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Nature 459, 931-939 (18 June 2009) | doi:10.1038/nature08157; Received 12 May 2009; Accepted 26 May 2009; Published online 14 June 2009

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Emergence and pandemic potential of swine-origin H1N1 influenza virus

Gabriele Neumann1, Takeshi Noda2 & Yoshihiro Kawaoka1,2,3,4

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Influenza viruses cause annual epidemics and occasional pandemics that have claimed the lives of millions. The emergence of new strains will continue to pose challenges to public health and the scientific communities. A prime example is the recent emergence of swine-origin H1N1 viruses that have transmitted to and spread among humans, resulting in outbreaks internationally. Efforts to control these outbreaks and real-time monitoring of the evolution of this virus should provide us with invaluable information to direct infectious disease control programmes and to improve understanding of the factors that determine viral pathogenicity and/or transmissibility.

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