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Nature 454, 709-710 (7 August 2008) | doi:10.1038/454709a; Published online 6 August 2008
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Laboratory Manager / Principal Research Assistant
- Wellcome Trust Sanger Institute
- Hinxton, Cambridge, CB10 1SA, UK
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- Life Technologies
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Cell biology: A molecular age barrier
Matt Kaeberlein1
Abstract
A mother's instinct is to protect her children at any cost. In the budding yeast Saccharomyces cerevisiae this 'maternal instinct' comes at a high price — accelerated ageing and premature death.
Cells of budding yeast divide asymmetrically, with the larger mother cell easily distinguishable from her daughter. This asymmetry, which is not just structural but also affects the distribution of cellular components, ensures a type of ageing in yeast — replicative ageing — that is defined by the number of daughter cells a mother produces1.
- Matt Kaeberlein is in the Department of Pathology, University of Washington, Seattle, Washington 98195, USA.
Email: kaeber@u.washington.edu
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