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It is obvious that these constraints are entirely dependent on a set of financial assumptions relating to costs, sales and discount rates for R&D expenditures. If these assumptions are modified, if for instance the discount rates after launch are lowered from 14% to 8% or if only out of pocket expenses are taken into account and opportunity costs altogether neglected, the picture brightens considerably. Eventually, such changes may have to be made.
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Drews, J., Ryser, S. Drug Development: The role of innovation in drug development. Nat Biotechnol 15, 1318–1319 (1997). https://doi.org/10.1038/nbt1297-1318
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DOI: https://doi.org/10.1038/nbt1297-1318