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Nature 457, 668-669 (5 February 2009) | doi:10.1038/457668a; Published online 4 February 2009
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Post-doctoral Fellowship In Functional Neuroimaging
- National Institute of Mental Health
- Bethesda, Maryland
Graduate Student Award in Statistical Lipidomics
- University of Ottawa
- Ottawa, ON K1H8M5
Cell biology: How to combat stress
Christopher V. Nicchitta1
Abstract
Life is full of stress, and all life forms — from bacteria to humans — have evolved ways of sensing and responding to it. The latest findings shed light on how cells deal with stress.
In cells, protein homeostasis — a delicate balance between maintaining protein conformations, refolding misfolded proteins and degrading damaged proteins — is normally maintained by regulatory networks that control protein synthesis and degradation. Moreover, molecular chaperones are key players in protein homeostasis, helping proteins to fold and preventing aggregation of misfolded proteins, which could have substantial, disease-related consequences1, 2.
- Christopher V. Nicchitta is in the Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Email: c.nicchitta@cellbio.duke.edu
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