Volume 581 Issue 7809, 28 May 2020

Human resource

In this week’s issue, four papers provide in-depth insights gleaned from the Genome Aggregation Database (gnomAD). A successor to 2016’s ExAC database, which held the exomes of 60,706 individuals, gnomAD aggregates 125,748 exomes and 15,708 whole-genome sequences. This increase in size and scope has allowed the gnomAD Consortium to catalogue not only single nucleotide variants between individuals but also more complex structural variants, made up of 50 or more nucleotides. In the main paper, Konrad Karczewski and colleagues review the database and explore variants that can inactivate protein-coding genes. In a second paper, Beryl Cummings and co-workers show that RNA expression data can be used to guide variant interpretation. In another paper, Eric Minikel and colleagues probe how the gnomAD data might help to identify genetic targets for drugs. And in the fourth paper, Ryan Collins and co-workers set out a catalogue of 433,371 structural variants and analyse them for their influence on physiological traits.

Cover image: Sigrid Knemeyer and Hang Yu Lin, SciStories LLC.

This Week

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  • Articles

  • Article |

    The baryon density determined along the lines of sight to localized fast radio bursts is consistent with that determined from the cosmic microwave background and required by Big Bang nucleosynthesis.

    • J.-P. Macquart
    • , J. X. Prochaska
    • , M. McQuinn
    • , K. W. Bannister
    • , S. Bhandari
    • , C. K. Day
    • , A. T. Deller
    • , R. D. Ekers
    • , C. W. James
    • , L. Marnoch
    • , S. Osłowski
    • , C. Phillips
    • , S. D. Ryder
    • , D. R. Scott
    • , R. M. Shannon
    •  & N. Tejos
  • Article | | Open Access

    Measurements of low-energy electronic states of radium monofluoride validate predictions of the use of this short-lived radioactive molecule in exploring fundamental physics and provide evidence of its suitability for laser cooling.

    • R. F. Garcia Ruiz
    • , R. Berger
    • , J. Billowes
    • , C. L. Binnersley
    • , M. L. Bissell
    • , A. A. Breier
    • , A. J. Brinson
    • , K. Chrysalidis
    • , T. E. Cocolios
    • , B. S. Cooper
    • , K. T. Flanagan
    • , T. F. Giesen
    • , R. P. de Groote
    • , S. Franchoo
    • , F. P. Gustafsson
    • , T. A. Isaev
    • , Á. Koszorús
    • , G. Neyens
    • , H. A. Perrett
    • , C. M. Ricketts
    • , S. Rothe
    • , L. Schweikhard
    • , A. R. Vernon
    • , K. D. A. Wendt
    • , F. Wienholtz
    • , S. G. Wilkins
    •  & X. F. Yang
  • Article |

    A thermo-assisted spin-coating process followed by packaging is used to fabricate sodium films that are stable for several months, enabling the realization of plasmonic devices with state-of-the-art performance at near-infrared wavelengths.

    • Yang Wang
    • , Jianyu Yu
    • , Yi-Fei Mao
    • , Ji Chen
    • , Suo Wang
    • , Hua-Zhou Chen
    • , Yi Zhang
    • , Si-Yi Wang
    • , Xinjie Chen
    • , Tao Li
    • , Lin Zhou
    • , Ren-Min Ma
    • , Shining Zhu
    • , Wenshan Cai
    •  & Jia Zhu
  • Article |

    Large-area single-crystal high-index copper and nickel foils with several types of facet are fabricated using mild pre-oxidation of the metal foil surface followed by annealing in a reducing atmosphere.

