11 May 2008

Article

PML targeting eradicates quiescent leukaemia-initiating cells

Keisuke Ito, Rosa Bernardi, Alessandro Morotti, Sahoko Matsuoka, Giuseppe Saglio, Yasuo Ikeda, Jacalyn Rosenblatt, David E. Avigan, Julie Teruya-Feldstein & Pier Paolo Pandolfi

doi:10.1038/nature07016

Abstract | Full Text | PDF (1,317K) | Supplementary information

Letters

Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia

Keizo Kanasaki, Kristin Palmsten, Hikaru Sugimoto, Shakil Ahmad, Yuki Hamano, Liang Xie, Samuel Parry, Hellmut G. Augustin, Vincent H. Gattone, Judah Folkman, Jerome F. Strauss & Raghu Kalluri

doi:10.1038/nature06951

First paragraph | Full Text | PDF (748K) | Supplementary information

Ultrasonic frogs show hyperacute phonotaxis to female courtship calls

Jun-Xian Shen, Albert S. Feng, Zhi-Min Xu, Zu-Lin Yu, Victoria S. Arch, Xin-Jian Yu & Peter M. Narins

doi:10.1038/nature06719

First paragraph | Full Text | PDF (399K) | Supplementary information

Rapid strengthening of thalamo-amygdala synapses mediates cue–reward learning

Kay M. Tye, Garret D. Stuber, Bram de Ridder, Antonello Bonci & Patricia H. Janak

doi:10.1038/nature06963

First paragraph | Full Text | PDF (976K) | Supplementary information

IL-21 and TGF- are required for differentiation of human T_H17 cells

Li Yang, David E. Anderson, Clare Baecher-Allan, William D. Hastings, Estelle Bettelli, Mohamed Oukka, Vijay K. Kuchroo & David A. Hafler

doi:10.1038/nature07021

First paragraph | Full Text | PDF (270K) | Supplementary information

07 May 2008

Article

The branching programme of mouse lung development

Ross J. Metzger, Ophir D. Klein, Gail R. Martin & Mark A. Krasnow

doi:10.1038/nature07005

Abstract | Full Text | PDF (1,421K) | Supplementary information

Letters

An endogenous small interfering RNA pathway in Drosophila

Benjamin Czech, Colin D. Malone, Rui Zhou, Alexander Stark, Catherine Schlingeheyde, Monica Dus, Norbert Perrimon, Manolis Kellis, James A. Wohlschlegel, Ravi Sachidanandam, Gregory J. Hannon & Julius Brennecke

doi:10.1038/nature07007

First paragraph | Full Text | PDF (565K) | Supplementary information

Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient

Brian G. Fuller, Michael A. Lampson, Emily A. Foley, Sara Rosasco-Nitcher, Kim V. Le, Page Tobelmann, David L. Brautigan, P. Todd Stukenberg & Tarun M. Kapoor

doi:10.1038/nature06923

First paragraph | Full Text | PDF (874K) | Supplementary information

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

Lars Guelen, Ludo Pagie, Emilie Brasset, Wouter Meuleman, Marius B. Faza, Wendy Talhout, Bert H. Eussen, Annelies de Klein, Lodewyk Wessels, Wouter de Laat & Bas van Steensel

doi:10.1038/nature06947

First paragraph | Full Text | PDF (1,299K) | Supplementary information

Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

Wei Guo, Joseph L. Lasky, Chun-Ju Chang, Sherly Mosessian, Xiaoman Lewis, Yun Xiao, Jennifer E. Yeh, James Y. Chen, M. Luisa Iruela-Arispe, Marileila Varella-Garcia & Hong Wu

doi:10.1038/nature06933

First paragraph | Full Text | PDF (793K) | Supplementary information

Drosophila endogenous small RNAs bind to Argonaute 2 in somatic cells

Yoshinori Kawamura, Kuniaki Saito, Taishin Kin, Yukiteru Ono, Kiyoshi Asai, Takafumi Sunohara, Tomoko N. Okada, Mikiko C. Siomi & Haruhiko Siomi

doi:10.1038/nature06938

First paragraph | Full Text | PDF (748K) | Supplementary information

Cytokinin and auxin interaction in root stem-cell specification during early embryogenesis

