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  • Review Article
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Atrial Natriuretic Peptide

Bio/Technology volume 6, pages 529–546 (1988)Cite this article

Abstract

Atrial natriuretic peptide (ANP) stimulates vasodilation, fluid egress, increased glomerular filtration and salt and water excretion, and blocks the release and/or actions of several hormones, including angiotensin II, aldosterone and vasopressin. ANP levels are commonly elevated in situations of excessive fluid volume or hypertension, and the hormone may be important in combatting these states. ANP is derived from a precursor protein produced by the cardiac atrium and at lower levels by other tissues. Two classes of ANP receptors present in vascular, renal and other tissues are linked respectively, to either guanylate cyclase and possibly other second messengers, or to ANP clearance. ANP shows promise as an agent to treat heart failure, renal failure and fluid excess states.

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References

  1. Metzler, C.H., Gardner, D.G., Keil, L.C., Baxter, J.D. and Ramsay, D.J. 1987. Increased synthesis and release of atrial peptide during mineralocorticoid escape in conscious dogs. Am J. Physiol. 252:R188–R192.

    CAS  PubMed  Google Scholar 

  2. Zimmerman, R.S., Edwards, B.S., Schwab, T.R., Heublein, D.M. and Burnett, J.C., Jr. 1987. Atrial natriuretic peptide during mineralocorticoid escape in the human. J. Clin. Endocrin. Metab. 64:624–627.

    CAS  Google Scholar 

  3. Knox, F.G., Burnett, J.C., Kohan, D.E., Spielman, W.S., Strand, J.C. 1980. Escape from the sodium retaining effects of mineralocorticoid. Kid. Int. 17:263–276.

    CAS  Google Scholar 

  4. Baxter, J.D., Perloff, D., Hsueh, W., Biglieri, E.G. 1987. The endocrinology of hypertension, p. 693–788. In: Endocrinology and Metabolism. P. Felig, J. D. Baxter, A. E. Broadus, L. A. Frohman (Eds.). McGraw Hill, New York.

    Google Scholar 

  5. Haddy, F.J. 1987. Endogenous digitalis-like factor or factors. N. Eng. J. Med. 316:621–623.

    CAS  Google Scholar 

  6. Kisch, B. 1956. Electron microscopy of the atrium of the heart. I. Guinea pig. Exp. Med. Surg. 14:99–112.

    CAS  PubMed  Google Scholar 

  7. deBold, A.J. 1979. Heart atrial granularity. Effects of changes in water and electrolyte balance. Proc. Soc. Exp. Biol. Med. 161:508–511.

    CAS  Google Scholar 

  8. Marie, J.-P., Guillemot, H. and Hatt, P.Y. 1976. Le degré de granulation des cardiocytes auriculaires: Étude planimetrique au cours de differents apports de'eau et de sodium chez le rat. Pathol. Biol. 24:549–554.

    CAS  PubMed  Google Scholar 

  9. deBold, A.J. 1982. Tissue fractionation studies on the relationship between an atrial natriuretic factor and specific atrial granules. Can. J. Physiol. Pharmacol. 60:324–330.

    CAS  Google Scholar 

  10. Atlas, S.A., Kleinert, H.D., Camargo, M.J., Januszewicz, A., Sealey, J.E., Laragh, J.H., Schilling, J.W., Lewicki, J.A., Johnson, L.K. and Maack, T. 1984. Purification, sequencing and synthesis of natriuretic and vasoactive rat atrial peptide. Nature 309:717–719.

    CAS  PubMed  Google Scholar 

  11. Seidah, N.G., Lazure, C., Chretien, M., Thibault, G., Garcia, R., Cantin, M., Genest, J., Nutt, R.F., Brady, S.F., Lyle, T.A., Palereda, W.S., Colton, C.D., Ciccarone, T.M. and Veber, D.F. 1984. Amino acid sequence of homologous rat atrial peptides: Natriuretic activity of native and synthetic forms. Proc. Natl. Acad. Sci. USA 81:2640–2644.

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Currie, M.G., Geller, D.M., Cole, B.R., Siegel, N.R., Fok, K.F., Adams, S.P., Eubanks, S.R., Galluppi, G.R. and Needleman, P. 1983. Purification and sequence analysis of bioactive atrial peptides (atriopeptins). Science 21:67–69.

    Google Scholar 

  13. Maki, M., Takayanagi, R., Misono, K.S., Pandey, K.N., Tibbetts, C. and Inagami, T. 1984. Structure of rat ANF precursor deduced from cDNA sequence. Nature 309:722–724.

    CAS  PubMed  Google Scholar 

  14. Seidman, C., Duby, A., Choi, E., Graham, R., Haber, E., Homcy, C., Smith, J. and Seidman, J. 1984. Structure of rat pre-proatrial natriuretic factor as defined by a complementary DNA clone. Science 225:324–326.

    CAS  PubMed  Google Scholar 

  15. Yamanaka, M., Greenberg, B., Johnson, L., Seilhamer, J., Brewer, M., Friedemann, T., Miller, J., Atlas, S., Laragh, J., Lewicki, J. and Fiddes, J. 1984. Cloning and sequence analysis of the cDNA for the rat ANF precursor. Nature 309:719–722.

    PubMed  Google Scholar 

  16. Zivin, R., Condra, J., Dixon, R., Seidah, N., Chretien, M., Nemer, M., Chamberland, M. and Drouin, J. 1984. Molecular cloning and characterization of DNA sequences encoding rat and human ANF. Proc. Natl. Acad. Sci. USA 81:6325–6329.

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Nakayma, K., Ohkubo, H., Hirose, T., Inayama, S. and Nakanishi, S. 1984. mRNA sequence for human cardiodilatin-atrial natriuretic factor precursor and regulation of precursor mRNA in rat atria. Nature 310:699–701.

