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Nature 455, 304-308 (18 September 2008) | doi:10.1038/nature07367; Published online 17 September 2008

The advent and development of organocatalysis

David W. C. MacMillan1

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The use of small organic molecules as catalysts has been known for more than a century. But only in the past decade has organocatalysis become a thriving area of general concepts and widely applicable asymmetric reactions. Here I present my opinion on why the field of organocatalysis has blossomed so dramatically over the past decade.

  1. David W. C. MacMillan is at the Merck Center for Catalysis at Princeton University, 116 Frick Laboratory, Princeton University, Princeton, New Jersey 08540, USA.

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