Nature Biotechnology
- 24, 1257 - 1262 (2006)
Published online: 10 September 2006; Corrected online: 30 March 2007 | doi:10.1038/nbt1244
There is a Corrigendum (April 2007) associated with this Article.
Genome sequence of the bioplastic-producing "Knallgas" bacterium Ralstonia eutropha H16Anne Pohlmann1, 5, Wolfgang Florian Fricke2, 4, 5, Frank Reinecke3, 5, Bernhard Kusian4, Heiko Liesegang2, Rainer Cramm1, Thomas Eitinger1, Christian Ewering3, Markus Pötter3, Edward Schwartz1, Axel Strittmatter2, Ingo Vo 3, Gerhard Gottschalk2, Alexander Steinbüchel3, Bärbel Friedrich1 & Botho Bowien41
Humboldt-Universität zu Berlin, Institut für Biologie/Mikrobiologie, Chausseestrae 117, 10115 Berlin, Germany. 2
Georg-August-Universität Göttingen, Laboratorium für Genomanalyse, Grisebachstrae 8, 37077 Göttingen, Germany. 3
Westfälische Wilhelms-Universität Münster, Institut für Molekulare Mikrobiologie und Biotechnologie, Corrensstrae 3, 48149 Münster, Germany. 4
Georg-August-Universität Göttingen, Institut für Mikrobiologie und Genetik, Grisebachstrae 8, 37077 Göttingen, Germany. 5
These authors contributed equally to this work.
Correspondence should be addressed to Bärbel Friedrich baerbel.friedrich@rz.hu-berlin.de The H2-oxidizing lithoautotrophic bacterium Ralstonia eutropha H16 is a metabolically versatile organism capable of subsisting, in the absence of organic growth substrates, on H2 and CO2 as its sole sources of energy and carbon. R. eutropha H16 first attracted biotechnological interest nearly 50 years ago with the realization that the organism's ability to produce and store large amounts of poly[R-(–)-3-hydroxybutyrate] and other polyesters could be harnessed to make biodegradable plastics. Here we report the complete genome sequence of the two chromosomes of R. eutropha H16. Together, chromosome 1 (4,052,032 base pairs (bp)) and chromosome 2 (2,912,490 bp) encode 6,116 putative genes. Analysis of the genome sequence offers the genetic basis for exploiting the biotechnological potential of this organism and provides insights into its remarkable metabolic versatility.
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