Papers from the literature selected by the Nature Biotechnology editors. (Follow us on Twitter, @NatureBiotech #nbtHighlight)

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

Punjani, A. Rubinstein, J.L., Fleet, D.J. & Brubaker, M.A. Nat. Methods. 10.1038/nmeth.4169 (2017)

Dermatologist-level classification of skin cancer with deep neural networks

Esteva, A. et al. Nature 542, 115–118 (2017)

Systemic immunity is required for effective cancer immunotherapy

Spitzer, M.H. et al. Cell 168, 487–502 (2017)

Ligand and target discovery by fragment-based screening in human cells

Parker, C.G. et al. Cell 168, 527–541 (2017)

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

DeVos, S.L. et al. Sci. Transl. Med. 10.1126/scitranslmed.aag0481 (2017)