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From the following article:

Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

Sunhwa Kim, Hiroyuki Takahashi, Wan-Wan Lin, Pascal Descargues, Sergei Grivennikov, Youngjun Kim, Jun-Li Luo & Michael Karin

Nature 457, 102-106(1 January 2009)

doi:10.1038/nature07623

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Figure 1

Metastatic carcinomas secrete factors that induce macrophage production of TNF-alpha, needed for lung metastasis.

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Figure 2

LLC-secreted factor activates TLR2 to induce lung inflammation.

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Figure 3

TLR2 is required for metastatic growth.

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Figure 4

Versican is a TLR2 agonist and metastasis-enhancing factor.

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