Bruno Müller & Jen Sheen

doi:10.1038/nature06943

First paragraph | Full Text | PDF (838K) | Supplementary information

The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs

Katsutomo Okamura, Wei-Jen Chung, J. Graham Ruby, Huili Guo, David P. Bartel & Eric C. Lai

doi:10.1038/nature07015

First paragraph | Full Text | PDF (417K) | Supplementary information

Global control of cell-cycle transcription by coupled CDK and network oscillators

David A. Orlando, Charles Y. Lin, Allister Bernard, Jean Y. Wang, Joshua E. S. Socolar, Edwin S. Iversen, Alexander J. Hartemink & Steven B. Haase

doi:10.1038/nature06955

First paragraph | Full Text | PDF (801K) | Supplementary information

04 May 2008

Letters

Neural substrates of vocalization feedback monitoring in primate auditory cortex

Steven J. Eliades & Xiaoqin Wang

doi:10.1038/nature06910

First paragraph | Full Text | PDF (592K) | Supplementary information

Cladistic analysis of continuous modularized traits provides phylogenetic signals in Homo evolution

Rolando González-José, Ignacio Escapa, Walter A. Neves, Rubén Cúneo & Héctor M. Pucciarelli

doi:10.1038/nature06891

First paragraph | Full Text | PDF (560K) | Supplementary information

Essential role for Nix in autophagic maturation of erythroid cells

Hector Sandoval, Perumal Thiagarajan, Swapan K. Dasgupta, Armin Schumacher, Josef T. Prchal, Min Chen & Jin Wang

doi:10.1038/nature07006

First paragraph | Full Text | PDF (884K) | Supplementary information

Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer

Ryohei Sekido & Robin Lovell-Badge

doi:10.1038/nature06944

First paragraph | Full Text | PDF (535K) | Supplementary information

Dynamics of fat cell turnover in humans

Kirsty L. Spalding, Erik Arner, Pål O. Westermark, Samuel Bernard, Bruce A. Buchholz, Olaf Bergmann, Lennart Blomqvist, Johan Hoffstedt, Erik Näslund, Tom Britton, Hernan Concha, Moustapha Hassan, Mikael Rydén, Jonas Frisén & Peter Arner

doi:10.1038/nature06902

First paragraph | Full Text | PDF (532K) | Supplementary information

30 April 2008

Letters

Angiogenesis selectively requires the p110 isoform of PI3K to control endothelial cell migration

Mariona Graupera, Julie Guillermet-Guibert, Lazaros C. Foukas, Li-Kun Phng, Robert J. Cain, Ashreena Salpekar, Wayne Pearce, Stephen Meek, Jaime Millan, Pedro R. Cutillas, Andrew J. H. Smith, Anne J. Ridley, Christiana Ruhrberg, Holger Gerhardt & Bart Vanhaesebroeck

doi:10.1038/nature06892

First paragraph | Full Text | PDF (993K) | Supplementary information

The Cl^-/H⁺ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes

Austin R. Graves, Patricia K. Curran, Carolyn L. Smith & Joseph A. Mindell

doi:10.1038/nature06907

First paragraph | Full Text | PDF (445K) | Supplementary information

RNA toxicity is a component of ataxin-3 degeneration in Drosophila

Ling-Bo Li, Zhenming Yu, Xiuyin Teng & Nancy M. Bonini

doi:10.1038/nature06909

First paragraph | Full Text | PDF (617K) | Supplementary information

Chemical compass model of avian magnetoreception

Kiminori Maeda, Kevin B. Henbest, Filippo Cintolesi, Ilya Kuprov, Christopher T. Rodgers, Paul A. Liddell, Devens Gust, Christiane R. Timmel & P. J. Hore

doi:10.1038/nature06834

First paragraph | Full Text | PDF (542K) | Supplementary information

Genetic evidence that FGFs have an instructive role in limb proximal–distal patterning