    • Muhong Wu
    • , Zhibin Zhang
    • , Xiaozhi Xu
    • , Zhihong Zhang
    • , Yunrui Duan
    • , Jichen Dong
    • , Ruixi Qiao
    • , Sifan You
    • , Li Wang
    • , Jiajie Qi
    • , Dingxin Zou
    • , Nianze Shang
    • , Yubo Yang
    • , Hui Li
    • , Lan Zhu
    • , Junliang Sun
    • , Haijun Yu
    • , Peng Gao
    • , Xuedong Bai
    • , Ying Jiang
    • , Zhu-Jun Wang
    • , Feng Ding
    • , Dapeng Yu
    • , Enge Wang
    •  & Kaihui Liu
  • Article |

    Water splitting with an internal quantum efficiency of almost unity is achieved using a modified semiconductor photocatalyst that selectively promotes the hydrogen and oxygen evolution reactions on separate crystal facets.

    • Tsuyoshi Takata
    • , Junzhe Jiang
    • , Yoshihisa Sakata
    • , Mamiko Nakabayashi
    • , Naoya Shibata
    • , Vikas Nandal
    • , Kazuhiko Seki
    • , Takashi Hisatomi
    •  & Kazunari Domen
  • Article |

    The synthesis of tertiary amines is achieved through a carbonyl alkylative amination reaction facilitated by visible light, in which an aldehyde and an amine condense to form an iminium ion that subsequently reacts with alkyl radical.

    • Roopender Kumar
    • , Nils J. Flodén
    • , William G. Whitehurst
    •  & Matthew J. Gaunt
  • Article |

    Adalatherium hui, a newly discovered gondwanatherian mammal from Madagascar dated to near the end of the Cretaceous period, shows features consistent with a long evolutionary trajectory of isolation in an insular environment.

    • David W. Krause
    • , Simone Hoffmann
    • , Yaoming Hu
    • , John R. Wible
    • , Guillermo W. Rougier
    • , E. Christopher Kirk
    • , Joseph R. Groenke
    • , Raymond R. Rogers
    • , James B. Rossie
    • , Julia A. Schultz
    • , Alistair R. Evans
    • , Wighart von Koenigswald
    •  & Lydia J. Rahantarisoa
  • Article |

    Odorant-dependent sniff responses predicted the long-term survival rates of patients with severe brain injury, and discriminated between individuals who were unresponsive and in minimally conscious states.

    • Anat Arzi
    • , Liron Rozenkrantz
    • , Lior Gorodisky
    • , Danit Rozenkrantz
    • , Yael Holtzman
    • , Aharon Ravia
    • , Tristan A. Bekinschtein
    • , Tatyana Galperin
    • , Ben-Zion Krimchansky
    • , Gal Cohen
    • , Anna Oksamitni
    • , Elena Aidinoff
    • , Yaron Sacher
    •  & Noam Sobel
  • The Genome Aggregation Database (gnomAD)

  • Article | | Open Access

    A catalogue of predicted loss-of-function variants in 125,748 whole-exome and 15,708 whole-genome sequencing datasets from the Genome Aggregation Database (gnomAD) reveals the spectrum of mutational constraints that affect these human protein-coding genes.