    Google Scholar 

  18. Oikawa, S., Imai, M., Ueno, A., Tanaka, S., Noguchi, T., Nakazato, H., Kangawa, K., Fukuda, A. and Matsuo, H. 1984. Cloning and sequence analysis of cDNA encoding a precursor for human ANP. Nature 309:724–726.

    CAS  PubMed  Google Scholar 

  19. Oikawa, S., Imai, M., Inuzuka, C., Tawaragi, Y., Nakazato, H. and Matsuo, H. 1985. Structure of dog and rabbit precursors of atrial natriuretic polypeptides deduced from nucleotide sequence of cloned cDNA. Biochem. Biophys. Res. Commun. 132:892–899.

    CAS  PubMed  Google Scholar 

  20. Nakao, K., Itoh, H., Mukoyama, M., Morii, N., Sugawara, A., Yamada, T., Shiono, S., Saito, Y., Arai, H. and Imura, H. 1987. N-Terminal fragment of γ-human atrial natriuretic polypeptide (γ)-human ANP) is present in atrium and co-secreted with α-human ANP into circulation in man. Proceedings of the 2nd World Congress on Biol. Active Peptides. Abst. B9, p. 202.

  21. Forssman, W.G., Hock, D., Lottspeich, F., Henscher, A., Kreyl, V., Christmann, M., Reinecke, M., Metz, J., Carliquist, M. and Mutt, V. 1983. The right auricle of the heart is an endocrine organ. Anat. Embryol. 168:307–313.

    Google Scholar 

  22. Greenberg, B., Bencen, G., Seilhamer, J., Lewicki, J. and Fiddes, J. 1984. Nucleotide sequence of the gene encoding human ANF precursor. Nature 312:656–658.

    CAS  PubMed  Google Scholar 

  23. Maki, M., Parmentier, M., and Inagami, T. 1984. Cloning of the genomic DNA for human ANF. Biochem. Biophys. Res. Commun. 125:797–802.

    CAS  PubMed  Google Scholar 

  24. Seidman, C., Bloch, K., Klein, K., Smith, J., and Seidman, J. 1984. Nucleotide sequences of the human and mouse atrial natriuretic factor genes. Science 226:1206–1209.

    CAS  PubMed  Google Scholar 

  25. Argentin, S., Nemer, M., Drouin, J., Scott, G., Kennedy, B., and Davies, P. 1985. The gene for rat atrial natriuretic factor. J. Biol. Chem. 260:4568–4571.

    CAS  PubMed  Google Scholar 

  26. Vlasuk, G., Miller, J., Bencen, G., and Lewicki, J. 1986. Structure and analysis of the bovine atrial natriuretic peptide precursor gene. Biochem. Biophys. Res. Commun. 136:396–403.

    CAS  PubMed  Google Scholar 

  27. Karin, M., Haslinger, A., Holtgreve, H., Richards, R.I., Krauter, P., Westphal, W.M., and Beato, M. 1984. Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein II gene. Nature 308:513–519.

    CAS  PubMed  Google Scholar 

  28. Nordeim, A., and Rich, A. 1983. Negatively supercoiled simian virus 40 DNA contains Z-DNA segments within transcriptional enhancer sequences. Nature 303:674–679.

    Google Scholar 

  29. Gardner, D.G., Deschepper, C.F., Ganong, W.F., Hane, S., Fiddes, J., Baxter, J.D., and Lewicki, J. 1986. Extra-atrial expression of the gene for atrial natriuretic factor. Proc. Natl. Acad. Sci. USA 83:6698–6701.

    Google Scholar 

  30. Gardner, D.G., Vlasuk, G.P., Baxter, J.D., Fiddes, J.C., and Lewicki, J.A. 1987. Identification of atrial natriuretic factor gene transcripts in the central nervous system of the rat. Proc. Natl. Acad. Sci. USA 84:2175–2179.

    CAS  PubMed  PubMed Central  Google Scholar 

  31. Day, M.L., Schwartz, D., Wiegand, R.C., Stockman, P.T., Brunnert, S.R., Tolunay, H.E., Currie, M.G., Standaert, D.G., and Needle-man, P. 1987. Ventricular atriopeptin: unmasking of mRNA and peptide synthesis by hypertrophy or dexamethasone. Hypertension 9:485–491.

    CAS  PubMed  Google Scholar 

  32. Lattion, A.-L., Michel, J.-B., Arnauld, E., Corvol, P., and Sombrier, F. 1986. Myocardial recruitment during ANF mRNA increase with volume overload in the rat. Am. J. Physiol. 251:H890–H896.

    CAS  PubMed  Google Scholar 

  33. Bloch, K.D., Seidman, J.G., Naftilan, J.D., Fallon, J.T., and Seidman, C.E. 1986. Neonatal atria and ventricles secrete atrial natriuretic factor via tissue-specific secretory pathways. Cell 47:695–702.

    CAS  PubMed  Google Scholar 

  34. Gardner, D.G., Deschepper, C.F., and Baxter, J.D. 1987. The gene for the atrial natriuretic factor is expressed in the aortic arch. Hypertension 9:103–106.

    CAS  PubMed  Google Scholar 

  35. Saper, C.B., Standaert, D.G., Currie, M.G., Schwartz, D., Geller, D.M., and Needleman, P. 1985. Atriopeptin-immunoreactive neurons in the brain: Presence in cardiovascular regulatory areas. Science 227:1047–1049.

    CAS  PubMed  Google Scholar 

  36. Jacobowitz, D.M., Skofitsch, G., Keiser, H.R., Eskay, R.L., and Zamir, N. 1985. Evidence for the existence of atrial natriuretic factor-containing neurons in the rat brain. Neuroendocrinology 40 92–94.

