News in brief - pp9 - 10

doi:10.1038/nbt0107-9

Full Text - News in brief | PDF (495 KB) - News in brief

Profile: Edmund D Pellegrino - p11

Kendall Powell

doi:10.1038/nbt0107-11

Abstract - Profile: Edmund D Pellegrino | Full Text - Profile: Edmund D Pellegrino | PDF (146 KB) - Profile: Edmund D Pellegrino

Biotech as an employer - p12

Stacy Lawrence

doi:10.1038/nbt0107-12

Full Text - Biotech as an employer | PDF (133 KB) - Biotech as an employer

The policy outlook from the Hill - pp13 - 16

Brian Vastag

doi:10.1038/nbt0107-13

Abstract - The policy outlook from the Hill | Full Text - The policy outlook from the Hill | PDF (1,096 KB) - The policy outlook from the Hill

HDAC inhibitors overcome first hurdle - pp17 - 19

Ken Garber

doi:10.1038/nbt0107-17

Abstract - HDAC inhibitors overcome first hurdle | Full Text - HDAC inhibitors overcome first hurdle | PDF (401 KB) - HDAC inhibitors overcome first hurdle

How the EU can fund your company - pp21 - 24

Natasha Gilbert

doi:10.1038/bioent914

PDF (208 KB) - How the EU can fund your company

Statistical methods and microarray data - pp25 - 26

Lev Klebanov, Xing Qiu, Stephen Welle & Andrei Yakovlev

doi:10.1038/nbt0107-25

Full Text - Statistical methods and microarray data | PDF (834 KB) - Statistical methods and microarray data

Reply to Statistical methods and microarray data - pp26 - 27

doi:10.1038/nbt0107-26

Full Text - Reply to Statistical methods and microarray data | PDF (833 KB) - Reply to Statistical methods and microarray data

MAQC papers over the cracks - pp27 - 28

Peng Liang

doi:10.1038/nbt0107-27

Full Text - MAQC papers over the cracks | PDF (832 KB) - MAQC papers over the cracks

Reply to MAQC papers over the cracks - pp28 - 29

doi:10.1038/nbt0107-28

Full Text - Reply to MAQC papers over the cracks | PDF (497 KB) - Reply to MAQC papers over the cracks

Unrealistic expectations for IR microspectroscopic imaging - pp29 - 31

Jens Einenkel, Wolfram Steller, Ulf-Dietrich Braumann, Lars-Christian Horn & Christoph Krafft

doi:10.1038/nbt0107-29

Full Text - Unrealistic expectations for IR microspectroscopic imaging | PDF (2,098 KB) - Unrealistic expectations for IR microspectroscopic imaging

Reply to Unrealistic expectations for IR microspectroscopic imaging - pp31 - 33

doi:10.1038/nbt0107-31

Full Text - Reply to Unrealistic expectations for IR microspectroscopic imaging | PDF (2,023 KB) - Reply to Unrealistic expectations for IR microspectroscopic imaging

Parallel biopolitical universes - pp33 - 34

Shane H Morris

doi:10.1038/nbt0107-33

Full Text - Parallel biopolitical universes | PDF (1,027 KB) - Parallel biopolitical universes

Early-tier tests insufficient for GMO risk assessment - pp35 - 36

Andreas Lang, Éva Lauber & Béla Darvas

doi:10.1038/nbt0107-35

Full Text - Early-tier tests insufficient for GMO risk assessment | PDF (445 KB) - Early-tier tests insufficient for GMO risk assessment

Reply to Early-tier tests insufficient for GMO risk assessment - pp36 - 37

doi:10.1038/nbt0107-36

Full Text - Reply to Early-tier tests insufficient for GMO risk assessment | PDF (75 KB) - Reply to Early-tier tests insufficient for GMO risk assessment

Animal cloning and the FDA—the risk assessment paradigm under public scrutiny - pp39 - 43

Larisa Rudenko, John C Matheson & Stephen F Sundlof

doi:10.1038/nbt0107-39

Abstract - Animal cloning and the FDA[mdash]the risk assessment paradigm under public scrutiny | Full Text - Animal cloning and the FDA—the risk assessment paradigm under public scrutiny | PDF (1,397 KB) - Animal cloning and the FDA—the risk assessment paradigm under public scrutiny

The Ten Commandments for biotech investors - p44

Tom Jacobs

doi:10.1038/nbt0107-44

Full Text - The Ten Commandments for biotech investors | PDF (57 KB) - The Ten Commandments for biotech investors

Biotech's promise, delayed - p45

doi:10.1038/nbt0107-45

Full Text - Biotech's promise, delayed | PDF (294 KB) - Biotech's promise, delayed

Japan's novelty grace period solves the dilemma of 'publish and perish' - pp55 - 57

John A Tessensohn & Shusaku Yamamoto

doi:10.1038/nbt0107-55

Abstract - Japan's novelty grace period solves the dilemma of 'publish and perish' | Full Text - Japan's novelty grace period solves the dilemma of 'publish and perish' | PDF (127 KB) - Japan's novelty grace period solves the dilemma of 'publish and perish'