    • Konrad J. Karczewski
    • , Laurent C. Francioli
    • , Grace Tiao
    • , Beryl B. Cummings
    • , Jessica Alföldi
    • , Qingbo Wang
    • , Ryan L. Collins
    • , Kristen M. Laricchia
    • , Andrea Ganna
    • , Daniel P. Birnbaum
    • , Laura D. Gauthier
    • , Harrison Brand
    • , Matthew Solomonson
    • , Nicholas A. Watts
    • , Daniel Rhodes
    • , Moriel Singer-Berk
    • , Eleina M. England
    • , Eleanor G. Seaby
    • , Jack A. Kosmicki
    • , Raymond K. Walters
    • , Katherine Tashman
    • , Yossi Farjoun
    • , Eric Banks
    • , Timothy Poterba
    • , Arcturus Wang
    • , Cotton Seed
    • , Nicola Whiffin
    • , Jessica X. Chong
    • , Kaitlin E. Samocha
    • , Emma Pierce-Hoffman
    • , Zachary Zappala
    • , Anne H. O’Donnell-Luria
    • , Eric Vallabh Minikel
    • , Ben Weisburd
    • , Monkol Lek
    • , James S. Ware
    • , Christopher Vittal
    • , Irina M. Armean
    • , Louis Bergelson
    • , Kristian Cibulskis
    • , Kristen M. Connolly
    • , Miguel Covarrubias
    • , Stacey Donnelly
    • , Steven Ferriera
    • , Stacey Gabriel
    • , Jeff Gentry
    • , Namrata Gupta
    • , Thibault Jeandet
    • , Diane Kaplan
    • , Christopher Llanwarne
    • , Ruchi Munshi
    • , Sam Novod
    • , Nikelle Petrillo
    • , David Roazen
    • , Valentin Ruano-Rubio
    • , Andrea Saltzman
    • , Molly Schleicher
    • , Jose Soto
    • , Kathleen Tibbetts
    • , Charlotte Tolonen
    • , Gordon Wade
    • , Michael E. Talkowski
    • , Carlos A. Aguilar Salinas
    • , Tariq Ahmad
    • , Christine M. Albert
    • , Diego Ardissino
    • , Gil Atzmon
    • , John Barnard
    • , Laurent Beaugerie
    • , Emelia J. Benjamin
    • , Michael Boehnke
    • , Lori L. Bonnycastle
    • , Erwin P. Bottinger
    • , Donald W. Bowden
    • , Matthew J. Bown
    • , John C. Chambers
    • , Juliana C. Chan
    • , Daniel Chasman
    • , Judy Cho
    • , Mina K. Chung
    • , Bruce Cohen
    • , Adolfo Correa
    • , Dana Dabelea
    • , Mark J. Daly
    • , Dawood Darbar
    • , Ravindranath Duggirala
    • , Josée Dupuis
    • , Patrick T. Ellinor
    • , Roberto Elosua
    • , Jeanette Erdmann
    • , Tõnu Esko
    • , Martti Färkkilä
    • , Jose Florez
    • , Andre Franke
    • , Gad Getz
    • , Benjamin Glaser
    • , Stephen J. Glatt
    • , David Goldstein
    • , Clicerio Gonzalez
    • , Leif Groop
    • , Christopher Haiman
    • , Craig Hanis
    • , Matthew Harms
    • , Mikko Hiltunen
    • , Matti M. Holi
    • , Christina M. Hultman
    • , Mikko Kallela
    • , Jaakko Kaprio
    • , Sekar Kathiresan
    • , Bong-Jo Kim
    • , Young Jin Kim
    • , George Kirov
    • , Jaspal Kooner
    • , Seppo Koskinen
    • , Harlan M. Krumholz
    • , Subra Kugathasan
    • , Soo Heon Kwak
    • , Markku Laakso
    • , Terho Lehtimäki
    • , Ruth J. F. Loos
    • , Steven A. Lubitz
    • , Ronald C. W. Ma
    • , Daniel G. MacArthur
    • , Jaume Marrugat
    • , Kari M. Mattila
    • , Steven McCarroll
    • , Mark I. McCarthy
    • , Dermot McGovern
    • , Ruth McPherson
    • , James B. Meigs
    • , Olle Melander
    • , Andres Metspalu
    • , Benjamin M. Neale
    • , Peter M. Nilsson
    • , Michael C. O’Donovan
    • , Dost Ongur
    • , Lorena Orozco
    • , Michael J. Owen
    • , Colin N. A. Palmer
    • , Aarno Palotie
    • , Kyong Soo Park
    • , Carlos Pato
    • , Ann E. Pulver
    • , Nazneen Rahman
    • , Anne M. Remes
    • , John D. Rioux
    • , Samuli Ripatti
    • , Dan M. Roden
    • , Danish Saleheen
    • , Veikko Salomaa
    • , Nilesh J. Samani
    • , Jeremiah Scharf
    • , Heribert Schunkert
    • , Moore B. Shoemaker
    • , Pamela Sklar
    • , Hilkka Soininen
    • , Harry Sokol
    • , Tim Spector
    • , Patrick F. Sullivan
    • , Jaana Suvisaari
    • , E. Shyong Tai
    • , Yik Ying Teo
    • , Tuomi Tiinamaija
    • , Ming Tsuang
    • , Dan Turner
    • , Teresa Tusie-Luna
    • , Erkki Vartiainen
    • , James S. Ware
    • , Hugh Watkins
    • , Rinse K. Weersma
    • , Maija Wessman
    • , James G. Wilson
    • , Ramnik J. Xavier
    • , Benjamin M. Neale
    • , Mark J. Daly
    •  & Daniel G. MacArthur

