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Nature 454, 709-710 (7 August 2008) | doi:10.1038/454709a; Published online 6 August 2008
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Postdoctoral Fellow in Immunology
- The Scripps Research Institute
- N Torrey Pines Rd, San Diego, CA, USA
Head of Analytical R&D
- Syngene International Limited
- Bangalore 560 099 India
Cell biology: A molecular age barrier
Matt Kaeberlein1
Abstract
A mother's instinct is to protect her children at any cost. In the budding yeast Saccharomyces cerevisiae this 'maternal instinct' comes at a high price — accelerated ageing and premature death.
Cells of budding yeast divide asymmetrically, with the larger mother cell easily distinguishable from her daughter. This asymmetry, which is not just structural but also affects the distribution of cellular components, ensures a type of ageing in yeast — replicative ageing — that is defined by the number of daughter cells a mother produces1.
- Matt Kaeberlein is in the Department of Pathology, University of Washington, Seattle, Washington 98195, USA.
Email: kaeber@u.washington.edu
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