    CAS  PubMed  Google Scholar 

  37. Glembotski, C.C., Wildey, G.M., and Gibson, T.R. 1985. Molecular forms of immunoreactive atrial natriuretic peptide in the rat hypothalamus and atrium. Biochem. Biophys. Res. Commun. 129:671–678.

    CAS  PubMed  Google Scholar 

  38. Shiono, S., Nakao, K., Morii, N., Yamada, T., Itoh, H., Sakamoto, M., Sugawara, A., Saito, Y., Katsuura, G., and Imura, H. 1986. Nature of atrial natriuretic polypeptide in rat brain. Biochem. Biophys. Res. Commun. 135:728–736.

    CAS  PubMed  Google Scholar 

  39. Standaert, D.G., Needleman, P., and Saper, C.B. 1986. Organization of atriopeptin-like immunoreactive neurons in the central nervous system of the rat. J. Comp. Neuro. 253:315–341.

    CAS  Google Scholar 

  40. Debinski, W., Gutkowska, J., Kuchel, O., Racz, K., Buu, N.T., Cantin, M., and Genest, J. 1987. Presence of an atrial natriuretic factor-like peptide in the rat superior cervical ganglion. Neuroendocrinology 46:236–240.

    CAS  PubMed  Google Scholar 

  41. Debinski, W., Gutkowska, J., Kuchel, O., Racz, K., Buu, N.T., Cantin, M., and Genest, J. 1986. ANF-like peptides in the peripheral autonomic nervous system. Biochem. Biophys. Res. Commun. 134:279–284.

    CAS  PubMed  Google Scholar 

  42. McKenzie, J.C., Tanaka, I., Misono, K.S., and Inagami, T. 1985. Immunocytochemical localization of atrial natriuretic factor in the kidney, adrenal medulla, pituitary and atrium of the rat. J. of Histochem. and Cytochem. 33:828–832.

    CAS  Google Scholar 

  43. Schwartz, D., Geller, D.M., Manning, P.T., Siegel, N.R., Fok, F., Smith, C.E., and Needleman, P. 1985. Ser-Leu-Arg-Arg-Atriopeptin III: The major circulating form of atrial peptide. Science 229:397–400.

    CAS  PubMed  Google Scholar 

  44. Vuolteenaho, O., Arjamaa, O., and Ling, N. 1985. Atrial natriuretic polypeptides (ANP): rat atria store high molecular weight precursor but secrete processed peptides of 25–35 amino acids. Biochem. Biophys. Res. Commun. 129:82–88.

    CAS  PubMed  Google Scholar 

  45. Bloch, K.D., Scott, J.A., Zisfein, J.B., Fallon, J.T., Margolis, M.N., Seidman, C.E., Matsueda, G.R., Homcy, C.J., Graham, R.M., and Seidman, J.G. 1985. Biosynthesis and secretion of proatrial natriuretic factor by cultured rat cardiocytes. Science 230:1168–1171.

    CAS  PubMed  Google Scholar 

  46. Hilliker, S., Vlasuk, G., Borden, L., Hancock, N., Scarborough, R., Schwartz, L., and Lewicki, J. 1986. Fate of the atrial natriuretic peptide precursor in the circulation. Program of the 1st World Conference on Biol. Active Peptides. Abst. p. 90A.

  47. Trippodo, N.C., Januszewicz, A., Pegram, B.L., Cole, F.E., Kohashi, N., Kardon, M.B., MacPhee, A.A., and Frohlich, E.D. 1985. Rat platelets activate high molecular weight atrial natriuretic peptides in vitro. Hypertension 7:905–912.

    CAS  PubMed  Google Scholar 

  48. Bloch, K.D., Zisfein, J.B., Margolies, M.N., Homcy, C.J., Seidman, J.G., and Graham, R.M. 1987. A serum protease cleaves pro-ANF into a 14-kiloDalton peptide and ANF. Am. J. Physiol. 252:E147–E151.

    CAS  PubMed  Google Scholar 

  49. Gibson, T.R., Shields, P.P., and Glembotski, C.C. 1987. The conversion of atrial natriuretic peptide (ANP)- (1–126) to ANP- (99–126) by rat serum: contribution to ANP cleavage in isolated perfused rat hearts. Endocrinology 120:764–772.

    CAS  PubMed  Google Scholar 

  50. Imada, T., Takayanagi, R., and Inagami, T. 1987. Identification of a peptidase which processes atrial natriuretic factor precursor to its active form with 28 amino acid residues in particulate fraction of rat atrial homogenate. Biochem. Biophys. Res. Commun. 143:587–592.

    CAS  PubMed  Google Scholar 

  51. Rittenhouse, J., Moberly, L., O'Donnell, M.E., Owen, N.E., and Marcus, F. 1986. Phosphorylation of atrial natriuretic peptides by cyclic AMP-dependent protein kinase. J. Biol. Chem. 261:7607–7610.

    CAS  PubMed  Google Scholar 

  52. Bloch, K.D., Jones, S.W., Preibisch, G., Seipke, G., Seidman, C.E., and Seidman, J.G. 1987. Proatrial natriuretic factor is phosphorylated by rat cardiocytes in culture. J. Biol. Chem. 262:9956–9961.

    CAS  PubMed  Google Scholar 

  53. Lang, R.E., Tholken, H., Ganten, D., Luft, F.C., Ruskoaho, H., and Unger, Th. 1985. Atrial natriuretic factor-a circulating hormone stimulated by volume loading. Nature 314:264–266.

    CAS  PubMed  Google Scholar 

  54. Ballerman, B.J., Bloch, K.D., Seidman, J.G., and Brenner, B.M. 1986. Atrial natriuretic peptide transcription, secretion and giomerular receptor activity during mineralocorticoid escape in the rat. J. Clin. Invest. 78:840–843.