    Special:

  • Article | | Open Access

    A large empirical assessment of sequence-resolved structural variants from 14,891 genomes across diverse global populations in the Genome Aggregation Database (gnomAD) provides a reference map for disease-association studies, population genetics, and diagnostic screening.

    • Ryan L. Collins
    • , Harrison Brand
    • , Konrad J. Karczewski
    • , Xuefang Zhao
    • , Jessica Alföldi
    • , Laurent C. Francioli
    • , Amit V. Khera
    • , Chelsea Lowther
    • , Laura D. Gauthier
    • , Harold Wang
    • , Nicholas A. Watts
    • , Matthew Solomonson
    • , Anne O’Donnell-Luria
    • , Alexander Baumann
    • , Ruchi Munshi
    • , Mark Walker
    • , Christopher W. Whelan
    • , Yongqing Huang
    • , Ted Brookings
    • , Ted Sharpe
    • , Matthew R. Stone
    • , Elise Valkanas
    • , Jack Fu
    • , Grace Tiao
    • , Kristen M. Laricchia
    • , Valentin Ruano-Rubio
    • , Christine Stevens
    • , Namrata Gupta
    • , Caroline Cusick
    • , Lauren Margolin
    • , Jessica Alföldi
    • , Irina M. Armean
    • , Eric Banks
    • , Louis Bergelson
    • , Kristian Cibulskis
    • , Ryan L. Collins
    • , Kristen M. Connolly
    • , Miguel Covarrubias
    • , Beryl Cummings
    • , Mark J. Daly
    • , Stacey Donnelly
    • , Yossi Farjoun
    • , Steven Ferriera
    • , Laurent Francioli
    • , Stacey Gabriel
    • , Laura D. Gauthier
    • , Jeff Gentry
    • , Namrata Gupta
    • , Thibault Jeandet
    • , Diane Kaplan
    • , Konrad J. Karczewski
    • , Kristen M. Laricchia
    • , Christopher Llanwarne
    • , Eric V. Minikel
    • , Ruchi Munshi
    • , Benjamin M. Neale
    • , Sam Novod
    • , Anne H. O’Donnell-Luria
    • , Nikelle Petrillo
    • , Timothy Poterba
    • , David Roazen
    • , Valentin Ruano-Rubio
    • , Andrea Saltzman
    • , Kaitlin E. Samocha
    • , Molly Schleicher
    • , Cotton Seed
    • , Matthew Solomonson
    • , Jose Soto
    • , Grace Tiao
    • , Kathleen Tibbetts
    • , Charlotte Tolonen
    • , Christopher Vittal
    • , Gordon Wade
    • , Arcturus Wang
    • , Qingbo Wang
    • , James S. Ware
    • , Nicholas A. Watts
    • , Ben Weisburd
    • , Nicola Whiffin
    • , Carlos A. Aguilar Salinas
    • , Tariq Ahmad
    • , Christine M. Albert
    • , Diego Ardissino
    • , Gil Atzmon
    • , John Barnard
    • , Laurent Beaugerie
    • , Emelia J. Benjamin
    • , Michael Boehnke
    • , Lori L. Bonnycastle
    • , Erwin P. Bottinger
    • , Donald W. Bowden
    • , Matthew J. Bown
    • , John C. Chambers
    • , Juliana C. Chan
    • , Daniel Chasman
    • , Judy Cho
    • , Mina K. Chung
    • , Bruce Cohen
    • , Adolfo Correa
    • , Dana Dabelea
    • , Mark J. Daly
