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| This issue focuses on the potential applications of systems biology to biotechnology. Although at this stage, most models of biological systems are rather rudimentary, the proliferation of high-throughput technologies for gathering data on a large scale is spurring efforts to describe and predict the functioning of entire systems applicable to drug discovery, industrial biotechnology and other sectors. |
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| Editorial | Top |
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Focus on Systems Biology
End of the interlude? p1191
doi:10.1038/nbt1004-1191
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| News | Top |
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Electoral campaign delays resolution of biotech issues p1193
Jeffrey L. Fox
doi:10.1038/nbt1019
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(135K)
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Growing pains in AIDS drug development p1194
Stephan Herrera
doi:10.1038/nbt1004-1194
Abstract | Full text | PDF
(230K)
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Inhaled insulin products puff along pp1195 - 1196
Kendall Powell
doi:10.1038/nbt1004-1195
Abstract | Full text | PDF
(190K)
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China moves to reform biotech policies p1197
Hepeng Jia
doi:10.1038/nbt1004-1197
Abstract | Full text | PDF
(206K)
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Genentech discloses safety concerns over Avastin p1198
Mark Ratner
doi:10.1038/nbt1004-1198
Abstract | Full text | PDF
(77K)
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| In Brief |
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News In Brief pp1199 - 1200
doi:10.1038/nbt1004-1199
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Focus on Systems Biology
Profile: Fritjof Capra p1201
Laura DeFrancesco
doi:10.1038/nbt1004-1201
Abstract | Full text | PDF
(102K)
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| Data Page |
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Biotech patenting matures p1202
Stacy Lawrence
doi:10.1038/nbt1004-1202
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(48K)
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| News Feature |
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A taste of the future pp1203 - 1205
Cormac Sheridan
doi:10.1038/nbt1004-1203
Abstract | Full text | PDF
(371K)
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| Opinion and Comment | Top |
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| Correspondence |
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The need for international stem cell agreements p1207
David B Resnik
doi:10.1038/nbt1004-1207a
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(67K)
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Putting Cartagena into practice pp1207 - 1208
Kazuo N Watanabe, Mohammad Taeb
& Haruko Okusu
doi:10.1038/nbt1004-1207b
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(76K)
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Data hoarding is harming proteomics p1209
William Stafford Noble
doi:10.1038/nbt1004-1209a
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(159K)
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Reply to 'Data hoarding is harming proteomics' p1209
doi:10.1038/nbt1004-1209b
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(159K)
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| Commentary |
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Focus on Systems Biology
A partnership between biology and engineering pp1211 - 1214
Roger Brent
doi:10.1038/nbt1004-1211
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(104K)
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Focus on Systems Biology
The impact of systems approaches on biological problems in drug discovery pp1215 - 1217
Leroy Hood
& Roger M Perlmutter
doi:10.1038/nbt1004-1215
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(182K)
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Focus on Systems Biology
Two-dimensional annotation of genomes pp1218 - 1219
Bernhard Palsson
doi:10.1038/nbt1004-1218
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(111K)
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| Investor's Lab |
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More than meets the eyes? p1221
Tom Jacobs
doi:10.1038/nbt1004-1221
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(59K)
| Supplementary Information |
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| Features | Top |
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Focus on Systems Biology
Can complexity be commercialized? pp1223 - 1229
George S Mack
doi:10.1038/nbt1004-1223
Abstract | Full text | PDF
(620K)
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Towards quality assurance and harmonization of genetic testing services in the European Union pp1230 - 1235
Dolores Ibarreta, Robert Elles, Jean-Jacques Cassiman, Emilio Rodriguez-Cerezo
& Elisabeth Dequeker
doi:10.1038/nbt1004-1230
Abstract | Full text | PDF
(576K)
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| News and Views | Top |
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Embryonic stem cells pace the heart pp1237 - 1238
Philippe Menasché
doi:10.1038/nbt1004-1237
Abstract | Full text | PDF
(187K)
See also: Research by Kehat et al. |
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Phasing in iodine for structure determination pp1239 - 1240
Zbigniew Dauter
doi:10.1038/nbt1004-1239
Abstract | Full text | PDF
(174K)
See also: Research by Xie et al. |
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A universal TANGO? pp1240 - 1241
Vijay S Pande
doi:10.1038/nbt1004-1240
Abstract | Full text | PDF
(106K)
See also: Research by Fernandez-Escamilla et al. |
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Climbing the protein ladder pp1242 - 1243
Norman J Dovichi
doi:10.1038/nbt1004-1242
Abstract | Full text | PDF
(87K)
See also: Research by Zhong et al. |
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Engineering sweet targets for magic bullets pp1244 - 1245
Ten Feizi
doi:10.1038/nbt1004-1244
Abstract | Full text | PDF
(156K)
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Research Highlights p1247
doi:10.1038/nbt1004-1247
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(145K)
