Table of contents
Volume 457 Number 7233 pp1057-1174
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Editorials
The way ahead for polar science p1057
The fourth International Polar Year is coming to an end. But the Arctic and Antarctic must remain top scientific priorities.
doi:10.1038/4571057a
See also: Editor's summary
Europe's GM quandary p1057
A political impasse over transgenic crops has left the European Commission with no good options.
doi:10.1038/4571057b
It's good to blog p1058
More researchers should engage with the blogosphere, including authors of papers in press.
doi:10.1038/4571058a
Research Highlights
Cell biology: Prion hijackers p1060
doi:10.1038/4571060a
Plant sciences: Rust resistant p1060
doi:10.1038/4571060b
Molecular biology: Adaptation p1060
doi:10.1038/4571060c
Animal behaviour: The carriers' code p1060
doi:10.1038/4571060d
Physics: Atomic quantum dots p1060
doi:10.1038/4571060e
Oceanography: Sky view p1060
doi:10.1038/4571060f
Nanotechnology: Etch a circuit sketch p1061
doi:10.1038/4571061a
Materials science: Better coats p1061
doi:10.1038/4571061b
Palaeontology: Flower power p1061
doi:10.1038/4571061c
Neuroscience: Mouse mapping p1061
doi:10.1038/4571061d
News
Antarctica's impossible peaks come into view p1062
Major polar project yields panorama of hidden mountains.
Alexandra Witze
doi:10.1038/4571062a
Harbour threat for coelacanths p1063
Tanzanian plan could damage rare fish's habitat.
Quirin Schiermeier
doi:10.1038/4571063a
Drug patent plan gets mixed reviews p1064
GlaxoSmithKline's bid to tackle neglected diseases receives a muted response from the rest of the industry.
Declan Butler
doi:10.1038/4571064a
Seabed images create waves p1065
Google Ocean incorporates copyrighted material.
Rex Dalton
doi:10.1038/4571065a
Hong Kong evolution curriculum row p1067
Intelligent design 'debate' sparks controversy.
David Cyranoski
doi:10.1038/4571067a
Satellite to monitor carbon sinks sinks p1067
Orbiting Carbon Observatory crashes into sea.Geoff Brumfiel
doi:10.1038/4571067b
Stem-cell inaction prompts concern p1068
Legal complexities may underlie the delay in fulfilling election pledge.
Meredith Wadman
doi:10.1038/4571068a
Energy agency scrambles to spend stimulus money p1068
Nobel laureate struggles to prioritize projects.
Jeff Tollefson
doi:10.1038/4571068b
Four arrests in Californian animal-rights activism p1070
doi:10.1038/4571070a
Commercial biofuels plant planned for Florida p1070
doi:10.1038/4571070b
Iran's uranium stockpile reaches weapons potential p1070
doi:10.1038/4571070c
Europa next outer-planet mission p1070
doi:10.1038/4571070d
deCode gets marketing go-ahead in California p1071
doi:10.1038/4571071a
Forensic science badly lacking in the United States p1071
doi:10.1038/4571071b
News Features
International Polar Year: In from the Cold p1072
As scientists celebrate the end of the International Polar Year, they see causes for concern on the frozen horizon, reports Quirin Schiermeier.
doi:10.1038/4571072a
International Polar Year: Notes from the poles p1074
The International Polar Year (IPY) has covered two full annual cycles at both poles. Consisting of 170 projects, it has involved more than 60 countries and cost about US$1.2 billion.
doi:10.1038/4571074a
International Polar Year: The social pole? p1077
As change in the Arctic accelerates, scientists and indigenous peoples have pressing reasons to work together, reports Richard Monastersky.
doi:10.1038/4571077a
Correspondence
Human dignity must be basis for debate on primate research p1079
Tim Fieblinger
doi:10.1038/4571079a
Rare BSE mutation raises concerns over risks to public health p1079
Malcolm A. Ferguson-Smith & Jürgen A. Richt
doi:10.1038/4571079b
Scientific links with Cuba flourished despite US embargo p1079
Arnold L. Demain
doi:10.1038/4571079c
Idea of a love drug was no mystery to Shakespeare p1079
Joan G. Ehrenfeld
doi:10.1038/4571079d
Commentary
Man, machine and in between p1080
Brain-implantable devices have a promising future. Key safety issues must be resolved, but the ethics of this new technology present few totally new challenges, says Jens Clausen.
doi:10.1038/4571080a
Essay
Microbial awakenings p1083
A theory of how microbes 'wake up' from dormancy could help to solve scientific mysteries and improve disease control, says Slava S. Epstein.