    • , Dawood Darbar
    • , Ravindranath Duggirala
    • , Josée Dupuis
    • , Patrick T. Ellinor
    • , Roberto Elosua
    • , Jeanette Erdmann
    • , Tõnu Esko
    • , Martti Färkkilä
    • , Jose Florez
    • , Andre Franke
    • , Gad Getz
    • , Benjamin Glaser
    • , Stephen J. Glatt
    • , David Goldstein
    • , Clicerio Gonzalez
    • , Leif Groop
    • , Christopher Haiman
    • , Craig Hanis
    • , Matthew Harms
    • , Mikko Hiltunen
    • , Matti M. Holi
    • , Christina M. Hultman
    • , Mikko Kallela
    • , Jaakko Kaprio
    • , Sekar Kathiresan
    • , Bong-Jo Kim
    • , Young Jin Kim
    • , George Kirov
    • , Jaspal Kooner
    • , Seppo Koskinen
    • , Harlan M. Krumholz
    • , Subra Kugathasan
    • , Soo Heon Kwak
    • , Markku Laakso
    • , Terho Lehtimäki
    • , Ruth J. F. Loos
    • , Steven A. Lubitz
    • , Ronald C. W. Ma
    • , Daniel G. MacArthur
    • , Jaume Marrugat
    • , Kari M. Mattila
    • , Steven McCarroll
    • , Mark I. McCarthy
    • , Dermot McGovern
    • , Ruth McPherson
    • , James B. Meigs
    • , Olle Melander
    • , Andres Metspalu
    • , Benjamin M. Neale
    • , Peter M. Nilsson
    • , Michael C. O’Donovan
    • , Dost Ongur
    • , Lorena Orozco
    • , Michael J. Owen
    • , Colin N. A. Palmer
    • , Aarno Palotie
    • , Kyong Soo Park
    • , Carlos Pato
    • , Ann E. Pulver
    • , Nazneen Rahman
    • , Anne M. Remes
    • , John D. Rioux
    • , Samuli Ripatti
    • , Dan M. Roden
    • , Danish Saleheen
    • , Veikko Salomaa
    • , Nilesh J. Samani
    • , Jeremiah Scharf
    • , Heribert Schunkert
    • , Moore B. Shoemaker
    • , Pamela Sklar
    • , Hilkka Soininen
    • , Harry Sokol
    • , Tim Spector
    • , Patrick F. Sullivan
    • , Jaana Suvisaari
    • , E. Shyong Tai
    • , Yik Ying Teo
    • , Tuomi Tiinamaija
    • , Ming Tsuang
    • , Dan Turner
    • , Teresa Tusie-Luna
    • , Erkki Vartiainen
    • , James S. Ware
    • , Hugh Watkins
    • , Rinse K. Weersma
    • , Maija Wessman
    • , James G. Wilson
    • , Ramnik J. Xavier
    • , Kent D. Taylor
    • , Henry J. Lin
    • , Stephen S. Rich
    • , Wendy S. Post
    • , Yii-Der Ida Chen
    • , Jerome I. Rotter
    • , Chad Nusbaum
    • , Anthony Philippakis
    • , Eric Lander
    • , Stacey Gabriel
    • , Benjamin M. Neale
    • , Sekar Kathiresan
    • , Mark J. Daly
    • , Eric Banks
    • , Daniel G. MacArthur
    •  & Michael E. Talkowski

    Special:

  • Article | | Open Access

    A novel variant annotation metric that quantifies the level of expression of genetic variants across tissues is validated in the Genome Aggregation Database (gnomAD) and is shown to improve rare variant interpretation.