    Google Scholar 

  55. Garcia, R., Debinski, W., Gutkowska, J., Kuchel, O., Thibault, G., Genest, J., and Cantin, M. 1985. Gluco- and mineralocorticoids may regulate the natriuretic effect and the synthesis and release of atrial natriuretic factor by the rat atria in vivo. Biochem. Biophys. Res. Commun. 131:806–814.

    CAS  PubMed  Google Scholar 

  56. Ding, J., Thibault, G., Gutkowska, J., Garcia, R., Karabatsos, T., Gaetan, J., Genest, J., and Cantin, M. 1987. Cardiac and plasma atrial natriuretic factor in experimental congestive heart failure. Endocrinology 12:248–257.

    Google Scholar 

  57. Cody, R.J., Atlas, S.A., Laragh, J.H., Kubo, S.H., Covit, A.B., Ryman, K.S., Shakanovich, A., Pondolfino, K., Clark, M., Camargo, M.J.F., Scarborough, R.M., and Lewicki, J.A. 1986. Atrial natriuretic factor in normal subjects and heart failure patients. J. Clin. Invest. 78:1362–1374.

    CAS  PubMed  PubMed Central  Google Scholar 

  58. Imada, T., Takayanagi, R., and Inagami, T. 1985. Changes in the content of atrial natriuretic factor with the progression of hypertension in spontaneously hypertensive rats. Biochem. Biophys. Res. Commun. 133:759–765.

    CAS  PubMed  Google Scholar 

  59. Snajdar, R.M., and Rapp, J.P. 1986. Elevated atrial natriuretic polypeptide in plasma of hypertensive Dahl salt-sensitive rats. Biochem. Biophys. Res. Commun. 137:876–883.

    CAS  PubMed  Google Scholar 

  60. Manning, P.T., Schwartz, D., Katsube, N.C., Holmberg, S.W., and Needleman, P. 1985. Vasopressin-stimulated release of atriopeptin: Endocrine antagonists in fluid homeostasis. Science 229:395–397.

    CAS  PubMed  Google Scholar 

  61. Metzler, C.H., Lee, M.-E., Thrasher, T.N., and Ramsay, D.J. 1986. Increased right or left atrial pressure stimulates release of atrial natriuretic peptides in conscious dogs. Endocrinology 119:2396–2398.

    CAS  PubMed  Google Scholar 

  62. Gardner, D.G., Hane, S., Trachewsky, D., Schenk, D., and Baxter, J.D. 1986. Atrial natriuretic peptide mRNA is regulated by glucocorticoids in vivo. Biochem. Biophys. Res. Commun. 139:1047–1054.

    CAS  PubMed  Google Scholar 

  63. Gardner, D.G., Gertz, B.J., and Hane, S. 1987. Thyroid hormone increases ANP mRNA accumulation in vivo, and in vitro. Molec. Endocrinology 1:260–265.

    CAS  Google Scholar 

  64. Kohno, M., Takaori, K., Matsuura, T., Murakewa, K., Kanayama, Y., and Takeda, T. 1986. Atrial natriuretic polypeptide in atria and plasma in experimental hyperthyroidism and hypothyroidism. Biochem. Biophys. Res. Commun. 134:178–183.

    CAS  PubMed  Google Scholar 

  65. Dietz, J.R. 1984. Release of atrial natriuretic factor from rat heart-lung preparation by atrial distension. Am. J. Physiol. 247:R1093–R1096.

    CAS  PubMed  Google Scholar 

  66. Schiebinger, R.J., Baker, M.Z., and Linden, J. 1987. Effect of adrenergic and muscarinic cholinergic agonists on atrial natriuretic peptide secretion by isolated rat atria. J. Clin. Invest. 80:1687–1691.

    CAS  PubMed  PubMed Central  Google Scholar 

  67. Schiebinger, R.J. and Linden, J. 1986. The influence of resting tension on immunoreactive atrial natriuretic peptide secretion by rat atria superfused in vitro. Circ. Res. 59:105–109.

    CAS  PubMed  Google Scholar 

  68. Schiebinger, R.J. and Linden, J. 1986. Effect of atrial contraction frequency on atrial natriuretic peptide secretion. Am. J. Physiol. 251:H1095–H1099.

    CAS  PubMed  Google Scholar 

  69. Ruskoaho, H., Toth, M., and Lang, R.E. 1985. Atrial natriuretic peptide secretion: Synergistic effect of phorbol ester and A23187. Biochem. Biophys. Res. Commun. 133:581–588.

    CAS  PubMed  Google Scholar 

  70. Sonnenberg, H. and Veress, A.T. 1984. Cellular mechanism of release of atrial natriuretic factor. Biochem. Biophys. Res. Commun. 124:443–449.

    CAS  PubMed  Google Scholar 

  71. Takayanagi, R., Taneka, I., Maki, M., and Inagami, I. 1985. Effects of changes in water-sodium balance on levels of atrial natriuretic factor messenger RNA and peptide in rats. Life Sci. 36:1843–1848.

    CAS  PubMed  Google Scholar 

  72. Gardner, D.G., LaPointe, M.C., Wu, J., Baxter, J.D., and Gertz, B.J. 1988. Hormonal regulation of the gene for atrial natriuretic factor in press. In: Advances in Atrial Peptide Research, Vol. II. John H. Laragh and Barry M. Brenner (Eds.). Raven Press: New York.

    Google Scholar 

  73. Grekin, R.J., Ling, W.D., Shenker, Y., and Bohr, D.F. 1986. Immunoreactive atrial natriuretic hormone levels increase in deoxy-corticosterone acetate-treated pigs. Hypertension 8:II16–II20.

