Volume 35 Issue 4, April 2017

An oilseed rape field in Denmark. Nour-Eldin et al. (p. 377) show that engineering of transporter genes can translate from the model plant Arabidopsis thaliana to two Brassica oilseed crops to reduce the production of glucosinolates in seeds. Glucosinolate transporter genes were mutated in the polyploid crops Brassica rapa and Brassica juncea. Stable reduction of glucosinolates in seeds was observed in multiple field trials. Image credit: Torben åndahl / Bayer ImageBank (Media number: 00101328)

Editorial

A futile cycle in cell therapy

Should a cell therapy for heart disease with scant evidence of efficacy continue to be tested in humans?

Editorial 11 Apr 2017

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News

Trade groups laud Gottlieb FDA choice, silent on NIH cutback

Mark Ratner
News 11 Apr 2017
'Tinder' for startups

Andrew Marshall
News 11 Apr 2017
National Academies relax stance on germline edits

Cormac Sheridan
News 11 Apr 2017
Allergan dives into CRISPR–Cas9

News 11 Apr 2017
Top heart-failure contender serelaxin flops

News 11 Apr 2017
Real world points to SGLT-2 blockers advantage

News 11 Apr 2017
Oncologists await historic first: a pan-tumor predictive marker, for immunotherapy

Ken Garber
News 11 Apr 2017
Biotech startups woo increasing numbers of crowdfunders

Nuala Moran
News 11 Apr 2017
Around the world in a month

News 11 Apr 2017
Drugmakers accused of exploiting orphan drug incentives, fueling price problem

Brady Huggett
News 11 Apr 2017

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Correspondence

Elevating the conversation about GE crops

Fred Gould
Richard M Amasino
Robert J Whitaker
Correspondence 11 Apr 2017
National Academies report has broad support

Paul Vincelli
Douglas Jackson-Smith
Susan Weller
Correspondence 11 Apr 2017
Response to Gould et al. and Vincelli et al.

Correspondence 11 Apr 2017
Remote detection of buried landmines using a bacterial sensor

Shimshon Belkin
Sharon Yagur-Kroll
Aharon J Agranat
Correspondence 11 Apr 2017
Robotic crowd biology with Maholo LabDroids

Nozomu Yachie
Koichi Takahashi
Tohru Natsume
Correspondence 11 Apr 2017
With all due respect to Maholo, lab automation isn't anthropomorphic

David W McClymont
Paul S Freemont
Correspondence 11 Apr 2017
Toil enables reproducible, open source, big biomedical data analyses

John Vivian
Arjun Arkal Rao
Benedict Paten
Correspondence 11 Apr 2017
Nextflow enables reproducible computational workflows

Paolo Di Tommaso
Maria Chatzou
Cedric Notredame
Correspondence 11 Apr 2017
Reproducible RNA-seq analysis using recount2

Leonardo Collado-Torres
Abhinav Nellore
Jeffrey T Leek

Collection:

The Genotype-Tissue Expression project
Correspondence 11 Apr 2017

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Feature

Nature Biotechnology's academic spinouts of 2016

Our annual survey highlights several academic startups developing immunotherapies as well as ventures focusing on microbiomes, proteostasis, integrin biology, nucleic acid delivery and subcellular imaging.

Aaron Bouchie
Laura DeFrancesco
Sarah Webb
Feature 11 Apr 2017

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Patents

Differing diagnoses for European and US patents

Medical diagnostic patent applications in the United States and Europe face diverging fates following the Supreme Court's decision in Mayo.

Brian Amos
Alan D Miller
Patents 07 Apr 2017
Recent patents in epigenetic targeting

Patents 11 Apr 2017

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News & Views

mHealth advances clinical research, bit by bit

Monitoring the symptoms of a large cohort of asthma patients is made possible by a smartphone app created using Apple ResearchKit.

Joseph C Kvedar
Alexander L Fogel
News & Views 11 Apr 2017
Single-minded CRISPR screening

Transcriptome-wide effects of gene knockouts are screened at the single-cell level by combining high-throughput, single-cell RNA-seq with lentiviral CRISPR libraries.

Bryan R Lanning
Christopher R Vakoc
News & Views 11 Apr 2017
Research Highlights

News & Views 11 Apr 2017
The best spot to park a CAR

Katarzyna Marcinkiewicz
News & Views 11 Apr 2017

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Analysis

Reproducibility of computational workflows is automated using continuous analysis

The application of continuous integration, an approach common in software development, enables the automatic reproduction of computational analyses.

Brett K Beaulieu-Jones
Casey S Greene
Analysis 13 Mar 2017

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Brief Communication

GuideScan software for improved single and paired CRISPR guide RNA design

A tool for genome-wide design of CRISPR guide RNAs reduces off-target effects and facilitates targeting of the non-coding genome.

Alexendar R Perez
Yuri Pritykin
Andrea Ventura
Brief Communication 06 Mar 2017
Prediction of potent shRNAs with a sequential classification algorithm

The most effective shRNAs to silence a gene are calculated by a machine learning algorithm.

Raphael Pelossof
Lauren Fairchild
Christof Fellmann
Brief Communication 06 Mar 2017

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Article

The Asthma Mobile Health Study, a large-scale clinical observational study using ResearchKit

Use of the ResearchKit platform to track symptoms of a large cohort of asthma sufferers over time demonstrates the pros and cons of mobile health applications in large-scale observational studies.

Yu-Feng Yvonne Chan
Pei Wang
Eric E Schadt
Article 13 Mar 2017
A FRET sensor enables quantitative measurements of membrane charges in live cells

The electrostatic potential of the plasma membrane of live mammalian cells is measured with a FRET-based sensor.

Yuanqing Ma
Yui Yamamoto
Katharina Gaus
Article 13 Mar 2017

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Letter

Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions

Genome editing of single bases is made more versatile and accurate with new fusions of mutated Cas9 and cytidine deaminase domains.

Y Bill Kim
Alexis C Komor
David R Liu
Letter 13 Feb 2017
Reduction of antinutritional glucosinolates in Brassica oilseeds by mutation of genes encoding transporters

An antinutritional compound in Brassica seed meal is reduced by knocking out genes encoding transporter proteins.

Hussam Hassan Nour-Eldin
Svend Roesen Madsen
Barbara Ann Halkier
Letter 13 Mar 2017

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Careers and Recruitment

Continuous positive compensation trends indicate a healthy private life sciences sector

Non-founder total target cash compensation in 2016 increased 4.2% year-over-year at private life sciences companies and 6% at private technology companies.

Bruce Rychlik
Careers and Recruitment 11 Apr 2017
People

Careers and Recruitment 11 Apr 2017

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Volume 35 Issue 4, April 2017

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