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News and Views
Nature 455, 473-474 (25 September 2008) | doi:10.1038/455473a; Published online 24 September 2008
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Professor of Experimental Virology (W3)
- University Hospital Jena, Institute of Virology and Antivirale Therapy
- Jena, Germany
John Innes Centre Project Leader in Plant or Microbial Sciences
- University of East Anglia
- Norwich, NR4 7TJ, UK
Structural biology: A moving story of receptors
Thue W. Schwartz1 & Wayne L. Hubbell2
Abstract
Animals sense light and chemical signals through proteins called G-protein-coupled receptors. The crystal structure of one such receptor in complex with a G-protein fragment shows how these receptors are activated.
The cell membranes of animals — everything from mammals to molluscs, insects and flatworms — contain proteins called G-protein-coupled receptors. Also known as 7TM receptors because of their seven transmembrane helices, they are involved in sensing light and a multitude of chemical signals: not only hormones and other transmitter molecules, but also odours, pheromones and flavours1.
- Thue W. Schwartz is at the Laboratory for Molecular Pharmacology, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark.
Email: tws@sund.ku.dk - Wayne L. Hubbell is at the Jules Stein Eye Institute and the Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, USA.
Email: hubbellw@jsei.ucla.edu
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