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In an information-abundant landscape, people can accurately judge the reputations of others by researching only a fraction of the available information while forgiving some instances of bad behaviour.
Climate warming has increased forest fire sizes, amplifying postfire summer warming, with broadleaf trees mitigating this effect; climate-smart forestry should increase broadleaf tree cover to manage future fire risks.
A combination of palaeoclimate proxies and simulations shows that a common mechanism controls El Niño variation in cold and warm states, which supports expectations of more extreme El Niño occurrence in the future.
A new approach to designing robotic systems that interact closely with people, called human-in-the-loop optimization, can improve human–robot interaction, but many important research questions remain before it can reach its full potential.
Reversible DNA inversions found entirely within genes enable increased coding capacity by encoding multiple versions of a protein in bacteria and archaea.
Transferrin receptor targeting chimeras have been developed that enable targeting of drug resistance in epidermal growth factor receptor-driven lung cancer and reversible control of human primary chimeric antigen receptor T cells, representing a promising new family of bifunctional antibodies for targeted cancer therapy.
By experimentally sampling from sequence spaces larger than 1010 and using thermodynamic models, the genetic structure of at least some proteins can be well described, indicating that protein genetics is simpler than anticipated.
Scaling up and shaping up large language models increased their tendency to provide sensible yet incorrect answers at difficulty levels humans cannot supervise, highlighting the need for a fundamental shift in artificial intelligence design towards reliability.
Single-neuron recordings from intracranial electrodes inserted into human brains for clinical reasons suggest that the temporal structure of human experience is encoded in human hippocampal and entorhinal neurons.
Tree-ring records used to reconstruct the variability of the European jet stream from 1300 to 2004 ce show modulation of extreme regional climate events and extensive impacts on agriculture and human well-being.
The tRNA synthases AARS1 and AARS2 are identified as evolutionarily conserved sensors of intracellular l-lactate to mediate the global lysine lactylome.
The distribution and uptake of siderophores across a meridional section of the eastern Pacific Ocean suggests that iron availability limits microbial metabolism in the upper mesopelagic in several large ocean basins.
The dentary–squamosal contact, traditionally considered to be a typical mammalian feature, evolved more than once and is more evolutionary labile than previously considered.