Nature Biotechnology
- 24, 1255 - 1256 (2006)
Published online: 17 September 2006; | doi:10.1038/nbt1245
Efficient enucleation of erythroblasts differentiated in vitro from hematopoietic stem and progenitor cellsKenichi Miharada1, 2, Takashi Hiroyama1, Kazuhiro Sudo1, Toshiro Nagasawa2 & Yukio Nakamura11
Cell Engineering Division, RIKEN BioResource Center, Koyadai 3-1-1, Tsukuba, Ibaraki 305-0074, Japan. 2
Division of Hematology, Institute of Clinical Medicine, University of Tsukuba, Ten-nodai 1-1-1, Tsukuba, Ibaraki 305-8577, Japan.
Correspondence should be addressed to Yukio Nakamura yukionak@brc.riken.jp Erythroblast enucleation is thought to be largely dependent on signals mediated by other cells, such as macrophages. In an attempt to improve the in vitro production of red blood cells (RBCs) from immature hematopoietic progenitor cells, we have developed a method to produce enucleated RBCs efficiently in the absence of feeder cells. Our method may represent an efficient way to produce transfusable RBCs on a large scale from hematopoietic progenitors.
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