    • Beryl B. Cummings
    • , Konrad J. Karczewski
    • , Jack A. Kosmicki
    • , Eleanor G. Seaby
    • , Nicholas A. Watts
    • , Moriel Singer-Berk
    • , Jonathan M. Mudge
    • , Juha Karjalainen
    • , F. Kyle Satterstrom
    • , Anne H. O’Donnell-Luria
    • , Timothy Poterba
    • , Cotton Seed
    • , Matthew Solomonson
    • , Jessica Alföldi
    • , Jessica Alföldi
    • , Irina M. Armean
    • , Eric Banks
    • , Louis Bergelson
    • , Kristian Cibulskis
    • , Ryan L. Collins
    • , Kristen M. Connolly
    • , Miguel Covarrubias
    • , Beryl B. Cummings
    • , Mark J. Daly
    • , Stacey Donnelly
    • , Yossi Farjoun
    • , Steven Ferriera
    • , Laurent Francioli
    • , Stacey Gabriel
    • , Laura D. Gauthier
    • , Jeff Gentry
    • , Namrata Gupta
    • , Thibault Jeandet
    • , Diane Kaplan
    • , Konrad J. Karczewski
    • , Kristen M. Laricchia
    • , Christopher Llanwarne
    • , Eric V. Minikel
    • , Ruchi Munshi
    • , Benjamin M. Neale
    • , Sam Novod
    • , Anne H. O’Donnell-Luria
    • , Nikelle Petrillo
    • , Timothy Poterba
    • , David Roazen
    • , Valentin Ruano-Rubio
    • , Andrea Saltzman
    • , Kaitlin E. Samocha
    • , Molly Schleicher
    • , Cotton Seed
    • , Matthew Solomonson
    • , Jose Soto
    • , Grace Tiao
    • , Kathleen Tibbetts
    • , Charlotte Tolonen
    • , Christopher Vittal
    • , Gordon Wade
    • , Arcturus Wang
    • , Qingbo Wang
    • , James S. Ware
    • , Nicholas A. Watts
    • , Ben Weisburd
    • , Nicola Whiffin
    • , Carlos A. Aguilar Salinas
    • , Tariq Ahmad
    • , Christine M. Albert
    • , Diego Ardissino
    • , Gil Atzmon
    • , John Barnard
    • , Laurent Beaugerie
    • , Emelia J. Benjamin
    • , Michael Boehnke
    • , Lori L. Bonnycastle
    • , Erwin P. Bottinger
    • , Donald W. Bowden
    • , Matthew J. Bown
    • , John C. Chambers
    • , Juliana C. Chan
    • , Daniel Chasman
    • , Judy Cho
    • , Mina K. Chung
    • , Bruce Cohen
    • , Adolfo Correa
    • , Dana Dabelea
    • , Mark J. Daly
    • , Dawood Darbar
    • , Ravindranath Duggirala
    • , Josée Dupuis
    • , Patrick T. Ellinor
    • , Roberto Elosua
    • , Jeanette Erdmann
    • , Tõnu Esko
    • , Martti Färkkilä
    • , Jose Florez
    • , Andre Franke
    • , Gad Getz
    • , Benjamin Glaser
    • , Stephen J. Glatt
    • , David Goldstein
    • , Clicerio Gonzalez
    • , Leif Groop
    • , Christopher Haiman
    • , Craig Hanis
    • , Matthew Harms
    • , Mikko Hiltunen
    • , Matti M. Holi
    • , Christina M. Hultman
    • , Mikko Kallela
    • , Jaakko Kaprio
    • , Sekar Kathiresan
    • , Bong-Jo Kim
    • , Young Jin Kim
    • , George Kirov
    • , Jaspal Kooner
    • , Seppo Koskinen
    • , Harlan M. Krumholz
    • , Subra Kugathasan
    • , Soo Heon Kwak
    • , Markku Laakso
    • , Terho Lehtimäki
    • , Ruth J. F. Loos
    • , Steven A. Lubitz
    • , Ronald C. W. Ma
    • , Daniel G. MacArthur
    • , Jaume Marrugat
    • , Kari M. Mattila
    • , Steven McCarroll
    • , Mark I. McCarthy
    • , Dermot McGovern
    • , Ruth McPherson
    • , James B. Meigs
    • , Olle Melander
    • , Andres Metspalu
    • , Benjamin M. Neale
    • , Peter M. Nilsson
    • , Michael C. O’Donovan
    • , Dost Ongur
    • , Lorena Orozco
    • , Michael J. Owen
    • , Colin N. A. Palmer
    • , Aarno Palotie
    • , Kyong Soo Park
    • , Carlos Pato
    • , Ann E. Pulver
    • , Nazneen Rahman
    • , Anne M. Remes
    • , John D. Rioux
    • , Samuli Ripatti
    • , Dan M. Roden
    • , Danish Saleheen
    • , Veikko Salomaa
    • , Nilesh J. Samani
    • , Jeremiah Scharf
    • , Heribert Schunkert
    • , Moore B. Shoemaker
    • , Pamela Sklar
    • , Hilkka Soininen
    • , Harry Sokol
    • , Tim Spector
    • , Patrick F. Sullivan
    • , Jaana Suvisaari
    • , E. Shyong Tai
    • , Yik Ying Teo
    • , Tuomi Tiinamaija
    • , Ming Tsuang
    • , Dan Turner
    • , Teresa Tusie-Luna
    • , Erkki Vartiainen
    • , James S. Ware
    • , Hugh Watkins
    • , Rinse K. Weersma
    • , Maija Wessman
    • , James G. Wilson
    • , Ramnik J. Xavier
    • , Mark J. Daly
    •  & Daniel G. MacArthur

