Access
To read this story in full you will need to login or make a payment (see right).
Progress
Nature 460, 49-52 (2 July 2009) | doi:10.1038/nature08180; Received 20 February 2009; Accepted 29 May 2009
Open Innovation Challenges
- More Challenges
- Powered by:
nature jobs
Assistant Manager-Pharma / CRO-Global Strategic Sourcing
- Varda Biotech
- Mumbai India
Postdoctoral Fellow in Immunology
- The Scripps Research Institute
- N Torrey Pines Rd, San Diego, CA, USA
Elite and stochastic models for induced pluripotent stem cell generation
Abstract
Induced pluripotent stem cells offer unprecedented potential for disease research, drug screening, toxicology and regenerative medicine. However, the process of reprogramming is inefficient and often incomplete. Here I consider reasons for bottlenecks in induced pluripotent stem cell generation, and propose a model in which most or all cells have the potential to become pluripotent.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Turning skin into embryonic stem cellsNature Medicine News and Views (01 Jul 2007)
Reprogramming by the numbersNature Biotechnology News and Views (01 Aug 2007)
See all 10 matches for News And ViewsRESEARCH
Suppression of induced pluripotent stem cell generation by the p53?p21 pathwayNature Letters to Editor (27 Aug 2009)
A drug-inducible transgenic system for direct reprogramming of multiple somatic cell typesNature Biotechnology Research (01 Aug 2008)
See all 42 matches for Research