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News and Views
Nature 455, 178-179 (11 September 2008) | doi:10.1038/455178a; Published online 10 September 2008
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Schizophrenia: Incriminating genomic evidence
James R. Lupski1
Abstract
The genetic factors that contribute to schizophrenia can vary, making it difficult to pinpoint which DNA changes are the main culprits. Large genome-wide studies provide the most reliable clues yet.
Schizophrenia is a chronic, debilitating illness with both neurological and psychiatric features, and it affects an estimated 1% of the world's population. Intense research into this disorder clearly points to the involvement of a significant genetic component, but genetic studies of schizophrenia have generally been disappointing as the data obtained often cannot be reproduced1.
- James R. Lupski is in the Departments of Molecular and Human Genetics, and of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas 77030, USA.
Email: jlupski@bcm.tmc.edu
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