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Nature 455, 607-608 (2 October 2008) | doi:10.1038/455607a; Published online 1 October 2008
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Neuroscience: Fragile dopamine
David Weinshenker1 & Stephen T. Warren1
Abstract
Dopamine dysfunction, which is implicated in Parkinson's disease and drug addiction, seems an unlikely culprit in fragile X syndrome. A surprising set of findings means a rethink is required.
Fragile X syndrome is the commonest inherited form of mental retardation, with the patients often also having autism and attention-deficit hyperactivity disorder1. It is usually caused by the absence of the protein FMRP, which is encoded by FMR1, a gene on the X chromosome.
- David Weinshenker and Stephen T. Warren are in the Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Email: dweinsh@emory.edu
Email: swarren@emory.edu
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