    Special:

  • Analysis | | Open Access

    Analysis of predicted loss-of-function variants from 125,748 human exomes and 15,708 whole genomes in the Genome Aggregation Database (gnomAD) provides a roadmap for human ‘knockout’ studies and a guide for future research into disease biology and drug-target selection.

    • Eric Vallabh Minikel
    • , Konrad J. Karczewski
    • , Hilary C. Martin
    • , Beryl B. Cummings
    • , Nicola Whiffin
    • , Daniel Rhodes
    • , Jessica Alföldi
    • , Richard C. Trembath
    • , David A. van Heel
    • , Mark J. Daly
    • , Jessica Alföldi
    • , Irina M. Armean
    • , Eric Banks
    • , Louis Bergelson
    • , Kristian Cibulskis
    • , Ryan L. Collins
    • , Kristen M. Connolly
    • , Miguel Covarrubias
    • , Beryl B. Cummings
    • , Mark J. Daly
    • , Stacey Donnelly
    • , Yossi Farjoun
    • , Steven Ferriera
    • , Laurent Francioli
    • , Stacey Gabriel
    • , Laura D. Gauthier
    • , Jeff Gentry
    • , Namrata Gupta
    • , Thibault Jeandet
    • , Diane Kaplan
    • , Konrad J. Karczewski
    • , Kristen M. Laricchia
    • , Christopher Llanwarne
    • , Eric V. Minikel
    • , Ruchi Munshi
    • , Benjamin M. Neale
    • , Sam Novod
    • , Anne H. O’Donnell-Luria
    • , Nikelle Petrillo
    • , Timothy Poterba
    • , David Roazen
    • , Valentin Ruano-Rubio
    • , Andrea Saltzman
    • , Kaitlin E. Samocha
    • , Molly Schleicher
    • , Cotton Seed
    • , Matthew Solomonson
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    • , James G. Wilson
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    • , Stuart L. Schreiber
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Nature Index

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    2020 South Korea

    A concerted government push to make South Korea an innovation leader, backed by strong investment and systemic reform, has brought rapid and long-lasting results.

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