    CAS  PubMed  Google Scholar 

  74. Needleman, P. and Greenwald, J.E. 1986. Atriopeptin: A cardiac hormone intimately involved in fluid, electrolyte and blood-pressure homeostasis. N. Engl. J. Med. 314:828–834.

    CAS  PubMed  Google Scholar 

  75. deBold, A.J. 1985. Atrial natriuretic factor: A hormone produced by the heart. Science 230:767–769.

    CAS  Google Scholar 

  76. Maack, T., Suzuki, M., Almeida, F.A., Nussenzveig, D., Scarborough, R.M., McEnroe, G.A., and Lewicki, J.A. 1987. Physiological role of silent receptors of atrial natriuretic factor. Science 238:675–678.

    CAS  PubMed  Google Scholar 

  77. Ballermann, B.J. and Brenner, B.M. 1985. Biologically active atrial peptides. J. Clin. Invest. 76:2041–2048.

    CAS  Google Scholar 

  78. Yamaji, T., Ishibashi, M., and Takaku, F. 1985. Atrial natriuretic factor in human blood. J. Clin. Invest. 76:1705–1709.

    CAS  PubMed  PubMed Central  Google Scholar 

  79. Burnett, J.C., Jr., Kao, P.C., Hu, D.C., Heser, D.W., Heublein, D., Granger, J.P., Opgenorth, T.J., and Reeder, G.S. 1986. Atrial natriuretic peptide elevation in congestive heart failure in the human. Science 231:1145–1147.

    PubMed  Google Scholar 

  80. Atlas, S.A. 1986. Atrial natriuretic factor: A new hormone of cardiac origin. Rec. Prog. Hormone Res. 42:207–242.

    CAS  Google Scholar 

  81. Rascher, W., Tulassay, T., and Lang, R.E. 1985. Atrial natriuretic peptide in plasma of volume-overloaded children with chronic renal failure. Lancet 2:303–305.

    CAS  PubMed  Google Scholar 

  82. Weidmann, P., Hasler, L., Gnadinger, M.P., Lang, R.E., Uehlinger, D.E., Shaw, S., Rascher, W., and Reubi, F.C. 1986. Blood levels and renal effects of atrial natriuretic peptide in normal man. J. Clin. Invest. 77:734–742.

    CAS  PubMed  PubMed Central  Google Scholar 

  83. Adams, S.P. 1987. Structure and biologic properties of the atrial natriuretic peptides, p. 1–17. In: Endocrinology and Metabolism Clinics of North America: Atrial Natriuretic Factor. M. Rosenblatt and J. W. Jacobs (Eds). W. B. Saunders Co.

    Google Scholar 

  84. Atlas, S.A. and Maack, T. 1987. Effects of atrial natriuretic factor on the kidney and the rennin-angiotensin-aldosterone system, p. 107–143. Ibid.

  85. Leitman, D.C. and Murad, F. 1987. Atrial natriuretic factor receptor heterogeneity and stimulation of particulate guanylate cyclase and cyclic GMP accumulation, p. 79–105. Ibid.

  86. Winquist, R.J. 1987. Pharmacologic effects of atrial natriuretic peptide, p. 163–182. Ibid.

  87. Cogan, M.G. 1986. Atrial natriuretic factor can increase renal solute excretion primarily by raising glomerular filtration. Am. J. Physiol. 250:F710–F714.

    CAS  PubMed  Google Scholar 

  88. Huang, C.L., Lewicki, J., Johnson, L.K., and Cogan, M.G. 1985. Renal mechanism of action of rat atrial natriuretic factor. J. Clin. Invest. 75:769–773.

    CAS  PubMed  PubMed Central  Google Scholar 

  89. Samson, W.K. 1985. Atrial natriuretic factor inhibits dehydration-and hemorrhage-induced vasopressin release. Neuroendocrinology 20:227–279.

    Google Scholar 

  90. Zeidel, M.L., Seifter, J.L., Lear, S., Brenner, B.M., and Silva, P. 1986. Atrial peptides inhibit oxygen consumption in kidney medullary collecting duct cells. Am. J. Physiol. 251:F379–F383.

    CAS  PubMed  Google Scholar 

  91. Cuneo, R.C., Espiner, E.A., Nicholls, M.G., Yandle, T.G., and Livesey, J.H. 1987. Effect of physiological levels of atrial natriuretic peptide on hormone secretion: inhibition of angiotensin-induced aldosterone secretion and renin release in normal man. J. Clin. Endocrin. Metab. 65:765–772.

    CAS  Google Scholar 

  92. Tikkanen, I., Metsarinne, K., Fyhrquist, F., Leidenius, R. 1985. Plasma atrial natriuretic peptide in cardiac disease and during infusion in healthy volunteers. Lancet ii:66–69.

    Google Scholar 

  93. Biollaz, J., Nussberger, J., Porchet, M., Brunner-Feber, F., Otterbein, E.S., Gomez, H., Waeber, B., and Brunner, H.R. 1986. Four-hour infusions of synthetic atrial natriuretic peptide in normal volunteers. Hypertension 8:II96–II105.

    CAS  PubMed  Google Scholar 

  94. Saito, Y., Nakao, K., Nishimura, K., Sugawara, A., Okumura, K., Obata, K., Sonoda, R., Ban, T., Yasue, H., and Imura, H. 1987. Clinical application of atrial natriuretic polypeptide in patients with congestive heart failure: beneficial effects on left ventricular function. Circulation 76:115–124.

    CAS  PubMed  Google Scholar 

  95. Xu, C., Jiang, B., Wang, J., Sun, N., Chen, H., Liu, X., Tian, Y., Chen, S., Li, D., Xie, C., and Tang, J. 1986. Hemodynamic and renal effects of human alpha atrial natriuretic peptide in two patients with congestive heart failure. Chinese Med. J. 99:1.

