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Volume 34 Issue 1, January 2016

A newly emerged female Anopheles gambiae mosquito is shown, resting on water before its first flight. Andrew Hammond and colleagues (p 78) develop a CRISPR-Cas9-based gene drive system that targets female fertility in Anopheles gambiae, the main vector for the malaria parasite. This paves the way for the development of efficient gene drives that could suppress mosquito populations. Photographers: Andrew Hammond and Alekos Simoni.

Volume 34 Issue 1

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Editorial

  • Will targeted immunosuppressants and new tools in genome engineering be enough to finally give xenopigs wings?

    Editorial

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News

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News Feature

  • Electronic drugs and delivery systems are reaching the market, giving drug developers and healthcare providers a way to improve patient compliance and more. Emily Waltz reports.

    • Emily Waltz
    News Feature
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Bioentrepreneur

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Correspondence

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Commentary

  • The markets may be softening on biotech, but overall the sector remains in an incredibly strong environment.

    • Bruce L Booth
    Commentary
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Feature

  • Although a few arable crops and agronomic traits will likely dominate commercial varieties for the foreseeable future, with many being stacked together, more quality traits and specialty crops are being introduced into the pipeline.

    • Claudia Parisi
    • Pascal Tillie
    • Emilio Rodríguez-Cerezo
    Feature
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Patents

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News & Views

  • A method for generating serotonin raphe neurons in vitro will aid the study of genetic variants and drugs that modulate serotonin activity.

    • Patricia Gaspar
    • Stéphane Nedelec
    News & Views

  • Two recent studies report the development of miniaturized, fully-implantable devices that enable wireless optogenetic neuromodulation in peripheral nerves and spinal cord.

    • Polina Anikeeva
    News & Views

  • Understanding the full breadth of immune responses that protect against HIV-1 may speed vaccine development.

    • Tianlei Ying
    • Ponraj Prabakaran
    • Dimiter S Dimitrov
    News & Views
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Analysis

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Perspective

  • The unprecedented number of fatalities in the PROPATRIA clinical trial using probiotics to treat patients with acute pancreatitis cast a shadow over the field. Bongaerts et al. provide rationales for the trial's high mortality rate and outline situations in which probiotic therapy may still be appropriate for this disease.

    • Ger P A Bongaerts
    • René S V M Severijnen
    Perspective
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