Access

News and Views

Nature 456, 887-888 (18 December 2008) | doi:10.1038/456887a; Published online 17 December 2008

Open Innovation Challenges

  • Single-cell Analysis Platform

    • Deadline: Dec 02 2009
    • Reward: $5,000 USD

    This Challenge is looking for novel approaches to analyzing changes at a single-cell level. This is...

  • Optimizing Sub-cellular Localization Tags

    • Deadline: Nov 29 2009
    • Reward: $20,000 USD

    The Seeker is looking for methods to optimize sub-cellular localization tags for protein expression....

naturejobs

More science jobs
Post a job for free

Neuroscience: Greasy proteins of the neuron

Maurine E. Linder1

Top

An analysis of neuronal proteins reveals that many are regulated through covalent attachment of the lipid palmitate. This reversible modification seems to affect the form and function of synaptic junctions.

Phosphates, lipids, sugars and even small polypeptides covalently attach to proteins, changing a protein's activity, localization or stability. Such modifications can be either reversible or permanent.

  1. Maurine E. Linder is in the Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
    Email: mlinder@wustl.edu

MORE ARTICLES LIKE THIS

These links to content published by NPG are automatically generated.

RESEARCH

Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation

Nature Article (18 Dec 2008)

A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis

Nature Cell Biology Article (01 Jun 2009)

How curved membranes recruit amphipathic helices and protein anchoring motifs

Nature Chemical Biology Article (01 Nov 2009)