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Nature 457, 970-971 (19 February 2009) | doi:10.1038/457970a; Published online 18 February 2009
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Neuroscience: Good and bad cell death
Donald W. Nicholson1
Abstract
Neurodegeneration often has disease connotations. However, it is also a developmental process for fine sculpting of the nervous system. One signalling cascade might mediate the process in both circumstances.
A major driver of neurodegeneration in Alzheimer's disease is thought to be plaques of amyloid-
peptides. These 40–42-amino-acid fragments form when the transmembrane amyloid- precursor protein (APP) is degraded by the enzymes - and 
-secretase.
- Donald W. Nicholson is at Merck Research Laboratories, Rahway, New Jersey 07065, USA.
Email: donald_nicholson@merck.com
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APP binds DR6 to trigger axon pruning and neuron death via distinct caspasesNature Article (19 Feb 2009)
