Table of contents
December 2007, Volume 25 No 12 pp1329-1492
- In This Issue
- Focus
- Editorials
- News
- Bioentrepreneur
- Opinion and Comment
- News and Views
- Editorial
- News
- Opinion and Comment
- Features
- Computational Biology
- Research
- Letters
- Naturejobs
Focus
Focus on Antivirals
- Focus issue:
- December 2007 Volume 25, No 12
This issue provides several articles focusing on antiviral therapy. Additional material, brought together in a joint focus with Nature Reviews Drug Discovery supported by our principal sponsor Pfizer and our supporting sponsor Gilead, is also available by clicking on the link to “Joint Focus” above.
Editorials
Stop the cull - p1329
doi:10.1038/nbt1207-1329
Abstract - Stop the cull | Full Text - Stop the cull | PDF (104 KB) - Stop the cull
Another inconvenient truth - p1330
doi:10.1038/nbt1207-1330
Abstract - Another inconvenient truth | Full Text - Another inconvenient truth | PDF (48 KB) - Another inconvenient truth
News
Pfizer dumps Exubera - pp1331 - 1332
George S. Mack
doi:10.1038/nbt1207-1331
Full Text - Pfizer dumps Exubera | PDF (145 KB) - Pfizer dumps Exubera
Proposed changes to patent code loom over biotech industry - pp1333 - 1334
Amy Coombs
doi:10.1038/nbt1207-1333
Full Text - Proposed changes to patent code loom over biotech industry | PDF (192 KB) - Proposed changes to patent code loom over biotech industry
Biogen Idec goes on the auction block - pp1335 - 1336
Randall Osborne
doi:10.1038/nbt1207-1335
Full Text - Biogen Idec goes on the auction block | PDF (200 KB) - Biogen Idec goes on the auction block
Chinese manufacturers vie for piece of outsourcing pie - pp1337 - 1338
Hepeng Jia
doi:10.1038/nbt1207-1337
Full Text - Chinese manufacturers vie for piece of outsourcing pie | PDF (275 KB) - Chinese manufacturers vie for piece of outsourcing pie
In Brief
News in brief - pp1339 - 1340
doi:10.1038/nbt1207-1339
Data Pages
Biotech patents still strong - p1341
Stacy Lawrence
doi:10.1038/nbt1207-1341
Full Text - Biotech patents still strong | PDF (122 KB) - Biotech patents still strong
Pipelines turn to biotech - p1342
Stacy Lawrence
doi:10.1038/nbt1207-1342
Full Text - Pipelines turn to biotech | PDF (123 KB) - Pipelines turn to biotech
News Feature
Biotech for your companion? - pp1343 - 1345
Jim Kling
doi:10.1038/nbt1207-1343
Abstract - Biotech for your companion? | Full Text - Biotech for your companion? | PDF (224 KB) - Biotech for your companion?
Bioentrepreneur
Building a business
Best practices in patent license negotiations - pp1347 - 1349
Jennifer Giordano-Coltart & Charles W Calkins
doi:10.1038/bioe.2007.5
PDF (110 KB) - Best practices in patent license negotiations
Opinion and Comment
Correspondence
GM soybeans—revisiting a controversial format - pp1351 - 1354
Irina V. Ermakova
doi:10.1038/nbt1207-1351
Full Text - GM soybeans—revisiting a controversial format | PDF (190 KB) - GM soybeans—revisiting a controversial format
GM soybeans—revisiting a controversial format - pp1354 - 1355
Brian John
doi:10.1038/nbt1207-1354
Full Text - GM soybeans—revisiting a controversial format | PDF (87 KB) - GM soybeans—revisiting a controversial format
GM soybeans—revisiting a controversial format - p1355
Mae-Wan Ho & Peter T Saunders
doi:10.1038/nbt1207-1355a
Full Text - GM soybeans—revisiting a controversial format | PDF (70 KB) - GM soybeans—revisiting a controversial format
GM soybeans—revisiting a controversial format - p1355
Carlo Leifert
doi:10.1038/nbt1207-1355b
Full Text - GM soybeans—revisiting a controversial format | PDF (70 KB) - GM soybeans—revisiting a controversial format
GM soybeans—revisiting a controversial format - pp1355 - 1356
Jack A Heinemann & Terje Traavik
doi:10.1038/nbt1207-1355c
Full Text - GM soybeans—revisiting a controversial format | PDF (89 KB) - GM soybeans—revisiting a controversial format
GM soybeans—revisiting a controversial format - p1356
Joe Cummins
doi:10.1038/nbt1207-1356a
Full Text - GM soybeans—revisiting a controversial format | PDF (69 KB) - GM soybeans—revisiting a controversial format
Response to GM soybeans—revisiting a controversial format - pp1356 - 1358
doi:10.1038/nbt1207-1356b
Full Text - Response to GM soybeans—revisiting a controversial format | PDF (148 KB) - Response to GM soybeans—revisiting a controversial format
Response to GM soybeans—revisiting a controversial format - pp1359 - 1360
doi:10.1038/nbt1207-1359
Full Text - Response to GM soybeans—revisiting a controversial format | PDF (82 KB) - Response to GM soybeans—revisiting a controversial format | Supplementary information
Commentary