Recent patent applications in antibodies - p58

doi:10.1038/nbt0107-58

Full Text - Recent patent applications in antibodies | PDF (37 KB) - Recent patent applications in antibodies

Structure-based maximal affinity model predicts small-molecule druggability - pp71 - 75

Alan C Cheng, Ryan G Coleman, Kathleen T Smyth, Qing Cao, Patricia Soulard, Daniel R Caffrey, Anna C Salzberg & Enoch S Huang

doi:10.1038/nbt1273

Abstract - Structure-based maximal affinity model predicts small-molecule druggability | Full Text - Structure-based maximal affinity model predicts small-molecule druggability | PDF (468 KB) - Structure-based maximal affinity model predicts small-molecule druggability | Supplementary information

Risk assessment of meat and milk from cloned animals - pp77 - 83

Xiangzhong Yang, X Cindy Tian, Chikara Kubota, Ray Page, Jie Xu, Jose Cibelli & George Seidel, Jr

doi:10.1038/nbt1276

Abstract - Risk assessment of meat and milk from cloned animals | Full Text - Risk assessment of meat and milk from cloned animals | PDF (189 KB) - Risk assessment of meat and milk from cloned animals | Supplementary information

Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug - pp84 - 90

Paul A Marks & Ronald Breslow

doi:10.1038/nbt1272

Abstract - Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug | Full Text - Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug | PDF (571 KB) - Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug

F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses - pp91 - 99

William T Poueymirou, Wojtek Auerbach, David Frendewey, Joseph F Hickey, Jennifer M Escaravage, Lakeisha Esau, Anthony T Doré, Sean Stevens, Niels C Adams, Melissa G Dominguez, Nicholas W Gale, George D Yancopoulos, Thomas M DeChiara & David M Valenzuela

doi:10.1038/nbt1263

Abstract - F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses | Full Text - F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses | PDF (505 KB) - F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses | Supplementary information

See also: News and Views by Gridley & Woychik

Isolation of amniotic stem cell lines with potential for therapy - pp100 - 106

Paolo De Coppi, Georg Bartsch, Jr, M Minhaj Siddiqui, Tao Xu, Cesar C Santos, Laura Perin, Gustavo Mostoslavsky, Angéline C Serre, Evan Y Snyder, James J Yoo, Mark E Furth, Shay Soker & Anthony Atala

doi:10.1038/nbt1274

Abstract - Isolation of amniotic stem cell lines with potential for therapy | Full Text - Isolation of amniotic stem cell lines with potential for therapy | PDF (387 KB) - Isolation of amniotic stem cell lines with potential for therapy | Supplementary information

See also: News and Views by Trounson

Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin - pp107 - 116

Consuelo Garcia-Rodriguez, Raphael Levy, Joseph W Arndt, Charles M Forsyth, Ali Razai, Jianlong Lou, Isin Geren, Raymond C Stevens & James D Marks

doi:10.1038/nbt1269

Abstract - Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin | Full Text - Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin | PDF (843 KB) - Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin | Supplementary information

See also: News and Views by Presta

Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation - pp117 - 124

Peng Lu, Christine Vogel, Rong Wang, Xin Yao & Edward M Marcotte

doi:10.1038/nbt1270

Abstract - Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation | Full Text - Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation | PDF (1,644 KB) - Absolute protein expression profiling estimates the relative contributions of transcriptional and translational regulation | Supplementary information

See also: News and Views by Bergeron & Hallett

Computational prediction of proteotypic peptides for quantitative proteomics - pp125 - 131

Parag Mallick, Markus Schirle, Sharon S Chen, Mark R Flory, Hookeun Lee, Daniel Martin, Jeffrey Ranish, Brian Raught, Robert Schmitt, Thilo Werner, Bernhard Kuster & Ruedi Aebersold

doi:10.1038/nbt1275

First paragraph - Computational prediction of proteotypic peptides for quantitative proteomics | Full Text - Computational prediction of proteotypic peptides for quantitative proteomics | PDF (381 KB) - Computational prediction of proteotypic peptides for quantitative proteomics | Supplementary information

See also: News and Views by Bergeron & Hallett

Production of cattle lacking prion protein - pp132 - 138

Jürgen A Richt, Poothappillai Kasinathan, Amir N Hamir, Joaquin Castilla, Thillai Sathiyaseelan, Francisco Vargas, Janaki Sathiyaseelan, Hua Wu, Hiroaki Matsushita, Julie Koster, Shinichiro Kato, Isao Ishida, Claudio Soto, James M Robl & Yoshimi Kuroiwa

doi:10.1038/nbt1271

Abstract - Production of cattle lacking prion protein | Full Text - Production of cattle lacking prion protein | PDF (406 KB) - Production of cattle lacking prion protein | Supplementary information

Masters of efficiency - pp139 - 140

Hannah Hoag

doi:10.1038/nbt0107-139

Abstract - Masters of efficiency | Full Text - Masters of efficiency | PDF (449 KB) - Masters of efficiency

People - p142

doi:10.1038/nbt0107-142

Full Text - People | PDF (358 KB) - People