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Nature 456, 887-888 (18 December 2008) | doi:10.1038/456887a; Published online 17 December 2008
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Assistant / Associate Professor
- University of South Dakota - Biomedical Engineering
- 4800 N. Career Ave., Suite 118 Sioux Falls, SD 57107
Academic Neuropathologist
- University Hospitals Case Medical Center
- Cleveland, Ohio, USA
Neuroscience: Greasy proteins of the neuron
Maurine E. Linder1
Abstract
An analysis of neuronal proteins reveals that many are regulated through covalent attachment of the lipid palmitate. This reversible modification seems to affect the form and function of synaptic junctions.
Phosphates, lipids, sugars and even small polypeptides covalently attach to proteins, changing a protein's activity, localization or stability. Such modifications can be either reversible or permanent.
- Maurine E. Linder is in the Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
Email: mlinder@wustl.edu
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