Slava S. Epstein
doi:10.1038/4571083a
Books and Arts
In Retrospect: the physics of sand dunes p1084
Ralph Bagnold's wartime posting to map the dunes of North Africa was like a desert epic — and it inspired his classic text on how wind-blown grains self-organize into regular patterns, explains Philip Ball.
Philip Ball
doi:10.1038/4571084a
Inside the map-maker's mind p1085
Jon Christensen reviews The Natures of Maps: Cartographic Constructions of the Natural World by Denis Wood & John Fels.
doi:10.1038/4571085a
Who's watching you? p1086
John Gilbey reviews The Privacy Advocates: Resisting the Spread of Surveillance by Colin J. Bennett and Privacy: A Manifesto by Wolfgang Sofsky & Steven Rendall.
doi:10.1038/4571086a
Movies for a scientific mind p1087
Jascha Hoffman reviews the Sundance Film Festival.
Jascha Hoffman
doi:10.1038/4571087a
Q&A: Getting under Darwin's skin p1087
Charles Darwin's relationship with his wife Emma is the subject of the film Creation. Actor Paul Bettany describes portraying Darwin's turmoil over his daughter's death and religious conflict with his wife.
Adam Rutherford
doi:10.1038/4571087b
News and Views
Global change: Carbon in idle croplands p1089
The collapse of the Soviet Union had diverse consequences, not least the abandonment of crop cultivation in many areas. One result has been the vast accumulation of soil organic carbon in the areas affected.
Geoffrey M. Henebry
doi:10.1038/4571089a
Alzheimer's disease: A prion protein connection p1090
More than 20 million people worldwide have Alzheimer's disease, yet its causes remain mostly uncertain. Fresh findings provide molecular clues, linking this disease to another neurodegenerative disorder.
Moustapha Cisse & Lennart Mucke
doi:10.1038/4571090a
See also: Editor's summary
Asteroids: When planets migrate p1091
A study of the main asteroid belt, which lies between Mars and Jupiter, reveals an excess depletion of asteroids that was triggered by the migration of giant planets in the early history of the Solar System.
Kevin J. Walsh
doi:10.1038/4571091a
See also: Editor's summary
50 & 100 years ago p1092
doi:10.1038/4571092a
Climate change: Southern see-saw seen p1093
The bipolar see-saw hypothesis provides an explanation for why temperature shifts in the two hemispheres were out of phase at certain times. The hypothesis has now passed a test of one of its predictions.
Jeffrey P. Severinghaus
doi:10.1038/4571093a
See also: Editor's summary
Palaeontology: Birth of the jawed vertebrates p1094
The discovery of embryos in certain fossil fishes not only shows that internal fertilization and live birth evolved early in vertebrate history, but also raises questions about the origin of jawed vertebrates.
