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Nature 460, 49-52 (2 July 2009) | doi:10.1038/nature08180; Received 20 February 2009; Accepted 29 May 2009
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Assistant / Associate Professor
- University of South Dakota - Biomedical Engineering
- 4800 N. Career Ave., Suite 118 Sioux Falls, SD 57107
Molecular Biologist (Positions Open in Bacteria, Fungal and Yeast Streams)
- Praj Matrix - Praj Industries Ltd
- Pune, Maharashtra Pune-411021 India
Elite and stochastic models for induced pluripotent stem cell generation
Abstract
Induced pluripotent stem cells offer unprecedented potential for disease research, drug screening, toxicology and regenerative medicine. However, the process of reprogramming is inefficient and often incomplete. Here I consider reasons for bottlenecks in induced pluripotent stem cell generation, and propose a model in which most or all cells have the potential to become pluripotent.
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