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Volume 29 Issue 8, August 2011

Chinese hamster ovary cells in culture, imaged with an atomic force microscope. Palsson, Wang and colleagues have sequenced the genome of cells from the CHO-K1 line (pictured), an ancestor of cell lines widely used to produce therapeutic proteins (p 735). Credit: Hermann Schillers, University of Münster, Münster, Germany.

Volume 29 Issue 8

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Editorial

  • The US Food and Drug Administration (FDA) should follow its advisory panels and rescind metastatic breast cancer from Avastin's label.

    Editorial

    Advertisement

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News

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Data Page

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News Feature

  • A new technology for genome editing may put the zinc finger nuclease franchise out of business, some believe. Not so fast, say the finger people. Laura DeFrancesco reports.

    News Feature
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Correspondence

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Commentary

  • Despite being caught up in regulatory proceedings for 15 years or more, AquAdvantage salmon, the first animal genetically engineered (GE) for food purposes, continues to raise concerns. Are any of these concerns scientifically justified?

    • Alison L Van Eenennaam
    • William M Muir
    Commentary
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Patents

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News & Views

  • High-resolution linkage analysis enabled by transcriptome sequencing brings order to the genome of a polyploid crop.

    • John K McKay
    • Jan E Leach
    News & Views

  • An ancestor of the Chinese hamster ovary cell lines used for production of recombinant therapeutics has been sequenced.

    • Florian M Wurm
    • David Hacker
    News & Views
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Research Highlights

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Analysis

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Brief Communication

  • Transcription activator–like effector nucleases (TALENs) are a new technology for modifying the genome at specific loci of interest. Hockemeyer et al. now demonstrate the utility of TALENs for gene targeting in human pluripotent stem cells.

    • Dirk Hockemeyer
    • Haoyi Wang
    • Rudolf Jaenisch
    Brief Communication
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Article

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Letter

  • Fluorescent proteins with excitation and emission maxima in the near-infrared would be especially useful because of the low light absorbance of mammalian tissues in this optical window. Verkhusha and colleagues present a bright, photostable fluorescent protein with optimized near-infrared spectra that does not require the addition of exogenous co-factors.

    • Grigory S Filonov
    • Kiryl D Piatkevich
    • Vladislav V Verkhusha
    Letter

  • Cost-effective analysis of allelic variation can be problematic for polyploid crops. By sequencing leaf transcriptomes from a mapping population of oilseed rape and its progenitors, Bancroft et al. provide a general strategy to construct linkage maps for comparative genome analysis.

    • Ian Bancroft
    • Colin Morgan
    • Martin Trick
    Letter
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Careers and Recruitment

  • Careers and Recruitment
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