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Nature 460, 584-585 (30 July 2009) | doi:10.1038/460584a; Published online 29 July 2009
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Developmental biology: Skeletal muscle comes of age
Terry Partridge1
Abstract
A regulatory protein thought to be crucial for maintaining the muscle stem-cell pool throughout life is shown to be dispensable in the adult. Muscle biologists are left wondering what fundamental things apply as time goes by.
When, as we grow up, we abandon our beloved teddy bear, we don't throw it away — we merely ignore it, a desertion that has parallels in skeletal-muscle development. Lepper et al.1 (page 627 of this issue) show that the Pax7 transcription factor, which is required for early juvenile muscle growth in mice, becomes inessential in the adult, although it is still expressed.
- Terry Partridge is at the Center for Genetic Medicine Research, Children's National Medical Center, Washington, DC 20010, USA.
Email: tpartridge@cnmcresearch.org
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