Francesca V. Mariani, Christina P. Ahn & Gail R. Martin

doi:10.1038/nature06876

First paragraph | Full Text | PDF (533K) | Supplementary information

Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation

Robert K. McGinty, Jaehoon Kim, Champak Chatterjee, Robert G. Roeder & Tom W. Muir

doi:10.1038/nature06906

First paragraph | Full Text | PDF (675K) | Supplementary information

Single-stranded DNA-binding protein hSSB1 is critical for genomic stability

Derek J. Richard, Emma Bolderson, Liza Cubeddu, Ross I. M. Wadsworth, Kienan Savage, Girdhar G. Sharma, Matthew L. Nicolette, Sergie Tsvetanov, Michael J. McIlwraith, Raj K. Pandita, Shunichi Takeda, Ronald T. Hay, Jean Gautier, Stephen C. West, Tanya T. Paull, Tej K. Pandita, Malcolm F. White & Kum Kum Khanna

doi:10.1038/nature06883

First paragraph | Full Text | PDF (873K) | Supplementary information

A novel route for ATP acquisition by the remnant mitochondria of Encephalitozoon cuniculi

Anastasios D. Tsaousis, Edmund R. S. Kunji, Alina V. Goldberg, John M. Lucocq, Robert P. Hirt & T. Martin Embley

doi:10.1038/nature06903

First paragraph | Full Text | PDF (789K) | Supplementary information

Rapid cloning of high-affinity human monoclonal antibodies against influenza virus

Jens Wrammert, Kenneth Smith, Joe Miller, William A. Langley, Kenneth Kokko, Christian Larsen, Nai-Ying Zheng, Israel Mays, Lori Garman, Christina Helms, Judith James, Gillian M. Air, J. Donald Capra, Rafi Ahmed & Patrick C. Wilson

doi:10.1038/nature06890

First paragraph | Full Text | PDF (716K) | Supplementary information

3.88 Å structure of cytoplasmic polyhedrosis virus by cryo-electron microscopy

Xuekui Yu, Lei Jin & Z. Hong Zhou

doi:10.1038/nature06893

• PDB code

  • EMD-1508
  • 3CNF

• 3D view

  • EMD-1508
  • 3CNF

First paragraph | Full Text | PDF (1,268K) | Supplementary information

27 April 2008

Letter

HP1- mobilization promotes chromatin changes that initiate the DNA damage response

Nabieh Ayoub, Anand D. Jeyasekharan, Juan A. Bernal & Ashok R. Venkitaraman

doi:10.1038/nature06875

First paragraph | Full Text | PDF (1,170K) | Supplementary information

23 April 2008

Letters

NF-B links innate immunity to the hypoxic response through transcriptional regulation of HIF-1

Jordi Rius, Monica Guma, Christian Schachtrup, Katerina Akassoglou, Annelies S. Zinkernagel, Victor Nizet, Randall S. Johnson, Gabriel G. Haddad & Michael Karin

doi:10.1038/nature06905

First paragraph | Full Text | PDF (469K) | Supplementary information

Superconductivity at 43 K in an iron-based layered compound LaO_1-xF_xFeAs

Hiroki Takahashi, Kazumi Igawa, Kazunobu Arii, Yoichi Kamihara, Masahiro Hirano & Hideo Hosono

doi:10.1038/nature06972

First paragraph | Full Text | PDF (728K)

Human cardiovascular progenitor cells develop from a KDR⁺ embryonic-stem-cell-derived population

Lei Yang, Mark H. Soonpaa, Eric D. Adler, Torsten K. Roepke, Steven J. Kattman, Marion Kennedy, Els Henckaerts, Kristina Bonham, Geoffrey W. Abbott, R. Michael Linden, Loren J. Field & Gordon M. Keller

doi:10.1038/nature06894

First paragraph | Full Text | PDF (1,062K) | Supplementary information

Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling

Jennifer S. Ziegenfuss, Romi Biswas, Michelle A. Avery, Kyoungja Hong, Amy E. Sheehan, Yee-Guide Yeung, E. Richard Stanley & Marc R. Freeman

doi:10.1038/nature06901

First paragraph | Full Text | PDF (740K) | Supplementary information

20 April 2008

Letters

Evolution of metal hyperaccumulation required cis-regulatory changes and triplication of HMA4

