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Nature 457, 269-270 (15 January 2009) | doi:10.1038/457269a; Published online 14 January 2009

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Stem cells: Tailor-made diseased neurons

Michael Sendtner1

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How can we investigate a disease affecting neurons, which cannot be isolated from patients for analysis? As the study of one neurological disorder shows, a first step might be to make patient-specific neurons.

Spinal muscular atrophy (SMA) is among the most common inherited neurological disorders that can cause death in childhood. Although the most severe form of the condition is known to be due to mutations in both copies of the SMN1 gene, an understanding of how SMA develops has been slow.

  1. Michael Sendtner is at the Institute of Clinical Neurobiology, University of Würzburg, Zinklesweg 10, 97078 Würzburg, Germany.
    Email: sendtner_m@klinik.uni-wuerzburg.de

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