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| Historical Perspective | Top |
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Focus on Systems Biology
The evolution of molecular biology into systems biology pp1249 - 1252
Hans V Westerhoff
& Bernhard O Palsson
Published online: 06 October 2004 | doi:10.1038/nbt1020
Abstract | Full text | PDF
(110K)
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| Research | Top |
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| Perspective |
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Focus on Systems Biology
Systems biology in drug discovery pp1253 - 1259
Eugene C Butcher, Ellen L Berg
& Eric J Kunkel
Published online: 06 October 2004 | doi:10.1038/nbt1017
Abstract | Full text | PDF
(438K)
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| Reviews |
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Focus on Systems Biology
Exploiting biological complexity for strain improvement through systems biology pp1261 - 1267
Gregory Stephanopoulos, Hal Alper
& Joel Moxley
Published online: 06 October 2004 | doi:10.1038/nbt1016
Abstract | Full text | PDF
(511K)
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Focus on Systems Biology
The challenges of modeling mammalian biocomplexity pp1268 - 1274
Jeremy K Nicholson, Elaine Holmes, John C Lindon
& Ian D Wilson
Published online: 06 October 2004 | doi:10.1038/nbt1015
Abstract | Full text | PDF
(464K)
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| Articles |
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The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens pp1275 - 1281
Soon Ho Hong, Jin Sik Kim, Sang Yup Lee, Yong Ho In, Sun Shim Choi, Jeong-Keun Rih, Chang Hoon Kim, Haeyoung Jeong, Cheol Goo Hur
& Jae Jong Kim
Published online: 19 September 2004 | doi:10.1038/nbt1010
Abstract | Full text | PDF
(453K)
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Electromechanical integration of cardiomyocytes derived from human embryonic stem cells pp1282 - 1289
Izhak Kehat, Leonid Khimovich, Oren Caspi, Amira Gepstein, Rona Shofti, Gil Arbel, Irit Huber, Jonathan Satin, Joseph Itskovitz-Eldor
& Lior Gepstein
Published online: 26 September 2004 | doi:10.1038/nbt1014
Abstract | Full text | PDF
(1,031K)
| Supplementary Information
See also: News and Views by Menasché |
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| Letters |
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Protein sequencing by mass analysis of polypeptide ladders after controlled protein hydrolysis pp1291 - 1296
Hongying Zhong, Ying Zhang, Zhihui Wen
& Liang Li
Published online: 07 September 2004 | doi:10.1038/nbt1011
Abstract | Full text | PDF
(448K)
| Supplementary Information
See also: News and Views by Dovichi |
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The site-specific incorporation of p-iodo-L-phenylalanine into proteins for structure determination pp1297 - 1301
Jianming Xie, Lei Wang, Ning Wu, Ansgar Brock, Glen Spraggon
& Peter G Schultz
Published online: 19 September 2004 | doi:10.1038/nbt1013
Abstract | Full text | PDF
(303K)
See also: News and Views by Dauter |
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Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins pp1302 - 1306
Ana-Maria Fernandez-Escamilla, Frederic Rousseau, Joost Schymkowitz
& Luis Serrano
Published online: 12 September 2004 | doi:10.1038/nbt1012
Abstract | Full text | PDF
(230K)
| Supplementary Information
See also: News and Views by Pande |
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| Resources | Top |
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| Patents |
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The level of disclosure necessary for patent protection of genetic innovations pp1307 - 1308
Richard J Berman
& Amy EL Schoenhard
doi:10.1038/nbt1004-1307
Abstract | Full text | PDF
(71K)
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Patents p1309
doi:10.1038/nbt1004-1309
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(34K)
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| People |
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People p1311
doi:10.1038/nbt1004-1311
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(81K)
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| New on the Market |
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Expression systems and Imaging & microscopy p1313
doi:10.1038/nbt1004-1313
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(283K)
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| Computational Biology | Top |
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| Primer |
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What is a hidden Markov model? pp1315 - 1316
Sean R Eddy
doi:10.1038/nbt1004-1315
Abstract | Full text | PDF
(184K)
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| Analysis |
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Ten thousand interactions for the molecular biologist pp1317 - 1321
Patrick Aloy
& Robert B Russell
Published online: 06 October 2004 | doi:10.1038/nbt1018
Abstract | Full text | PDF
(465K)
| Supplementary Information |
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| Bioentrepreneur | Top |
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| Bioenews |
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Swiss patent proposal prompts criticism p1323
Jane Burgermeister
Published online: 02 September 2004 | doi:10.1038/bioent827
Reprinted with some modification from the Bioentrepreneur web portal (http://www.nature.com/bioent)
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| Building a business |
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What every CFO should know about equipment financing pp1325 - 1326
J Alden Philbrick
Published online: 23 August 2004 | doi:10.1038/bioent821
Reprinted with some modification from the Bioentrepreneur web portal (http://www.nature.com/bioent)
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(69K)
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| Naturejobs | Top |
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| Careers and Recruitment |
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Changing talent needs to realize biotech products p1327
Mary Ann Rafferty
doi:10.1038/nbt1004-1327
Abstract | Full text | PDF
(51K)
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