Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 27 Issue 4, April 2009

Padlock probes bound to bisulfitetreated genomic DNA in which cytosine residues (red) that are not methylated have been converted to uracils. Deng et al. and Ball et al. use customized padlock probes and next-generation sequencing to identify differences in DNA methylation between induced pluripotent stem cells and the fibroblasts from which they were derived (p 353, p 361).

Volume 27 Issue 4

Subscribe

Editorial

  • If there is one thing that the new team at the US Food and Drug Administration should immediately implement, it is a comprehensive, open database of drug-related adverse events.

    Editorial

    Advertisement

Top of page ⤴

News

Top of page ⤴

Profile

  • Meet the man behind Pfizer's recent decision to bet its entire R&D effort on the biotech model.

    • Jim Kling
    Profile
Top of page ⤴

News Feature

  • A gout drug has been approved by the FDA, the first in 40 years, with three more in the wings. What accounts for this sudden slew of gout therapies? Jill U. Adams investigates.

    • Jill U Adams
    News Feature
Top of page ⤴

Correspondence

Top of page ⤴

Commentary

Top of page ⤴

Book Review

Top of page ⤴

Feature

  • Although fewer antibody fragments have entered the clinic than full-length monoclonal antibodies, proof-of-concept studies for these therapeutics remain the main hurdle.

    • Aaron L Nelson
    • Janice M Reichert
    Feature
Top of page ⤴

Patents

Top of page ⤴

News & Views

  • Two groups have combined padlock probes and massively parallel sequencing to characterize cytosine methylation in targeted regions of the human genome.

    • Benjamin P Berman
    • Daniel J Weisenberger
    • Peter W Laird
    News & Views

  • The MoBY-ORF collection of barcoded yeast genes provides mechanistic insights into antiproliferative compounds.

    • Deming Xu
    • Terry Roemer
    News & Views
Top of page ⤴

Research Highlights

Top of page ⤴

Primer

  • Only a subset of single-nucleotide polymorphisms (SNPs) can be genotyped in genome-wide association studies. Imputation methods can infer the alleles of 'hidden' variants and use those inferences to test the hidden variants for association.

    • Eran Halperin
    • Dietrich A Stephan

    Collection:

    Primer
Top of page ⤴

Article

Top of page ⤴

Careers and Recruitment

Top of page ⤴

People

Top of page ⤴

Search

Advanced search

Quick links