedicated immune monitoring facilities and community standards for handling patient samples.

Editorial 08 Oct 2015

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News

Ebola vaccine trial falls short of homerun

Laura DeFrancesco
News 08 Oct 2015
Roche gobbles Smarticles

News 08 Oct 2015
Illumina opens Helix genomics store

News 08 Oct 2015
First US biosimilar launch

News 08 Oct 2015
GSK collaborates with Apple on ResearchKit

Michael Eisenstein
News 08 Oct 2015
First 3D-printed pill

News 08 Oct 2015
Syngenta rebuffs Monsanto, again

News 08 Oct 2015
Cat poop coffee goes biotech

News 08 Oct 2015
Landmark green light for Mosquirix malaria vaccine

Chris Morrison
News 08 Oct 2015
Around the world in a month

News 08 Oct 2015
Kirk, to boldly go into synthetic biology

Emily Waltz
News 08 Oct 2015

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News Feature

Gene drive overdrive

The recent publication of a simple procedure for creating a CRISPR-Cas9-mediated gene drive has some researchers sounding the alarm. What are the risks to populations in the wild and what precautions are necessary? Laura DeFrancesco investigates.

News Feature 08 Oct 2015

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Bioentrepreneur

Philanthropy's role in translating scientific innovation

How can nonprofit funders help launch your biotech startup?

Hemai Parthasarathy
Lindy Fishburne
Bioentrepreneur 08 Oct 2015

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Correspondence

Lessons in simplicity that should shape the future of drug delivery

Koen Raemdonck
Stefaan C De Smedt
Correspondence 08 Oct 2015
Professionalism and ethics in animal research

Nikola Biller-Andorno
Herwig Grimm
Rebecca L Walker
Correspondence 08 Oct 2015
Chinese government reaffirms backing for GM products

Rongrong Li
Qiang Wang
Alan McHughen
Correspondence 08 Oct 2015
Increased bioavailable vitamin B₆ in field-grown transgenic cassava for dietary sufficiency

Kuan-Te Li
Michael Moulin
Hervé Vanderschuren
Correspondence 08 Oct 2015

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Patents

Gene patent practice across plant and human genomes

The uses of genetic sequences to inform, enable or create products or services for human biomedicine are substantially different from their uses in crop-based agriculture.

Osmat A Jefferson
Deniz Köllhofer
Richard A Jefferson
Patents 08 Oct 2015
Recent patents in synthetic nucleic acids and proteins

Patents 08 Oct 2015

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News & Views

A BiTE from cancer's intracellular menu

T cells are targeted to tumor cells expressing an intracellular antigen using a bispecific antibody.

Alexander I Salter
Stanley R Riddell
News & Views 08 Oct 2015
Strain recovery from metagenomes

Genome assembly of closely related strains present in very large metagenome data sets is enabled by a de novo pre-assembly algorithm.

C Titus Brown
News & Views 08 Oct 2015
Stabilizing prospects for a universal flu vaccine

News & Views 08 Oct 2015
Research Highlights

News & Views 08 Oct 2015

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Analysis

ConStrains identifies microbial strains in metagenomic datasets

Different bacterial strains in a metagenome are distinguished using a method that detects SNPs in conserved genes.

Chengwei Luo
Rob Knight
Dirk Gevers
Analysis 07 Sept 2015
Detection of low-abundance bacterial strains in metagenomic datasets by eigengenome partitioning

Bacterial strains that make up as little as 0.00001% of a microbial community are detected in metagenomic sequencing data.

Brian Cleary
Ilana Lauren Brito
Eric J Alm
Analysis 14 Sept 2015

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Perspective

Systems strategies for developing industrial microbial strains

Ten general strategies for the development of industrial microbial strains, together with selected case studies, are discussed.

Sang Yup Lee
Hyun Uk Kim
Perspective 08 Oct 2015

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Brief Communication

Subangstrom single-molecule measurements of motor proteins using a nanopore

The movement of single motor proteins on DNA is measured at subangstrom resolution using a nanopore.

Ian M Derrington
Jonathan M Craig
Jens H Gundlach
Brief Communication 28 Sept 2015
Improving folate (vitamin B₉) stability in biofortified rice through metabolic engineering

Folate stability in stored biofortified rice is improved by complexing to folate-binding proteins.

Dieter Blancquaert
Jeroen Van Daele
Dominique Van Der Straeten
Brief Communication 21 Sept 2015

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Article

Therapeutic bispecific T-cell engager antibody targeting the intracellular oncoprotein WT1

A bi-specific antibody that binds both T cells and a tumor-specific intracellular antigen shows therapeutic promise in mouse models of cancer.

Tao Dao
Dmitry Pankov
David A Scheinberg
Article 21 Sept 2015

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Letter

De novo sequencing and variant calling with nanopores using PoreSeq

Nanopore sequencing of microbial genomes is achieved at low coverage without a reference genome using PoreSeq.

Tamas Szalay
Jene A Golovchenko
Letter 09 Sept 2015
Optogenetic control of endogenous Ca²⁺ channels in vivo

A single-component optogenetic tool controls calcium fluxes with high dynamic range.

Taeyoon Kyung
Sangkyu Lee
Won Do Heo
Letter 14 Sept 2015
Engineering pulmonary vasculature in decellularized rat and human lungs

In a step toward bioengineered lungs, the vasculature is regenerated in decellularized rat and human lung scaffolds.

Xi Ren
Philipp T Moser
Harald C Ott
Letter 14 Sept 2015

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Resource

A catalog of the mouse gut metagenome

The mouse gut microbiome is catalogued and compared to the human microbiome.

Liang Xiao
Qiang Feng
Karsten Kristiansen
Resource 28 Sept 2015

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Erratum

Erratum: Prediction of human population responses to toxic compounds by a collaborative competition

Federica Eduati
Lara M Mangravite
Julio Saez-Rodriguez
Erratum 08 Oct 2015
Erratum: Drug pipeline: 2Q15

Laura DeFrancesco
Erratum 08 Oct 2015

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Corrigendum

Correction: Corrigendum: Assembling large genomes with single-molecule sequencing and locality-sensitive hashing

Konstantin Berlin
Sergey Koren
Adam M Phillippy
Corrigendum 08 Oct 2015

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Careers and Recruitment

The right track for you in biotech and biomedical sciences

In Singapore, a recent panel showcased the many career paths and options available for those in the biotech sector.

Laxmi Ravi Iyer
Sandhya Sriram
Careers and Recruitment 08 Oct 2015
People

Careers and Recruitment 08 Oct 2015

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Volume 33 Issue 10, October 2015

Editorial

News

News Feature

Bioentrepreneur

Correspondence

Patents

News & Views

Analysis

Perspective

Brief Communication

Article

Letter

Resource

Erratum

Corrigendum

Careers and Recruitment

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