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Review
Nature 455, 613-619 (2 October 2008) | doi:10.1038/nature07352
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Team Leader for Analytical Development
- Novo Nordisk
- Bagsværd, Denmark
Senior Scientist, Bioinformatics and Protein Design
- Novo Nordisk Foundation Center for Protein Research, University of Copenhagen
- Copenhagen 2200 Denmark
Challenges in the development of an HIV-1 vaccine
Dan H. Barouch1
Abstract
The development of a safe and effective human immunodeficiency virus (HIV)-1 vaccine is a critically important global health priority. Despite recent advances in our understanding of HIV-1 pathogenesis and immunology, however, major scientific obstacles remain. Prototype HIV-1 vaccine candidates aimed at eliciting humoral and cellular immune responses have so far failed to protect against HIV-1 infection or to reduce viral loads after infection in clinical efficacy studies. A renewed and coordinated commitment to basic discovery research, preclinical studies and clinical trials will therefore be required to overcome the hurdles currently facing the field. Here I review key challenges and future prospects in the quest to develop a prophylactic HIV-1 vaccine.
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