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Researchers can work long and hard for a permanent academic position, only for their hopes to be dashed. Nature sought advice from three scientists who have experienced the same disappointment.
A genetic screen that expresses single guide RNA libraries targeting host genes in the human cytomegalovirus genome enables identification of host factors and provides insights into their roles during the viral replication cycle.
ETS2—which is associated with inflammatory bowel disease, ankylosing spondylitis, primary sclerosing cholangitis and Takayasu’s arteritis—is a central regulator of human inflammatory macrophages.
MYCT1 is identified as a crucial regulator of cellular properties essential for the stemness of human haematopoietic stem cells, a finding that may help improve successful in vitro expansion of these cells for therapeutics.
The spontaneous formation of magnesium-intercalated gallium nitride superlattices by the interstitial intercalation of two-dimensional magnesium results in considerable compressive strain perpendicular to the layers, leading to enhanced hole transport.
Analysis of some of the main fault zones in California shows that the presence of complex earthquake fault-network geometries results in geometric locking that promotes stick-slip behaviour, whereas simpler geometries lead to smooth fault creep.
A bioresorbable, wireless hydrogel (metagel) sensor, encompassing both biodegradable and stimulus-responsive hydrogels for ultrasonic monitoring of intracranial signals, was implanted into intracranial space with a puncture needle and deformed in response to physiological environmental changes.
Cross-hatch impressions from Ediacaran rocks in China are interpreted as having been left by a crown-group sponge fossil, Helicolocellus cantori gen. et sp. nov., characterized by an organic latticework skeleton.
Oligodendrogenesis is shown to be involved in reward learning, with dopaminergic neuronal activity-regulated myelin plasticity being an important reward circuit modification.
This Perspective identifies common misperceptions regarding the harms of online misinformation, finding that exposure to false and inflammatory content is rare and concentrated among a small minority of people who already have extreme views.
The operando imaging of the early formation stages of covalent organic frameworks with the optical technique interferometric scattering microscopy leads to mechanistic insights, enabling the rational development of a synthesis protocol at room temperature instead of elevated temperatures.