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Biophysical dissection of membrane proteins

Nature volume 459, pages 344–346 (2009)Cite this article

Abstract

The first atomic-resolution structure of a membrane protein was solved in 1985. Twenty-four years and more than 180 unique structures later, what have we have learned? An examination of the atomic details of several diverse membrane proteins reveals some remarkable biophysical features and suggests that we can expect to achieve much more in the decades to come.

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Figure 1: Progress in determining membrane protein structures.

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Acknowledgements

This work was supported in part by grants from the National Institute of General Medical Science and the National Institute of Neurological Disorders and Stroke.

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  1. Department of Physiology and Biophysics, and Center for Biomembrane Systems, University of California, Irvine, 92697, California, USA

    Stephen H. White

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  1. Stephen H. White
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White, S. Biophysical dissection of membrane proteins. Nature 459, 344–346 (2009). https://doi.org/10.1038/nature08142

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