    CAS  Google Scholar 

  96. Huxley, V.H., Tucker, V.L., Verburg, K.M., and Freeman, R.H. 1986. Increased capillary hydraulic conductivity induced by atrial natriuretic peptide. Circ. Res. 60:304–307.

    Google Scholar 

  97. Samson, W.K. 1987. Atrial natriuretic factor and the central nervous system, p. 145–161. In: Endocrinology and Metabolism Clinics of North America: Atrial Natriuretic Factor. Op. cit.

    Google Scholar 

  98. Nicholls, M.G. and Richards, A.M. Human studies with atrial natriuretic factor, p. 199–223. Ibid.

  99. Debinski, W., Kuchel, O., Buu, N.T., Cantin, M., and Genest, J. 1987. Atrial natriuretic factor partially inhibits the stimulated catecholamine synthesis in superior cervical ganglia of the rat. Neuroscience Letters 17:92–99.

    Google Scholar 

  100. Standaert, D.G., Cechette, D.F., Needleman, P., and Saper, C.B. 1987. Inhibition of the firing of vasopressin neurons by atriopeptin. Nature 329:151–153.

    CAS  PubMed  Google Scholar 

  101. Antunes-Rodriguez, J., McCann, S.M., and Samson, W.K. 1986. Central administration of atrial natriuretic factor inhibits saline preference in the rat. Endocrinology 118:1726–1728.

    Google Scholar 

  102. Antunes-Rodriguez, J., McCann, S.M., Rogers, L.C., and Samson, W.K. 1985. Atrial natriuretic factor inhibits dehydration and angiotensin II induced water intake in the conscious unrestrained rat. Proc. Natl. Acad. Sci. USA 82:8720–8723.

    Google Scholar 

  103. DeLean, A., Gutowska, J., McNicoll, N., Schiller, P.W., Cantin, M., Genest, J. 1984. Characteristics of specific receptors for atrial natriuretic factor in bovine adrenal zona glomerulosa. Life Sci. 35:2311–2318.

    CAS  Google Scholar 

  104. Inui, K., Saito, H., Matsukawa, Y., Nakao, K., Morii, N., Imura, H., Shimokura, M., Kiso, Y., and Hori, R. 1985. Specific binding activities and cyclic GMP responses by atrial natriuretic polypeptide in kidney epithelial cell line (LLC-PK1). Biochem. Biophys. Res. Commun. 132:253–260.

    CAS  PubMed  Google Scholar 

  105. Napier, M.S., Vandlen, R.L., Albers-Schonberg, G., Mutt, R.F., Brady, S., Lyle, T., Winquist, R., Faison, E.P., Heinel, L.A., and Blaine, E. II. 1984. Specific receptors for atrial natriuretic factor in renal and vascular tissues. Proc. Natl. Acad. Sci. USA 81:5946–5950.

    CAS  PubMed  PubMed Central  Google Scholar 

  106. Shenk, D.B., Johnson, K.K., Schwartz, K., Sista, H., Scarborough, R.M., and Lewicki, J.A. 1985. Distinct atrial natriuretic factor receptor sites on cultured bovine aortic smooth muscle and endothelial cells. Biochem. Biophys. Res. Commun. 127:433–442.

    Google Scholar 

  107. Bianchi, C., Gutkowska, J., Thibault, G., Garcia, R., Genest, J., and Cantin, M. 1985. Radioautographic localization of 125I-atrial natriuretic factor (ANF) in rat adrenal and kidney. Histochemistry 82:441–452.

    CAS  PubMed  Google Scholar 

  108. Scarborough, R.M., Schenk, D.B., McEnroe, G.A., Arfsten, A., Kang, L.-L., Schwartz, K., and Lewicki, J.A. 1986. Truncated atrial natriuretic peptide (ANP) analogs: Comparison between receptor binding affinity and cyclic GMP stimulation in cultured aortic smooth muscle cells. J. Biol. Chem. 261:12960–12964.

    CAS  PubMed  Google Scholar 

  109. Leitman, D.C. and Murad, F. 1986. Comparison of binding and cyclic GMP accumulation by atrial natriuretic peptides in endothelial cells. Biochim. Biophys. Acta. 885 74–79.

    CAS  PubMed  Google Scholar 

  110. Takayanagi, R., Snajdar, R.M., Imada, T., Tamura, M., Pandey, K.N., Misono, K.S., and Inagami, T. 1987. Purification and characterization of two types of atrial natriuretic factor receptors from bovine adrenal cortex: Guanylate cyclase-linked and cyclase-free receptors. Biochem. Biophys. Res. Commun. 144:244–250.

    CAS  PubMed  Google Scholar 

  111. Waldman, S.A., Rapoport, R.M., and Murad, F. 1986. Cyclic Guanosine Monophosphate as a mediator of vasodilation. J. Clin. Invest. 78:1–5.

    Google Scholar 

  112. Scarborough, R., McEnroe, G., Kang, L.L., Arfsten, A., Schwartz, Almeida, F., Maack, T., and Lewicki, J. 1987. Receptor interactions of atrial natriuretic peptide ring deletion analogs. Second World Congress on Biologically Active Atrial Peptides. New York. Abst. B173.

  113. Ashwell, G., Harford, J. 1982. Carbohydrate-specific receptors of the liver. Ann. Rev. Biochem. 51:531–554.

    CAS  PubMed  Google Scholar 

  114. Yamamoto, T., Davis, C.G., Brown, M.S., Schneider, W.J., Casey, M.L., Goldstein, J.L., and Russell, D.W. 1984. The human LDL receptor: A cysteine-rich protein with multiple alu sequences in its mRNA. Cell 39:27–38.

    CAS  PubMed  Google Scholar 

  115. McClelland, A., Kuhn, L.C., and Ruddle, F.H. 1984. The human transferrin receptor gene: Genomic organization, and the complete primary structure of the receptor deduced from a cDNA sequence. Cell 39:267–274.