Bridging the knowledge gaps in vaccine design - pp1361 - 1366
Rino Rappuoli
doi:10.1038/nbt1207-1361
Abstract - Bridging the knowledge gaps in vaccine design | Full Text - Bridging the knowledge gaps in vaccine design | PDF (386 KB) - Bridging the knowledge gaps in vaccine design
News and Views
Fungal bioinsecticide with a sting - pp1367 - 1368
Matthew B Thomas & Andrew F Read
doi:10.1038/nbt1207-1367
Abstract - Fungal bioinsecticide with a sting | Full Text - Fungal bioinsecticide with a sting | PDF (405 KB) - Fungal bioinsecticide with a sting
See also: Research by Wang & St Leger
Isotype selection in antibody engineering - pp1369 - 1372
Jochen G Salfeld
doi:10.1038/nbt1207-1369
Abstract - Isotype selection in antibody engineering | Full Text - Isotype selection in antibody engineering | PDF (683 KB) - Isotype selection in antibody engineering
Research highlights - p1373
doi:10.1038/nbt1207-1373
Full Text - Research highlights | PDF (131 KB) - Research highlights
Editorial
Antivirals
Beyond interferon - p1375
doi:10.1038/nbt1207-1375
Abstract - Beyond interferon | Full Text - Beyond interferon | PDF (126 KB) - Beyond interferon
News
Profile
Antivirals
Ian Frazer - p1377
Mark Ratner
doi:10.1038/nbt1207-1377
Abstract - Ian Frazer | Full Text - Ian Frazer | PDF (94 KB) - Ian Frazer
News Feature
Antivirals
Hepatitis C: staying the course - pp1379 - 1381
Ken Garber
doi:10.1038/nbt1207-1379
Abstract - Hepatitis C: staying the course | Full Text - Hepatitis C: staying the course | PDF (223 KB) - Hepatitis C: staying the course
Opinion and Comment
Commentary
Antivirals
Systems biology and the host response to viral infection - pp1383 - 1389
Seng-Lai Tan, Gopinath Ganji, Bryan Paeper, Sean Proll & Michael G Katze
doi:10.1038/nbt1207-1383
Abstract - Systems biology and the host response to viral infection | Full Text - Systems biology and the host response to viral infection | PDF (863 KB) - Systems biology and the host response to viral infection
Antivirals
Antivirals—an increasingly healthy investment - pp1390 - 1393
Brian McCarthy
doi:10.1038/nbt1207-1390
Abstract - Antivirals—an increasingly healthy investment | Full Text - Antivirals—an increasingly healthy investment | PDF (149 KB) - Antivirals—an increasingly healthy investment
Feature
Antivirals
Antivirals become a broader enterprise - pp1395 - 1402
Jeffrey L Fox
doi:10.1038/nbt1207-1395
Abstract - Antivirals become a broader enterprise | Full Text - Antivirals become a broader enterprise | PDF (1,034 KB) - Antivirals become a broader enterprise
Patents
Antivirals
Patentability issues surrounding antivirals - pp1403 - 1404
Deborah L Lu, Angela M Collison & Thomas J Kowalski
doi:10.1038/nbt1207-1403
Abstract - Patentability issues surrounding antivirals | Full Text - Patentability issues surrounding antivirals | PDF (101 KB) - Patentability issues surrounding antivirals
Antivirals
Recent patent applications in antivirals - p1405
doi:10.1038/nbt1207-1405
Full Text - Recent patent applications in antivirals | PDF (44 KB) - Recent patent applications in antivirals
Computational Biology
Commentary
Antivirals
Bioinformatics prediction of HIV coreceptor usage - pp1407 - 1410
Thomas Lengauer, Oliver Sander, Saleta Sierra, Alexander Thielen & Rolf Kaiser
doi:10.1038/nbt1371
Abstract - Bioinformatics prediction of HIV coreceptor usage | Full Text - Bioinformatics prediction of HIV coreceptor usage | PDF (265 KB) - Bioinformatics prediction of HIV coreceptor usage
Research
Perspective
Antivirals
Albinterferon α-2b: a genetic fusion protein for the treatment of chronic hepatitis C - pp1411 - 1419
G Mani Subramanian, Michele Fiscella, Araba Lamousé-Smith, Stefan Zeuzem & John G McHutchison
doi:10.1038/nbt1364
Abstract - Albinterferon α-2b: a genetic fusion protein for the treatment of chronic hepatitis C | Full Text - Albinterferon α-2b: a genetic fusion protein for the treatment of chronic hepatitis C | PDF (587 KB) - Albinterferon α-2b: a genetic fusion protein for the treatment of chronic hepatitis C
Reviews
Antivirals
The growth and potential of human antiviral monoclonal antibody therapeutics - pp1421 - 1434
Wayne A Marasco & Jianhua Sui
doi:10.1038/nbt1363
Abstract - The growth and potential of human antiviral monoclonal antibody therapeutics | Full Text - The growth and potential of human antiviral monoclonal antibody therapeutics | PDF (1,329 KB) - The growth and potential of human antiviral monoclonal antibody therapeutics
Antivirals
RNA interference against viruses: strike and counterstrike - pp1435 - 1443
Joost Haasnoot, Ellen M Westerhout & Ben Berkhout
