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| Editorial | Top |
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NIH under scrutiny p489
doi:10.1038/nbt0504-489
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(58K)
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| News | Top |
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Cautious exuberance after the first quarter pp491 - 492
Ken Howard
doi:10.1038/nbt0504-491
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(225K)
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Bioinformatics attracts big guns pp492 - 493
Peter Mitchell
doi:10.1038/nbt0504-492
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(442K)
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EU enlargement brings biotech opportunities pp493 - 494
Sabine Louët
doi:10.1038/nbt0504-493
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(282K)
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FDA plans to improve and accelerate product reviews p495
Jeffrey L Fox
doi:10.1038/nbt0504-495
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(83K)
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US NIH draft guidelines threaten diagnostics sector p496
Aparna Surendran
doi:10.1038/nbt0504-496
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(83K)
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| In Brief |
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News In Brief pp497 - 500
doi:10.1038/nbt0504-497
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(262K)
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| News Feature |
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EU expansion: enlarged horizons or false dawn? pp501 - 504
Clare Sansom
doi:10.1038/nbt0504-501
Abstract | Full text | PDF
(187K)
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| Opinion and Comment | Top |
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| Correspondence |
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Phage offer a real alternative pp505 - 506
Gary K Schoolnik, William C Summers
& James D Watson
doi:10.1038/nbt0504-505
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(158K)
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Response: Phage offer a real alternative pp506 - 507
Steven Projan
doi:10.1038/nbt0504-506
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(158K)
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Correspondence 1: Drugs in crops p507
David Zaitlin, Orlando D Chambers, Baochun Li, Richard E Mundell
& H Maelor Davies
doi:10.1038/nbt0504-507
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(138K)
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Correspondence 2: Drugs in crops p508
Michael Antoniou
doi:10.1038/nbt0504-508a
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(60K)
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Correspondence 3: Drugs in crops p508
Julius B Kristinsson
doi:10.1038/nbt0504-508b
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(60K)
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| Commentary |
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Science, politics and the President's Council on Bioethics pp509 - 510
Leigh Turner
doi:10.1038/nbt0504-509
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(68K)
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| Investor's Lab |
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Putting biotech risk in its place p511
Tom Jacobs
doi:10.1038/nbt0504-511
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(54K)
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| Feature | Top |
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Structure-aided drug design's next generation pp513 - 519
Karl A Thiel
doi:10.1038/nbt0504-513
Abstract | Full text | PDF
(1,802K)
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| News and Views | Top |
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Next-generation protein drugs pp521 - 522
Ian M Tomlinson
doi:10.1038/nbt0504-521
Abstract | Full text | PDF
(282K)
See also: Research by Binz et al. |
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Overcoming the gridlock in discovery research pp522 - 524
Jonathan Margolis
& Greg D Plowman
doi:10.1038/nbt0504-522
Abstract | Full text | PDF
(136K)
See also: Research by Peterson et al. |
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Genomics taken to the extreme pp524 - 525
Wolfgang Liebl
doi:10.1038/nbt0504-524
Abstract | Full text | PDF
(277K)
See also: Research by Henne et al. |
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Teamwork in phytoremediation pp526 - 527
Bernard R Glick
doi:10.1038/nbt0504-526
Abstract | Full text | PDF
(212K)
See also: Research by Barac et al. |
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| News and Views Feature |
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Putting the rat on the map pp529 - 531
Ismail Kola
doi:10.1038/nbt0504-529
Abstract | Full text | PDF
(227K)
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Research Notes p533
doi:10.1038/nbt0504-533
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(130K)
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| Research | Top |
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| Review |
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Alternative splicing in disease and therapy pp535 - 546
Mariano A Garcia-Blanco, Andrew P Baraniak
& Erika L Lasda
doi:10.1038/nbt964
Abstract | Full text | PDF
(263K)
| Supplementary Information |
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| Articles |
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The genome sequence of the extreme thermophile Thermus thermophilus pp547 - 553
Anke Henne, Holger Brüggemann, Carsten Raasch, Arnim Wiezer, Thomas Hartsch, Heiko Liesegang, Andre Johann, Tanja Lienard, Olivia Gohl, Rosa Martinez-Arias, Carsten Jacobi, Vytaute Starkuviene, Silke Schlenczeck, Silke Dencker, Robert Huber, Hans-Peter Klenk, Wilfried Kramer, Rainer Merkl, Gerhard Gottschalk
& Hans-Joachim Fritz
Published online: 04 April 2004 | doi:10.1038/nbt956
Abstract | Full text | PDF
(1,926K)
| Supplementary Information
See also: News and Views by Liebl |
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The genome sequence of the anaerobic, sulfate-reducing bacterium Desulfovibrio vulgaris Hildenborough pp554 - 559
John F Heidelberg, Rekha Seshadri, Shelley A Haveman, Christopher L Hemme, Ian T Paulsen, James F Kolonay, Jonathan A Eisen, Naomi Ward, Barbara Methe, Lauren M Brinkac, Sean C Daugherty, Robert T Deboy, Robert J Dodson, A Scott Durkin, Ramana Madupu, William C Nelson, Steven A Sullivan, Derrick Fouts, Daniel H Haft, Jeremy Selengut, Jeremy D Peterson, Tanja M Davidsen, Nikhat Zafar, Liwei Zhou, Diana Radune, George Dimitrov, Mark Hance, Kevin Tran, Hoda Khouri, John Gill, Terry R Utterback, Tamara V Feldblyum, Judy D Wall, Gerrit Voordouw
