Volume 35 Issue 3, March 2017

Editorial

The commercial tipping point

RNA-based therapeutics are poised to become successful commercial products, but wide adoption across the biopharmaceutical industry will likely take a few more years.

Focus:

RNA-based therapies
Editorial 27 Feb 2017
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News

Billion-dollar deals end eras of Ariad and Actelion

Melanie Senior
News 07 Mar 2017
CRISPR patents belong to Broad, says USPTO

News 07 Mar 2017
Gender tokenism and bias prevail in biotech boardrooms

Elie Dolgin
News 07 Mar 2017
Merck KGaA lands four Vertex cancer programs

News 07 Mar 2017
Solithromycin rejection chills antibiotic sector

Brian Owens
News 07 Mar 2017
Trump's pick rallies biosimilar makers

News 07 Mar 2017
Biogen pays Forward in Tecfidera dispute

News 07 Mar 2017
Celgene eyes 'inverse vaccines' in Anokion and Delinia deals

Cormac Sheridan
News 07 Mar 2017
New York spreads the news with $1.15 billion biotech plan

Gautam Naik
News 07 Mar 2017

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Podcast

First Rounders podcast: Stephen Quake

Podcast 07 Mar 2017

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News

Around the world in a month

News 07 Mar 2017

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News Feature

The 'anti-hype' vaccine

After years under the radar, RNA vaccines are finally emerging as immunotherapies to combat pandemics and cancer. But as Laura DeFrancesco reports, clinical validation remains elusive.

Laura DeFrancesco

Focus:

RNA-based therapies
News Feature 27 Feb 2017
Worth the RISC?

The long, tortuous race to market a therapeutic based on RNA interference (RNAi) may be nearing its end. Ken Garber reports.

Ken Garber

Focus:

RNA-based therapies
News Feature 27 Feb 2017

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Data Page

Top US universities, institutes for life sciences in 2015

Brady Huggett
Data Page 07 Mar 2017

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Correspondence

US immigration order strikes against biotech

Jeremy M Levin
Steven H Holtzman
Sandford (Sandy) Zweifach
Correspondence 07 Mar 2017
Why axing TPP was a lost opportunity for biotech

Kevin E Noonan
Correspondence 07 Mar 2017
Response to “Railroading at the FDA”

Francesco Muntoni
Sue Fletcher
Steve Wilton
Correspondence 07 Mar 2017

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Patents

Evidence of insufficient quality of reporting in patent landscapes in the life sciences

Despite the importance of patent landscape analyses in the commercialization process for life science and healthcare technologies, the quality of reporting for patent landscapes published in academic journals is inadequate.

James A Smith
Zeeshaan Arshad
David A Brindley
Patents Open Access 07 Mar 2017
Recent patents in chimeric antigen receptors

Patents 07 Mar 2017

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News & Views

Hearing in the mouse of Usher

Hearing and balance are rescued by a synthetic virus that delivers a transgene to the inner ear of neonatal mice.

John V Brigande
News & Views 07 Mar 2017
Fleeting factors, turning back time

Old cells and tissues become young again after a short dose of reprogramming factors.

Thomas A Rando
News & Views 07 Mar 2017
The alleles of a tasty tomato

Katarzyna Marcinkiewicz
News & Views 07 Mar 2017
Research Highlights

News & Views 07 Mar 2017

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Perspective

Overcoming cellular barriers for RNA therapeutics

Recent progress in delivering RNA therapeutics to the inside of cells might lead to more success in clinical applications.

Steven F Dowdy

Collections:

RNA therapies

RNA-based therapies
Perspective 27 Feb 2017
Cellular uptake and trafficking of antisense oligonucleotides

Stanley T Crooke
Shiyu Wang
Xue-hai Liang

Focus:

RNA-based therapies
Perspective 27 Feb 2017

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Review Article

The chemical evolution of oligonucleotide therapies of clinical utility

Refinements in the chemistries employed in oligonucleotide therapeutics have galvanized clinical progress. The complex interplay between chemical modifications and integration into sequence architecture is discussed in the context of antisense and small-interfering RNA drugs.

Anastasia Khvorova
Jonathan K Watts

Collections:

Nature Milestones in Antisense RNA

RNA-based therapies
Review Article 27 Feb 2017
Oligonucleotide therapies for disorders of the nervous system

Brain-targeted oligonucleotide-drugs are poised to treat multiple human central nervous system disorders with an emphasis on rare/orphan conditions.

Olga Khorkova
Claes Wahlestedt

Focus:

RNA-based therapies
Review Article 27 Feb 2017

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Article

Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c

Gene therapy in the inner ear achieves unprecedented recovery of hearing and balance behavior in Usher syndrome mice.

Bifeng Pan
Charles Askew
Gwenaëlle S Géléoc
Article 06 Feb 2017
Dynamic regulation of metabolic flux in engineered bacteria using a pathway-independent quorum-sensing circuit

An inducer-free quorum-sensing circuit is applied to control endogenous bacterial gene expression and improve yields of a range of products.

Apoorv Gupta
Irene M Brockman Reizman
Kristala L J Prather
Article 13 Feb 2017

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Letter

A synthetic AAV vector enables safe and efficient gene transfer to the mammalian inner ear

Efficient gene transfer to the mouse inner ear is achieved with a synthetic adeno-associated viral vector.

Lukas D Landegger
Bifeng Pan
Luk H Vandenberghe

Nature Outlook:

Gene therapy
Letter 06 Feb 2017

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Careers and Recruitment

International mentoring as a new educational approach to alleviate brain drain, empower young talent, and internationalize higher education

A novel program shows that young professionals working abroad can be instrumental in their home country's development.

María Soriano-Carot
Rosa Bretón-Romero
Zafira Castano

Career Guide:

Mentoring resources for scientists
Careers and Recruitment 07 Mar 2017
People

Careers and Recruitment 07 Mar 2017

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In This Issue

In this issue

In This Issue 07 Mar 2017

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Volume 35 Issue 3, March 2017

Editorial

News

Podcast

News

News Feature

Data Page

Correspondence

Patents

News & Views

Perspective

Review Article

Article

Letter

Careers and Recruitment

In This Issue

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