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Nature 459, 654-655 (4 June 2009) | doi:10.1038/459654a; Published online 3 June 2009

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Developmental biology: The early heart remodelled

Fu-Sen Liang1 & Gerald R. Crabtree1

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What factors direct the formation of heart muscle in the developing embryo? Unexpectedly, a chromatin-remodelling protein complex turns out to be a crucial determinant of cardiac-cell fate.

The chances are that many of us will develop heart disease at some point in our lives. So understanding how heart muscle, heart valves and other heart structures regenerate is particularly important.

  1. Fu-Sen Liang and Gerald R. Crabtree are in the Departments of Pathology and Developmental Biology, Stanford University Medical School, Stanford, California 94305, USA.
    Email: crabtree@stanford.edu

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