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Nature 461, 47-49 (3 September 2009) | doi:10.1038/461047a; Published online 2 September 2009
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PhD - Helmholtz International Graduate School for Infection Research
- Helmholtz-Zentrum fur Infektionsforschung
- Braunschweig Germany
Junior Research Groups (W1 / W2)
- Cluster of Excellence "Multimodal Computing and Interaction"
- Saarbruecken Germany
Structural biology: A channel with a twist
Valeria Vásquez1 & Eduardo Perozo2
Abstract
Mechanosensitive channels release tension in cell membranes by opening 'pressure relief' pores. The structure of a partially open channel suggests a gating mechanism and delivers an unexpected architectural twist.
In the constant struggle with their environment, free-living cells have evolved a variety of mechanisms to deal with sudden variations in the physicochemical properties of their surroundings1. But few environmental challenges require more assertive responses than a hypo-osmotic insult.
- Valeria Vásquez is in the Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA.
- Eduardo Perozo is in the Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, USA.
Email: eperozo@uchicago.edu
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