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Nature 462, 46-47 (5 November 2009) | doi:10.1038/462046a; Published online 4 November 2009

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Genetics: Crossover control in two steps

Yonatan B. Tzur1 & Monica P. Colaiácovo1

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During meiotic cell division, chromosome pairs exchange genetic material in a tightly controlled crossover process. Higher-order chromosome structure may regulate this genetic reshuffling at two distinct stages of meiosis.

Meiosis is a cell-division program that reduces the chromosome complement by half, generating haploid gametes (eggs and sperm) from diploid germ cells. Meiosis also has another important function.

  1. Yonatan B. Tzur and Monica P. Colaiácovo are in the Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
    Email: mcolaiacovo@genetics.med.harvard.edu

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