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A genetic screen that expresses single guide RNA libraries targeting host genes in the human cytomegalovirus genome enables identification of host factors and provides insights into their roles during the viral replication cycle.
ETS2—which is associated with inflammatory bowel disease, ankylosing spondylitis, primary sclerosing cholangitis and Takayasu’s arteritis—is a central regulator of human inflammatory macrophages.
MYCT1 is identified as a crucial regulator of cellular properties essential for the stemness of human haematopoietic stem cells, a finding that may help improve successful in vitro expansion of these cells for therapeutics.
The spontaneous formation of magnesium-intercalated gallium nitride superlattices by the interstitial intercalation of two-dimensional magnesium results in considerable compressive strain perpendicular to the layers, leading to enhanced hole transport.
Analysis of some of the main fault zones in California shows that the presence of complex earthquake fault-network geometries results in geometric locking that promotes stick-slip behaviour, whereas simpler geometries lead to smooth fault creep.
A bioresorbable, wireless hydrogel (metagel) sensor, encompassing both biodegradable and stimulus-responsive hydrogels for ultrasonic monitoring of intracranial signals, was implanted into intracranial space with a puncture needle and deformed in response to physiological environmental changes.
Cross-hatch impressions from Ediacaran rocks in China are interpreted as having been left by a crown-group sponge fossil, Helicolocellus cantori gen. et sp. nov., characterized by an organic latticework skeleton.
Oligodendrogenesis is shown to be involved in reward learning, with dopaminergic neuronal activity-regulated myelin plasticity being an important reward circuit modification.
This Perspective identifies common misperceptions regarding the harms of online misinformation, finding that exposure to false and inflammatory content is rare and concentrated among a small minority of people who already have extreme views.
The operando imaging of the early formation stages of covalent organic frameworks with the optical technique interferometric scattering microscopy leads to mechanistic insights, enabling the rational development of a synthesis protocol at room temperature instead of elevated temperatures.
Analyses of histone acetylation in Drosophila wing imaginal discs reveal distinct patterns of acetylation and cellular metabolism that affect gene expression and cell specification.
High-resolution time differences between six Middle Palaeolithic hearths from El Salt Unit x (Spain) obtained through archaeomagnetic and archaeostratigraphic analyses show sometimes decade-long intervals between hearths.
The authors identify naturally occurring senescent glia in aged Drosophila brains and decipher their origin and influence, determining that they can appear in response to neuronal mitochondrial dysfunction and that they promote lipid accumulation, indicating that these cells link key ageing phenomena.
Command-like descending neurons in Drosophila melanogaster recruit additional descending neuronal networks to co-ordinate behaviours that require multiple motor subroutines controlling numerous body parts.
We introduce a self-assembly strategy that uses the interface of an aqueous two-phase system to template and stabilize molecularly thin biomimetic block copolymer bilayers of scalable area that can exceed 10 cm2 without defects.