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Nature 459, 340-342 (21 May 2009) | doi:10.1038/459340a; Published online 20 May 2009

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Obesity: Causes and control of excess body fat

Jeffrey M. Friedman1

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Obesity is a major health problem in developed countries and a growing one in the developing world. It increases the risk of diabetes, heart disease, fatty liver and some forms of cancer. A better understanding of the biological basis of obesity should aid its prevention and treatment.

How is obesity diagnosed?Obesity is defined as excessive adiposity (body fat).

  1. Jeffrey M. Friedman is at the Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10065, USA.
    Email: friedj@rockefeller.edu

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