& Claire M Fraser
Published online: 11 April 2004 | doi:10.1038/nbt959
Abstract | Full text | PDF
(169K)
| Supplementary Information |
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Adipose-derived adult stromal cells heal critical-size mouse calvarial defects pp560 - 567
Catherine M Cowan, Yun-Ying Shi, Oliver O Aalami, Yu-Fen Chou, Carina Mari, Romy Thomas, Natalina Quarto, Christopher H Contag, Benjamin Wu
& Michael T Longaker
Published online: 11 April 2004 | doi:10.1038/nbt958
Abstract | Full text | PDF
(1,356K)
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Encoded self-assembling chemical libraries pp568 - 574
Samu Melkko, Jörg Scheuermann, Christoph E Dumelin
& Dario Neri
Published online: 18 April 2004 | doi:10.1038/nbt961
Abstract | Full text | PDF
(543K)
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High-affinity binders selected from designed ankyrin repeat protein libraries pp575 - 582
H Kaspar Binz, Patrick Amstutz, Andreas Kohl, Michael T Stumpp, Christophe Briand, Patrik Forrer, Markus G Grütter
& Andreas Plückthun
Published online: 18 April 2004 | doi:10.1038/nbt962
Abstract | Full text | PDF
(1,556K)
| Supplementary Information
See also: News and Views by Tomlinson |
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Engineered endophytic bacteria improve phytoremediation of water-soluble, volatile, organic pollutants pp583 - 588
Tanja Barac, Safiyh Taghavi, Brigitte Borremans, Ann Provoost, Licy Oeyen, Jan V Colpaert, Jaco Vangronsveld
& Daniel van der Lelie
Published online: 11 April 2004 | doi:10.1038/nbt960
Abstract | Full text | PDF
(277K)
See also: News and Views by Glick |
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| Letters |
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Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide−based retroviral vector pp589 - 594
Andrea L Szymczak, Creg J Workman, Yao Wang, Kate M Vignali, Smaroula Dilioglou, Elio F Vanin
& Dario A A Vignali
Published online: 04 April 2004 | doi:10.1038/nbt957
Abstract | Full text | PDF
(2,186K)
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Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation pp595 - 599
Randall T Peterson, Stanley Y Shaw, Travis A Peterson, David J Milan, Tao P Zhong, Stuart L Schreiber, Calum A MacRae
& Mark C Fishman
Published online: 18 April 2004 | doi:10.1038/nbt963
Abstract | Full text | PDF
(496K)
See also: News and Views by Margolis & Plowman |
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| Retraction |
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Retraction: Fluorobodies combine GFP fluorescence with the binding characteristics of antibodies p601
Ahmet Zeytun, Andreas Jeromin, Bethe A Scalettar, Geoffrey S Waldo
& Andrew RM Bradbury
doi:10.1038/nbt0504-601
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(46K)
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| Resources | Top |
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| Patents |
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Effecting a comprehensive intellectual property strategy using the Madrid Protocol pp603 - 605
William J Simmons
doi:10.1038/nbt0504-603
Abstract | Full text | PDF
(85K)
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Recent patent applications related to molecular cloning p607
doi:10.1038/nbt0504-607
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(34K)
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| People |
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People p609
doi:10.1038/nbt0504-609
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(74K)
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| New on the Market |
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Bioseparation and cloning p611
doi:10.1038/nbt0504-611
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(208K)
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| Computational Biology | Top |
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| Commentary |
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Data standards for 'omic' science pp613 - 614
John Quackenbush
doi:10.1038/nbt0504-613
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(77K)
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| Perspective |
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Microarray reality checks in the context of a complex disease pp615 - 621
George L Gabor Miklos
& Ryszard Maleszka
Published online: 30 April 2004 | doi:10.1038/nbt965
Abstract | Full text | PDF
(142K)
| Supplementary Information |
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| Bioentrepreneur | Top |
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| Bioenews |
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Japanese national universities are now 'incorporated' pp623 - 624
Keiko Kandachi
Published online: 01 April 2004 | doi:10.1038/bioent801
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'Spinning in': a new concept for technology transfer? pp624 - 625
Emma Dorey
Published online: 25 March 2004 | doi:10.1038/bioent800
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University entrepreneur initiatives on the rise pp625 - 626
Ken Howard
Published online: 08 April 2004 | doi:10.1038/bioent803
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Singapore trains its biotech workforce abroad p627
Jen Lin Liu
Published online: 17 March 2004 | doi:10.1038/bioent799
Reprinted with some modification from the Bioentrepreneur web portal (http://www.nature.com/bioent)
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(579K)
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| Building a business |
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Company founders: voices of experience pp629 - 632
Laura DeFrancesco
Published online: 22 March 2004 | doi:10.1038/bioent796
Reprinted with some modification from the Bioentrepreneur web portal (http://www.nature.com/bioent)
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(252K)
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| Naturejobs | Top |
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| Careers and Recruitment |
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International benchmarking of biotech research centers—lessons and perspectives pp633 - 635
Viola Peter
doi:10.1038/nbt0504-633
Abstract | Full text | PDF
(78K)
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