Per E. Ahlberg
doi:10.1038/4571094a
See also: Editor's summary
Obesity: Fat chance p1095
Sadaf Shadan
doi:10.1038/4571095a
Brief Communications Arising
Is REST required for ESC pluripotency? pE4
Helle F. Jørgensen, Zhou-Feng Chen, Matthias Merkenschlager & Amanda G. Fisher
doi:10.1038/nature07783
First paragraph | Full Text | PDF (293K)
Is REST a regulator of pluripotency? pE5
Noel J. Buckley, Rory Johnson, Yuh-Man Sun & Lawrence W. Stanton
doi:10.1038/nature07784
First paragraph | Full Text | PDF (293K)
Singh et al. reply pE7
Sanjay K. Singh, Mohamedi N. Kagalwala, Jan Parker-Thornburg, Henry Adams & Sadhan Majumder
doi:10.1038/nature07785
First paragraph | Full Text | PDF (293K)
Corrigendum
Ecologically implausible carbon response? pE8
Wim de Vries, Svein Solberg, Matthias Dobbertin, Hubert Sterba, Daniel Laubhann, Gert Jan Reinds, Gert-Jan Nabuurs, Per Gundersen & Mark A. Sutton
doi:10.1038/nature07826
Articles
Interhemispheric Atlantic seesaw response during the last deglaciation p1097
Stephen Barker, Paula Diz, Maryline J. Vautravers, Jennifer Pike, Gregor Knorr, Ian R. Hall & Wallace S. Broecker
doi:10.1038/nature07770
Abstract | Full Text | PDF (626K) | Supplementary information
See also: Editor's summary | News and Views by Severinghaus
A mechanosensitive transcriptional mechanism that controls angiogenesis p1103
Akiko Mammoto, Kip M. Connor, Tadanori Mammoto, Chong Wing Yung, Dongeun Huh, Christopher M. Aderman, Gustavo Mostoslavsky, Lois E. H. Smith & Donald E. Ingber
doi:10.1038/nature07765
Abstract | Full Text | PDF (966K) | Supplementary information
See also: Editor's summary
Letters
A record of planet migration in the main asteroid belt p1109
David A. Minton & Renu Malhotra
doi:10.1038/nature07778
First paragraph | Full Text | PDF (189K) | Supplementary information
See also: Editor's summary | News and Views by Walsh
Large positive magnetoresistive effect in silicon induced by the space-charge effect p1112
Michael P. Delmo, Shinpei Yamamoto, Shinya Kasai, Teruo Ono & Kensuke Kobayashi
doi:10.1038/nature07711
First paragraph | Full Text | PDF (558K) | Supplementary information
See also: Editor's summary
Friction laws at the nanoscale p1116
Yifei Mo, Kevin T. Turner & Izabela Szlufarska
doi:10.1038/nature07748
First paragraph | Full Text | PDF (638K) | Supplementary information
See also: Editor's summary
Giant aeolian dune size determined by the average depth of the atmospheric boundary layer p1120
Bruno Andreotti, Antoine Fourrière, Fouzia Ould-Kaddour, Brad Murray & Philippe Claudin
doi:10.1038/nature07787
First paragraph | Full Text | PDF (841K) | Supplementary information
See also: Editor's summary
Devonian arthrodire embryos and the origin of internal fertilization in vertebrates p1124
John A. Long, Kate Trinajstic & Zerina Johanson
doi:10.1038/nature07732
First paragraph | Full Text | PDF (1,020K) | Supplementary information
See also: Editor's summary | News and Views by Ahlberg
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-
oligomers p1128
Juha Laurén, David A. Gimbel, Haakon B. Nygaard, John W. Gilbert & Stephen M. Strittmatter
doi:10.1038/nature07761
First paragraph | Full Text | PDF (910K) | Supplementary information
See also: Editor's summary | News and Views by Cisse & Mucke
Intracortical circuits of pyramidal neurons reflect their long-range axonal targets p1133
Solange P. Brown & Shaul Hestrin
doi:10.1038/nature07658
First paragraph | Full Text | PDF (1,150K) | Supplementary information
See also: Editor's summary
Dendritic encoding of sensory stimuli controlled by deep cortical interneurons p1137
Masanori Murayama, Enrique Pérez-Garci, Thomas Nevian, Tobias Bock, Walter Senn & Matthew E. Larkum
doi:10.1038/nature07663
First paragraph | Full Text | PDF (1,510K) | Supplementary information
