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Nature 454, 702-703 (7 August 2008) | doi:10.1038/454702a; Published online 6 August 2008
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Postdoctoral Associate in Enzyme Biochemistry
- Cornell University
- Ithaca, New York
Senior Faculty Positions
- Torrey Pines Institute for Molecular Studies
- Port St. Lucie, FL
Tuberculosis: Shrewd survival strategy
Steven A. Porcelli1
Abstract
Mycobacterium tuberculosis modulates its virulence to cause persistent but often subclinical infection. This strategy is regulated in part by a feedback loop that controls the secretion of a small subset of bacterial proteins.
The bacterium that causes tuberculosis is one of the most successful pathogens. Its spread among humans has been so efficient that as much as one-third of the world's population is now believed to be infected1.
- Steven A. Porcelli is in the Departments of Microbiology and Immunology, and of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA.
Email: porcelli@aecom.yu.edu
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