    CAS  PubMed  Google Scholar 

  116. Oka, Y., and Czech, M.P. 1986. The type II insulin-like growth factor receptor is internalized and recycles in the absence of ligand. J. Biol. Chem. 261:9090–9093.

    CAS  PubMed  Google Scholar 

  117. Kuno, T., Andersen, J.W., Kamisaki, Y., Waldman, S.A., Chang, L.Y., Saheki, S., Leitman, D.C., Nakane, M., and Murad, F. 1986. Co-purification of an atrial natriuretic factor receptor and particulate guanylate cyclase from rat lung. J. Biol. Chem. 261:5817–5823.

    CAS  PubMed  Google Scholar 

  118. Takayanagi, R., Inagami, T., Snajdar, R.M., Imada, T., Tamura, M., and Misono, K.S. 1987. Two distinctive forms of receptors for atrial natriuretic factors in bovine adrenocortical cells. J. Biol. Chem. 262:12104–12113.

    CAS  PubMed  Google Scholar 

  119. Shenk, D.B., Phelps, M.N., Porter, J.G., Fuller, F., Cordell, B., and Lewicki, J.A. 1987. Atrial natriuretic peptide receptor: Purification and elucidation of its structural subunit composition. Proc. Natl. Acad. Sci. USA 84:1521–1524.

    Google Scholar 

  120. Hirose, S., Akiyama, F., Shinjo, M., Ohno, H., and Murakami, K. 1985. Solubilization and molecular weight estimation of atrial natriuretic factor receptor from bovine adrenal cortex. Biochem. Biophys. Res. Commun. 130:574–579.

    CAS  PubMed  Google Scholar 

  121. Vandien, K.L., Arcuri, K.E., and Napier, M.A. 1985. Identification of a receptor for atrial natriuretic factor in rabbit aorta membranes by affinity crosslinking. J. Biol. Chem. 260:10889–10922.

    Google Scholar 

  122. Shenk, D.B., Phelps, M., Porter, J.G., Scarborough, R.M., McEnroe, G.A., and Lewicki, J. 1985. Identification of the receptor for atrial natriuretic factor in cultured vascular cells. J. Biol. Chem. 260:14887–14890.

    Google Scholar 

  123. Fuller, F., Porter, J.G., Arfsten, A., Miller, J., Schilling, J., Scarborough, R.M., Lewicki, J., and Schenk, D.B. 1988. Atrial natriuretic peptide C-receptor: Complete sequence and functional expression of cDNA clones. J. Biol. Chem., in press.

  124. Schenk, D., Porter, G., Fuller, F., Arfsten, A., Lewicki, J. 1987. Cloning and expression of the receptor for atrial natriuretic factor. Program of the 2nd World Congress on Biologically Active Atrial Peptides. p. 190.

  125. Raine, A.E.G., Erne, P., Burgisser, E., Muller, F.B., Bolli, P., Burkart, F., and Buhler, F.R. 1986. Atrial natriuretic peptide and atrial pressure in patients with congestive heart failure. N. Engl. J. Med. 315:533–537.

    CAS  PubMed  Google Scholar 

  126. Crozuer, I.G., Nicholls, M.G., Ikram, H., Espiner, E.A., Gomez, H.J., and Warner, N.J. 1986. Haemodynamic effects of atrial peptide infusion in heart failure. Lancet (ii):1242–1245.

  127. Edwards, B.S., Zimmerman, R.S., and Burnett, J.D., Jr. 1987. Atrial natriuretic factor: Physiologic actions and implications in congestive heart failure. Card. Drugs & Therapy 1:89–99.

    CAS  Google Scholar 

  128. Schiffrin, E.L. 1986. Down-regulations of binding sites for atrial natriuretic peptide in platelets of patients with congestive heart failure. Circulation 72:II–463.

    Google Scholar 

  129. Burnett, J.C., Jr. 1987. Atrial natriuretic factor secretion: Physiological regulation and implications in cardiovascular disease. Current Opinion in Cardiology 2:653–659.

    Google Scholar 

  130. Nicklas, J.M., DiCarlo, L.A., Koller, P.T., Morady, F., Diltz, E.A., Shenker, Y., and Grekin, R.J. 1986. Plasma levels of immunoreactive atrial natriuretic factor increase during supraventricular tachycardia. Am. Heart J. 112:923–927.

    CAS  PubMed  Google Scholar 

  131. Achiebinger, R.J. and Linden, J. 1986. Effect of atrial contraction frequency on atrial natriuretic peptide secretion. Am. J. Physiol. 251:H1095–H1099.

    Google Scholar 

  132. Sagnella, G.A., Markandu, N.D., Shore, A., and MacGregor, G.A. 1986. Raiser circulating levels of atrial natriuretic peptides in essential hypertension. Lancet ii:179–181.

    Google Scholar 

  133. Sugawara, A., Nakao, K., Sakamoto, M., Morii, N., Yamada, T., Itoh, H., Shiono, S., and Imura, H. 1985. Plasma concentrations of atrial natriuretic polypeptide in essential hypertension. Lancet ii:1426–1427.

    Google Scholar 

  134. Edwards, B.S., Schwab, T.R., Zimmerman, R.S., Heublein, D.M., Jiang, N.-S., and Burnett, J.C., Jr. 1986. Cardiovascular, renal and endocrine response to atrial natriuretic peptide in angiotensin II mediated hypertension. Circ. Res. 59:663–667.

    CAS  PubMed  Google Scholar 

  135. Zachariah, P.K., Burnett, J.C., Jr., Ritter, S., and Strong, C.G. 1986. Atrial natriuretic peptide in essential hypertension. Clin. Res. 34:489A.