See also: Editor's summary
The subcellular organization of neocortical excitatory connections p1142
Leopoldo Petreanu, Tianyi Mao, Scott M. Sternson & Karel Svoboda
doi:10.1038/nature07709
First paragraph | Full Text | PDF (971K) | Supplementary information
See also: Editor's summary
Deficiency of a -arrestin-2 signal complex contributes to insulin resistance p1146
Bing Luan, Jian Zhao, Haiya Wu, Baoyu Duan, Guangwen Shu, Xiaoying Wang, Dangsheng Li, Weiping Jia, Jiuhong Kang & Gang Pei
doi:10.1038/nature07617
First paragraph | Full Text | PDF (490K) | Supplementary information
See also: Editor's summary
Organ regeneration does not require a functional stem cell niche in plants p1150
Giovanni Sena, Xiaoning Wang, Hsiao-Yun Liu, Hugo Hofhuis & Kenneth D. Birnbaum
doi:10.1038/nature07597
First paragraph | Full Text | PDF (1,125K) | Supplementary information
See also: Editor's summary
Ca2+/calmodulin regulates salicylic-acid-mediated plant immunity p1154
Liqun Du, Gul S. Ali, Kayla A. Simons, Jingguo Hou, Tianbao Yang, A. S. N. Reddy & B. W. Poovaiah
doi:10.1038/nature07612
First paragraph | Full Text | PDF (920K) | Supplementary information
See also: Editor's summary
Direct observation of the nanoscale dynamics of membrane lipids in a living cell p1159
Christian Eggeling, Christian Ringemann, Rebecca Medda, Günter Schwarzmann, Konrad Sandhoff, Svetlana Polyakova, Vladimir N. Belov, Birka Hein, Claas von Middendorff, Andreas Schönle & Stefan W. Hell
doi:10.1038/nature07596
First paragraph | Full Text | PDF (685K) | Supplementary information
See also: Editor's summary
Pyrrolysyl-tRNA synthetase–tRNAPyl structure reveals the molecular basis of orthogonality p1163
Kayo Nozawa, Patrick O'Donoghue, Sarath Gundllapalli, Yuhei Araiso, Ryuichiro Ishitani, Takuya Umehara, Dieter Söll & Osamu Nureki
doi:10.1038/nature07611
First paragraph | Full Text | PDF (940K) | Supplementary information
See also: Editor's summary
Corrigendum
A role for VEGF as a negative regulator of pericyte function and vessel maturation p1168
Joshua I. Greenberg, David J. Shields, Samuel G. Barillas, Lisette M. Acevedo, Eric Murphy, Jianhua Huang, Lea Scheppke, Christian Stockmann, Randall S. Johnson, Niren Angle & David A. Cheresh
doi:10.1038/nature07824
Erratum
Adaptive immune features of natural killer cells p1168
Joseph C. Sun, Joshua N. Beilke & Lewis L. Lanier
doi:10.1038/nature07833
Corrigendum
Regulation of ERBB2 by oestrogen receptor–PAX2 determines response to tamoxifen p1168
Antoni Hurtado, Kelly A. Holmes, Timothy R. Geistlinger, Iain R. Hutcheson, Robert I. Nicholson, Myles Brown, Jie Jiang, William J. Howat, Simak Ali & Jason S. Carroll
doi:10.1038/nature07835
Naturejobs
ProspectsExpert Counsel p1169
Career-conscious scientists should heed advice given to governments and institutions about coping with the downturn.
Gene Russo
doi:10.1038/nj7233-1169a
Region
Weathering the slump p1170
Despite an economy that is sputtering, Ireland has recommitted to investing in science. Quirin Schiermeier examines the latest research investments on the Emerald Isle.
Quirin Schiermeier
doi:10.1038/nj7233-1170a
Career View
John Polich, director, Global NeuroLab Operations, NeuroFocus, Berkeley, California p1172
Neuroscientist brings expertise in brain-wave activity to new role as director of Global NeuroLab.
Virginia Gewin
doi:10.1038/nj7233-1172a
EMBL offers lab training in Europe p1172
New training centre in Germany seen as counterpart to US facility.
Paul Smaglik
doi:10.1038/nj7233-1172b
Nice day for a white wedding? p1172
A shotgun wedding and a big move
Joanne Isaac
doi:10.1038/nj7233-1172c
Futures
Lost in sun and silence p1174
The golden age of communication.
Vincenzo Palermo
doi:10.1038/4571174a