doi:10.1038/nbt1369
Abstract - RNA interference against viruses: strike and counterstrike | Full Text - RNA interference against viruses: strike and counterstrike | PDF (1,086 KB) - RNA interference against viruses: strike and counterstrike
Antivirals
Genetic therapies against HIV - pp1444 - 1454
John J Rossi, Carl H June & Donald B Kohn
doi:10.1038/nbt1367
Abstract - Genetic therapies against HIV | Full Text - Genetic therapies against HIV | PDF (1,879 KB) - Genetic therapies against HIV
Brief Communication
A scorpion neurotoxin increases the potency of a fungal insecticide - pp1455 - 1456
Chengshu Wang & Raymond J St Leger
doi:10.1038/nbt1357
First paragraph - A scorpion neurotoxin increases the potency of a fungal insecticide | Full Text - A scorpion neurotoxin increases the potency of a fungal insecticide | PDF (210 KB) - A scorpion neurotoxin increases the potency of a fungal insecticide | Supplementary information
See also: News and Views by Thomas & Read
Articles
Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state - pp1457 - 1467
Brian D Brown, Bernhard Gentner, Alessio Cantore, Silvia Colleoni, Mario Amendola, Anna Zingale, Alessia Baccarini, Giovanna Lazzari, Cesare Galli & Luigi Naldini
doi:10.1038/nbt1372
Abstract - Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state | Full Text - Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state | PDF (1,476 KB) - Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state | Supplementary information
Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells - pp1468 - 1475
Gabsang Lee, Hyesoo Kim, Yechiel Elkabetz, George Al Shamy, Georgia Panagiotakos, Tiziano Barberi, Viviane Tabar & Lorenz Studer
doi:10.1038/nbt1365
Abstract - Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells | Full Text - Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells | PDF (764 KB) - Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells | Supplementary information
Letters
Identification and targeting of the ROSA26 locus in human embryonic stem cells - pp1477 - 1482
Stefan Irion, Hervé Luche, Paul Gadue, Hans Joerg Fehling, Marion Kennedy & Gordon Keller
doi:10.1038/nbt1362
First paragraph - Identification and targeting of the : ROSA26: locus in human embryonic stem cells | Full Text - Identification and targeting of the ROSA26 locus in human embryonic stem cells | PDF (434 KB) - Identification and targeting of the ROSA26 locus in human embryonic stem cells | Supplementary information
Redirecting lipoic acid ligase for cell surface protein labeling with small-molecule probes - pp1483 - 1487
Marta Fernández-Suárez, Hemanta Baruah, Laura Martínez-Hernández, Kathleen T Xie, Jeremy M Baskin, Carolyn R Bertozzi & Alice Y Ting
doi:10.1038/nbt1355
First paragraph - Redirecting lipoic acid ligase for cell surface protein labeling with small-molecule probes | Full Text - Redirecting lipoic acid ligase for cell surface protein labeling with small-molecule probes | PDF (308 KB) - Redirecting lipoic acid ligase for cell surface protein labeling with small-molecule probes | Supplementary information
Errata
Erratum: Funding crunch forces stem cell company to abandon therapies - p1488
Monya Baker
doi:10.1038/nbt1207-1488a
Full Text - Erratum: Funding crunch forces stem cell company to abandon therapies | PDF (57 KB) - Erratum: Funding crunch forces stem cell company to abandon therapies
Erratum: Mice with a human touch - p1488
Christopher Thomas Scott
doi:10.1038/nbt1207-1488b
Full Text - Erratum: Mice with a human touch | PDF (57 KB) - Erratum: Mice with a human touch
Erratum: Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria - p1488
Russell P Rother, Scott A Rollins, Christopher F Mojcik, Robert A Brodsky & Leonard Bell
doi:10.1038/nbt1207-1488c
Full Text - Erratum: Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria | PDF (57 KB) - Erratum: Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria
Corrigenda
Corrigendum: A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments - p1488
Yougen Li, D Allan Drummond, Andrew M Sawayama, Christopher D Snow, Jesse D Bloom & Frances H Arnold
doi:10.1038/nbt1207-1488d
Full Text - Corrigendum: A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments | PDF (57 KB) - Corrigendum: A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments
Naturejobs
Careers and Recruitment
Management consulting for scientists - pp1489 - 1490
Samarth Kulkarni
doi:10.1038/nbt1207-1489
Abstract - Management consulting for scientists | Full Text - Management consulting for scientists | PDF (94 KB) - Management consulting for scientists
