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Nature 454, 288-289 (17 July 2008) | doi:10.1038/454288a; Published online 16 July 2008
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Systems biology: On the cell cycle and its switches
Silvia D. M. Santos1 & James E. Ferrell1
Abstract
For the cell-division cycle to progress, hundreds of genes and proteins must be coordinately regulated. Systems-level studies of this cycle show that positive-feedback loops help to keep events in sync.
The cell cycle is a complex but orderly sequence of events that culminates in the production of two cells from one. In eukaryotes, the cycle is divided into four phases: cell growth in G1 phase, DNA replication in S phase, more growth in G2 phase, and cell division in mitosis or M phase.
- Silvia D. M. Santos and James E. Ferrell are in the Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305–5174, USA.
Email: james.ferrell@stanford.edu
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