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Nature 461, 737-739 (8 October 2009) | doi:10.1038/461737a; Published online 7 October 2009

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Vision: Gene therapy in colour

Robert Shapley1

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Replacing a missing gene in adult colour-blind monkeys restores normal colour vision. How the new photoreceptor cells produced by this therapy lead to colour vision is a fascinating question.

Colour blindness is a common genetic disorder (affecting about 5–8% of males, although fewer than 1% of females) in which the absence of a single gene on the X chromosome leads to a specific loss of function. Normal human colour vision relies on three distinct photopigments in the retina's cone photoreceptors.

  1. Robert Shapley is at the Center for Neural Science, New York University, New York 10003, USA.
    Email: shapley@cns.nyu.edu

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