Marc Hanikenne, Ina N. Talke, Michael J. Haydon, Christa Lanz, Andrea Nolte, Patrick Motte, Juergen Kroymann, Detlef Weigel & Ute Krämer

doi:10.1038/nature06877

First paragraph | Full Text | PDF (598K) | Supplementary information

Human metabolic phenotype diversity and its association with diet and blood pressure

Elaine Holmes, Ruey Leng Loo, Jeremiah Stamler, Magda Bictash, Ivan K. S. Yap, Queenie Chan, Tim Ebbels, Maria De Iorio, Ian J. Brown, Kirill A. Veselkov, Martha L. Daviglus, Hugo Kesteloot, Hirotsugu Ueshima, Liancheng Zhao, Jeremy K. Nicholson & Paul Elliott

doi:10.1038/nature06882

First paragraph | Full Text | PDF (1,332K) | Supplementary information

16 April 2008

Article

The genomic and epidemiological dynamics of human influenza A virus

Andrew Rambaut, Oliver G. Pybus, Martha I. Nelson, Cecile Viboud, Jeffery K. Taubenberger & Edward C. Holmes

doi:10.1038/nature06945

Abstract | Full Text | PDF (772K) | Supplementary information

Letters

Vascular normalization in Rgs5-deficient tumours promotes immune destruction

Juliana Hamzah, Manfred Jugold, Fabian Kiessling, Paul Rigby, Mitali Manzur, Hugo H. Marti, Tamer Rabie, Sylvia Kaden, Hermann-Josef Gröne, Günter J. Hämmerling, Bernd Arnold & Ruth Ganss

doi:10.1038/nature06868

First paragraph | Full Text | PDF (564K) | Supplementary information

Free choice activates a decision circuit between frontal and parietal cortex

Bijan Pesaran, Matthew J. Nelson & Richard A. Andersen

doi:10.1038/nature06849

First paragraph | Full Text | PDF (649K) | Supplementary information

Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins

Abbhirami Rajagopal, Anita U. Rao, Julio Amigo, Meng Tian, Sanjeev K. Upadhyay, Caitlin Hall, Suji Uhm, M. K. Mathew, Mark D. Fleming, Barry H. Paw, Michael Krause & Iqbal Hamza

doi:10.1038/nature06934

First paragraph | Full Text | PDF (1,353K) | Supplementary information

13 April 2008

Article

Nucleosome organization in the Drosophila genome

Travis N. Mavrich, Cizhong Jiang, Ilya P. Ioshikhes, Xiaoyong Li, Bryan J. Venters, Sara J. Zanton, Lynn P. Tomsho, Ji Qi, Robert L. Glaser, Stephan C. Schuster, David S. Gilmour, Istvan Albert & B. Franklin Pugh

doi:10.1038/nature06929

Abstract | Full Text | PDF (1,640K) | Supplementary information

Letter

Functional genomic screen reveals genes involved in lipid-droplet formation and utilization

Yi Guo, Tobias C. Walther, Meghana Rao, Nico Stuurman, Gohta Goshima, Koji Terayama, Jinny S. Wong, Ronald D. Vale, Peter Walter & Robert V. Farese

doi:10.1038/nature06928

First paragraph | Full Text | PDF (1,220K) | Supplementary information

10 April 2008

Letters

Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes

Oliver H. Tam, Alexei A. Aravin, Paula Stein, Angelique Girard, Elizabeth P. Murchison, Sihem Cheloufi, Emily Hodges, Martin Anger, Ravi Sachidanandam, Richard M. Schultz & Gregory J. Hannon

doi:10.1038/nature06904

First paragraph | Full Text | PDF (464K) | Supplementary information

Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes

Toshiaki Watanabe, Yasushi Totoki, Atsushi Toyoda, Masahiro Kaneda, Satomi Kuramochi-Miyagawa, Yayoi Obata, Hatsune Chiba, Yuji Kohara, Tomohiro Kono, Toru Nakano, M. Azim Surani, Yoshiyuki Sakaki & Hiroyuki Sasaki

doi:10.1038/nature06908

First paragraph | Full Text | PDF (381K) | Supplementary information