    Google Scholar 

  136. Tanaka, I., and Inagami, T. 1986. Increased concentration of plasma immunoreactive atrial natriuretic factor in Dahl salt sensitive rats with sodium chloride-induced hypertension. J. Hypertension 4:109–112.

    CAS  Google Scholar 

  137. Petterson, A., Ricksten, S.E., Towle, A., Hedner, J., and Hedner, T. 1985. Plasma atrial natriuretic peptide and hemodynamics in conscious normotensive and spontaneously hypertensive rats after acute blood volume expansion. J. Hypertension 3:S311–S313.

    Google Scholar 

  138. Ackermann, D.M., Edwards, B.S., Wold, L.E., and Burnett, J.C., Jr. 1986. Atrial natriuretic peptide: Localization in the human heart. J. Amer. Med. Assoc. 256:1048.

    CAS  Google Scholar 

  139. Shionoiri, H. and Kaneko, Y. 1986. Intranasal administration of alpha-human natriuretic peptide produces a prolonged diuresis in healthy man. Life Sci. 38:773–778.

    CAS  PubMed  Google Scholar 

  140. Su, K.S.E. 1986. Intranasal delivery of peptides and proteins. Pharmacy International 7:8–11.

    CAS  Google Scholar 

  141. DeSchurder, I., Sandaert, A., Germonpre, P., DeBuyzere, M., Delangle, J., and Clement, D. 1987. Hemodynamic effects of atrial natriuretic hormone in congestive heart failure. Cardiovascular Drugs and Therapy 1:226.

    Google Scholar 

  142. Rose, G., Freitag, J., Ling, G., Marder, H., Walker, B. 1987. Effects of anaritide (hANP 102–126) infusions in patients with congestive heart failure. Cardiovascular Drugs and Therapy 1:283.

    Google Scholar 

  143. Gomez, H.J., Smith, R., Warner, M., Mulcaky, W., Nicolodi, L., Smith, S., Irvin, J. 1987. Pharmacological effect and tolerability of atrial natriuretic peptide in man. Cardiovascular Drugs and Therapy 1:242.

    Google Scholar 

  144. Packer, M., Kessler, P.D., and Gottlieb, S.S. 1986. Adverse effects of converting-enzyme inhibition in patients with severe congestive heart failure: Pathophysiology and management. Postgrad. Med. J. 62:179–182.

    PubMed  Google Scholar 

  145. Gunnells, J.C. 1982. Treatment of Systemic Hypertension, p. 1203–1204. In: The Heart. J. W. Hurst (Ed). McGraw Hill, New York.

    Google Scholar 

  146. Brabant, G., Juppner, H., Kirschner, M., Boker, K., Schmidt, F.W., and Hesch, R.D. 1986. Human atrial natriuretic peptide (ANP) for the treatment of patients with liver cirrhosis and ascites. Klin. Wochenschr. 64:108–111.

    PubMed  Google Scholar 

  147. Nakamoto, M., Shapiro, J.I., Stanley, P.F., Chan, L., and Schrier, R.W. 1987. In vitro, and in vivo protective effect of atriopeptin III on ischemic acute renal failure. J. Clin. Invest. 80:698–705.

    CAS  PubMed  PubMed Central  Google Scholar 

  148. Shaw, S., Weidmann, P., Hodler, J., Zimmerman, A., and Puternastro, A. 1987. Atrial natriuretic peptide protects against acute ischemic renal failure in the rat. J. Clin. Invest. 80:1232–1237.

    CAS  PubMed  PubMed Central  Google Scholar 

  149. Cole, B.R., Kuhnline, M.A., and Needleman, P. 1985. Atriopeptin III: A potent natriuretic, diuretic, and hypotensive agent in rats with chronic renal failure. J. Clin. Invest. 76:2413–2415.

    CAS  PubMed  PubMed Central  Google Scholar 

  150. Conger, J.D., Falk, S.A., and Schrier, R.W. 1987. Effects of combined atrial natriuretic factor (ANF) and dopamine (D) on acute renal ischemia. Program of the 20th Annual Meeting of the American Society of Nephrology, p. 112A.

  151. Richards, A.M., Nicholls, M.G., Espiner, E.A., Ikram, H., Yandle, T.G., Joyce, S.L., and Cullens, M.M. 1985. Effects of α-human atrial natriuretic peptide in essential hypertension. Hypertension 7:812–817.

    CAS  PubMed  Google Scholar 

  152. Ortola, F.V., Ballermann, B.J., Anderson, S., Mendez, R.E., Brenner, B.M., Adam, E., Lamm, S., Clarey, L.E., Downes, S.J., Riley, S.L., Sandquist, K.J., and Troy, J.L. 1987. Elevated plasma atrial natriuretic peptide levels in diabetic rats: Potential mediator of hyperfiltration. J. Clin. Invest. 80:670–674.

    CAS  PubMed  PubMed Central  Google Scholar 

  153. Zatz, R., Meyer, T.W., Remke, H.G., and Brenner, B.M. 1985. Predominance of hemodynamic rather than metabolic factors in the pathogenesis of diabetic glomerulopathy. Proc. Natl. Acad. Sci. USA 82:5963–5967.

    CAS  PubMed  PubMed Central  Google Scholar 

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  1. From the Metabolic Research Unit and the Department of Medicine, University of California, San Francisco, CA, 94143

    John D. Baxter, John A. Lewicki & David G. Gardner

  2. California Biotechnology, Inc., 2450 Bayshore Parkway, Mountain View, CA, 94043

    John D. Baxter, John A. Lewicki & David G. Gardner

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Baxter, J., Lewicki, J. & Gardner, D. Atrial Natriuretic Peptide. Nat Biotechnol 6, 529–546 (1988). https://doi.org/10.1038/nbt0588-529

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