Figure 5 - Human Disease Network and drug targets.


From the following article

Drug—target network

Muhammed A Yi nodotldi nodotri nodotm, Kwang-Il Goh, Michael E Cusick, Albert-László Barabási & Marc Vidal

Nature Biotechnology 25, 1119 - 1126 (2007) Published online: 5 October 2007

doi:10.1038/nbt1338

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(a) The Human Disease Network was generated from OMIM-based disorder–disease gene associations10, where circles and rectangles correspond to disorders and disease genes, respectively. A link is placed between a disorder and a disease gene if mutations in that gene lead to the specific disorder. Disease genes associated only with a single disease are not shown for clarity. The drug targets are marked by larger boxes in the map, and they are colored either black or tan corresponding to targets of approved and experimental drugs, respectively. Disease categories that are preferentially associated with genes and that are also frequent drug targets are endocrine, hematological, cardiovascular and psychiatric. In contrast, cancer, muscular, skeletal, gastrointestinal and dermatological disease categories are associated with fewer drug targets than average (Supplementary Fig. 6c). (b) Average degree of several gene classes in the human disease gene HDG network10. (c) Fraction of target proteins while applying a breadth-first search starting from either a target protein or a random protein in the HDG network with respect to distance.

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