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scDamID&T combines DNA adenine methyltransferase-based labeling of protein–DNA contact sites with transcriptome sequencing to analyze regulatory programs in single cells.
Selective killing of bacteria in a mixed population is enabled by engineering an antimicrobial that is toxic only in pathogens harboring specific genetic elements.
Unbiased detection of off-target editing by adenine base editors in vitro uncovers differences in the specificity patterns of adenine and cytosine base editors, and of unmodified Cas9.
A new method using mild chemical reactions and enzymatic oxidation allows nondestructive sequencing of 5-methylcytosine and 5-hydroxymethylcytosine with base-level resolution.
The treasure trove of disease resistance genes present in wild relatives of domesticated crops is rapidly discovered using association genetics and enrichment sequencing.
Hybrids can be self-pollinated to produce true-breeding progeny through seeds by simultaneous genome editing of four endogenous genes in a rice F1 hybrid variety.